Human dermal fibroblast proliferation controlled by surface roughness of two-component nanostructured latex polymer coatings

Rosqvist, Emil; Niemelä, Erik; Venu, Arun P.; Kummala, Ruut; Ihalainen, Petri; Toivakka, Martti; Eriksson, John E.; Peltonen, Jouko

doi:10.1016/j.colsurfb.2018.10.064

Cited by 21 publications

(18 citation statements)

References 32 publications

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“…In a recent study employing human dermal fibroblasts, Rosqvist et al found that surfaces with roughness of approximately Sa 11 nm favored the proliferation yield of cells [57]. The study also concluded that surface effects on cell proliferation stems from nanoscale roughness [57]. The surface analysis through AFM in our study supports the findings of previous studies.…”

Section: Discussionsupporting

confidence: 88%

“…The nanoscale roughness of the coated zirconia grains is higher than non-coated zirconia grains. In a recent study employing human dermal fibroblasts, Rosqvist et al found that surfaces with roughness of approximately Sa 11 nm favored the proliferation yield of cells [57]. The study also concluded that surface effects on cell proliferation stems from nanoscale roughness [57].…”

Section: Discussionmentioning

confidence: 99%

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TiO₂Coating and UV Photofunctionalization Enhance Blood Coagulation on Zirconia Surfaces

Shahramian

Abdulmajeed

Kangasniemi

et al. 2019

BioMed Research International

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This in vitro study was designed to evaluate the effect of sol-gel derived TiO2coating on blood coagulation, blood protein adsorption, and platelet response on zirconia surfaces. Square-shaped zirconia (n=96) (10x10x2 mm) was cut, ground, sintered, and finally cleansed ultrasonically in each of acetone and ethanol for 5 minutes. Three experimental groups (n=32) were fabricated: (a) zirconia coated with sol-gel derived TiO2, (b) zirconia coated with sol-gel derived TiO2and treated with ultraviolet (UV) irradiation for 1 hour, and (c) non-coated zirconia as control. The coatings were prepared from tetraisopropyl orthotitanate solution by dip-coating. The thrombogenicity of the specimens was evaluated using a whole blood kinetic clotting time method where the extent of blood clotting was evaluated at 10, 20, 30, 40, 50, and 60 minutes (n=4/time point, total n=24/group). Scanning electron microscope images were taken to observe platelet morphologies after 1-hour incubation with platelet-rich plasma (PRP) (n=5/group). Surface characteristics were visualized using atomic force microscopy (n=1/group). Adsorption of plasma proteins and fibronectin on each surface was studied by gel electrophoresis (n=2/group). Significant differences were observed in blood coagulation between the test groups at 20-, 30-, 40-, and 50-minute time points (p<0.005). UV treated TiO2coated specimens showed fastest blood coagulation followed by TiO2coated and non-coated specimens. Furthermore, platelets appeared at a higher activation state on coated specimens. Gel electrophoresis revealed no difference in protein adsorption among the experimental groups. In summary, TiO2coatings promoted blood coagulation, and it was further enhanced by UV treatment, which has the potential to hasten the wound healing process in vivo.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

TiO₂Coating and UV Photofunctionalization Enhance Blood Coagulation on Zirconia Surfaces

Shahramian

Abdulmajeed

Kangasniemi

et al. 2019

BioMed Research International

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“…Polymer latexes synthesized through emulsion polymerization (EP) is a special topic, which might be old in the time survey, but is highlighted by the recent enthusiasm developing “green” organic coatings industries for architecture, 1 original equipment manufacture (OEM) 2 and special fields in requirement of additional functions 3,4 . In response to the advanced demands, great efforts have been done exploring the influence of the subtle synthetic parameters on the microstructure evolution which shows complexity, but dramatically importance to the behavior of the latex as well as its film under dynamically mechanical forces 5 .…”

Section: Introductionmentioning

confidence: 99%

The crosslinking directing dynamic behavior of polymer latex under the investigation toward waterborne damping coatings

Guo

et al. 2020

J of Applied Polymer Sci

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Latex polymers with precisely designed dynamic mechanical behavior are the key for waterborne damping coatings, which are widely desired in noise and vibration reduction with additional environmental benefits. In this work, we synthesized series of polymer latexes with various crosslinking agents (CA) and network distributions through the control on emulsion polymerization processes. We have revealed that the variation on crosslinking can significantly direct the latex behavior under dynamic conditions as well as its films. The variables involve the CA composition, the functionality, the crosslinking manner, the hydrophilic‐hydrophobic feature as well as the feeding method. Although all the latex films showed the damping peaks locating in the range from −10 to 70°C, their damping behaviors were quite different. Suggested by the empirical parameters of LA and TA, the product from sequential monomer feeding method tended to give good extensional damping performance. Especially when the crosslinking of diacetone acrylamide (DAAM)/adipic dihydrazide was applied, there was a linear increase on LA with the increasing dosage of DAAM from 0 to 10 mmol in the final monomer addition batch. Meanwhile, good constrained layer damping is expected on the products from the power monomer feeding method with the maximum CA dosage shown below 7.5 mmol. The best TA was achieved when the CA of divinylbenzene was used in the dosage of 5 mmol. These results would be valuable to be referenced in the engineering on organic damping materials toward modern industrial and vehicles applications.

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“…In addition, the stiffnesses of the two components in a blend coating of commercial latices have been previously determined as 0.13 GPa for ABS and 1.61 GPa for PS. 30 Correspondingly, the board was coated with 70 : 30 blends of L-01 and L-02 ( Fig. 1C), as well as L-05 and L-02 ( Fig.…”

Section: Characterization Of the Paper Substratementioning

confidence: 99%

“…For instance a moderately smooth surface in terms of the parameters S q , S dr and normalized roughness has been found to be preferential for high HDF proliferation. 29,30 Also, topologies with a Brownian fractal dimension 2.5 have been speculated to activate the FAK signaling pathway, and through that mechanism increase cell proliferation. 29,33 For applications or studies that are used with specific cell lines this tuning can be done more freely, as different cell types can react very differently to different surface properties.…”

Section: Characterization Of the Paper Substratementioning

confidence: 99%

A low-cost paper-based platform for fast and reliable screening of cellular interactions with materials

et al. 2020

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Human dermal fibroblast proliferation controlled by surface roughness of two-component nanostructured latex polymer coatings

Cited by 21 publications

References 32 publications

TiO₂Coating and UV Photofunctionalization Enhance Blood Coagulation on Zirconia Surfaces

TiO₂Coating and UV Photofunctionalization Enhance Blood Coagulation on Zirconia Surfaces

The crosslinking directing dynamic behavior of polymer latex under the investigation toward waterborne damping coatings

A low-cost paper-based platform for fast and reliable screening of cellular interactions with materials

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Human dermal fibroblast proliferation controlled by surface roughness of two-component nanostructured latex polymer coatings

Cited by 21 publications

References 32 publications

TiO2Coating and UV Photofunctionalization Enhance Blood Coagulation on Zirconia Surfaces

TiO2Coating and UV Photofunctionalization Enhance Blood Coagulation on Zirconia Surfaces

The crosslinking directing dynamic behavior of polymer latex under the investigation toward waterborne damping coatings

A low-cost paper-based platform for fast and reliable screening of cellular interactions with materials

Contact Info

Product

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TiO₂Coating and UV Photofunctionalization Enhance Blood Coagulation on Zirconia Surfaces

TiO₂Coating and UV Photofunctionalization Enhance Blood Coagulation on Zirconia Surfaces