Human Disease Due to Mycobacterium smegmatis

Wallace, Richard J.; Nash, Donald R.; Tsukamura, M; Blacklock, Zeta M.; Silcox, Vella A.

doi:10.1093/infdis/158.1.52

Cited by 142 publications

(136 citation statements)

References 27 publications

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“…In 1986 Vonmoos et al [138] reported the first case of pleuropulmonary disease caused by M. smegmatis. Wallace and co-workers [139] identified 22 additional human isolates of M. smegmatis from Australia and the southern United States: 19 were from skin or soft-tissue infections, and none were from urine or the male genital tract.…”

Section: Ulcerans This Organism Was First Isolated In 1948mentioning

confidence: 99%

Epidemiology and Clinical Significance of Nontuberculous Mycobacteria in Patients Negative for Human Immunodeficiency Virus in Switzerland

Debrunner

Brändli

Graevenitz

1992

Clinical Infectious Diseases

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Section: Ulcerans This Organism Was First Isolated In 1948mentioning

confidence: 99%

Epidemiology and Clinical Significance of Nontuberculous Mycobacteria in Patients Negative for Human Immunodeficiency Virus in Switzerland

Debrunner

Brändli

Graevenitz

1992

Clinical Infectious Diseases

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“…In contrast, there were 33 nonrespiratory isolates, approximately two-thirds of which were known to be clinically significant. The most common types of clinical disease associated with the MCLO were posttraumatic wound infections and catheter-related sepsis, which are clinical diseases that are relatively commonly caused by members of other taxonomic groups of rapidly growing mycobacteria (3,(22)(23)(24)27). Extensive growth and biochemical analyses of the 87 MCLO isolates revealed that they were fairly homogeneous and had characteristics similar to those described 10 years earlier (2, 17), except that they exhibited variable nitrate reduction reactions (45%) ( Table 1).…”

mentioning

confidence: 99%

Phylogeny of the Mycobacterium chelonae-Like Organism Based on Partial Sequencing of the 16S rRNA Gene and Proposal of Mycobacterium mucogenicum sp. nov.

Springer

Böttger

Kirschner

et al. 1995

International Journal of Systematic Bacteriology

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121

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The Mycobacterium chelonae-like organism (MCLO) is a recently described member of the Mycobacterium fortuitum complex which causes posttraumatic skin infections and catheter sepsis. This taxon is a distinct group biochemically and has a unique mycolic acid profile as determined by high-performance liquid chromatography. Its phylogenetic relationships to other mycobacteria, however, have not been studied previously. We sequenced 1,062 bp of the 16s rRNA genes from three MCLO strains obtained from the American Type Culture Collectien and compared our results with the sequences of previously described taxa of rapidly growing and slowly growing mycobacteria. Two biochemically typical strains (ATCC 49650T [T = type strain] and ATCC 49651) had identical sequences, while the sequence of a biochemically atypical strain (ATCC 49649) differed by 4 bp from the sequence of the two typical strains. The Hamming distances between these MCLO strains and related rapidly growing mycobacteria are comparable to the Hamming distances among taxa of rapidly growing mycobacteria established as species by DNA-DNA hybridization. We propose the name Mycobacterium mucogenicum sp. nov. for this new taxon because of the highly mucoid nature of most isolates on solid media.Two closely related outbreaks of peritonitis associated with automated peritoneal dialysis machines occurred in 1976 and 1978 in the northwestern United States (2). The causative organism, which was recovered from peritoneal fluid, the automated dialysis machines, and tap water used to supply the machines, was a previously undescribed, nonpigmented, rapidly growing mycobacterium. This organism was identified as a member of the Mycobacten'um fortuitum complex on the basis of its partial acid-fast staining (10 to 25%), a positive 3-day arylsulfatase reaction, and growth on MacConkey agar without crystal violet at 28°C (17). Because many other laboratory characteristics of the organism were similar to those of Mycobacterium chelonae (formerly M. chelonae subsp. chelonae) (17,25), including failure to grow on medium containing 5% sodium chloride, inability to reduce nitrate, borderline or negative reaction in the iron uptake test, and utilization of citrate as a sole carbon source (Table l), the organism was tentatively designated the M. chelonae-like organism (MCLO) by Silcox et al. (17).In the subsequent 10 years, this organism was only rarely identified as a human pathogen; usually it was identified as a cause of nosocomial infections associated with water, such as the water in processed hemodialysis equipment (3). In 1993 Wallace et al. published a review of 87 clinical isolates of MCLO encountered sporadically in a mycobacterial laboratory in the southwestern United States (26). The majority of these isolates were respiratory isolates and had no clinical significance except in immunocompromised hosts. In contrast, there were 33 nonrespiratory isolates, approximately two-thirds of which were known to be clinically significant. The most common types of clinical disease ass...

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“…Only 9 cases of infection caused by M. wolinskyi have been reported (1)(2)(3), and these included 3 cases of bone infection and 1 case of infection of a hip prosthesis. All patients had a history of surgery after traumatic injury and all specimens were isolated from the surgical wound.…”

Section: Bacteremia Caused By Mycobacterium Wolinskyimentioning

confidence: 99%