Human Endophthalmitis Caused By Pseudorabies Virus Infection, China, 2017

Ai, Jingwen; Weng, Shanshan; Cheng, Qi; Cui, Peng; Li, Yongjun; Wu, Honglong; Zhu, Yimin; Xu, Bin; Zhang, Wenhong

doi:10.3201/eid2406.171612

Cited by 184 publications

(151 citation statements)

References 9 publications

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“…Pseudorabies virus has a wide host range including human and cattle. It has been reported that a pig farmworker was infected by PRV after exposure to sewage (Ai et al, ). There are also several reports in different countries mentioned human was infected by PRV (Wong et al, ).…”

Section: Resultsmentioning

confidence: 99%

Natural infection of a variant pseudorabies virus leads to bovine death in China

Cheng

Kong

Liu

et al. 2019

Transbound Emerg Dis

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Pseudorabies virus (PRV) infects numerous species of domestic and wild animals leading to severe diseases especially in swine and cattle. Since 2011, the variant PRVs were identified in pigs, which were genetically different from classic strains. Although variant PRV infection is widely observed in pigs, there is still no report of variant PRV infection in cattle. Here, we reported a natural infection of variant PRV leading to acute bovine death in Eastern China. Our study suggests that the new variant PRV strains could be a potential threat to cattle industry and possibly to the public health of human.

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Section: Resultsmentioning

confidence: 99%

Natural infection of a variant pseudorabies virus leads to bovine death in China

Cheng

Kong

Liu

et al. 2019

Transbound Emerg Dis

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“…Additionally, PCR, known as the gold standard for diagnosis, relies on prior knowledge or assumptions of the type of pathogen causing infection [20]. Furthermore, pathogen-specific PCR assays could not provide enough evidence for the etiological diagnosis of viral CNS infections, since dozens of virus families can cause nervous system infections [22] and a few animal viruses with the capability of crossing the species barriers, such as pseudorabies virus, could infect human being [23,24]. However, NGS technique can allow for the detection of etiological evidence in clinical samples without any prior knowledge of pathogen specificity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study

Xing

Zhang

et al. 2018

Eur Neurol

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Background: There are sparse and limited studies on small sample size reporting the application of next-generation sequencing (NGS) in the detection of central nervous system (CNS) viral infections. We assessed the diagnostic performance of NGS of cerebrospinal fluid (CSF) for predicting viral infections of the CNS caused by the neurotropic herpes viruses in a pilot population. Materials and Methods: We prospectively collected CSF samples from 24 patients with CNS viral infection from April 2017 to October 2018. Of the 24 patients, 19 patients were infected with herpes simplex virus 1 (HSV-1), 1 patient with HSV-2, and 4 patients with varicella-zoster virus (VZV). All CSF samples were screened for viral DNA using NGS technologies to detect viral CNS infections. Results: Of the 24 patients with confirmed viral CNS infection caused by the neurotropic herpes viruses, 10 (10/24, 41.67%) patients exhibited positive NGS results. With the help of NGS, HSV-1 DNA was detected in the CSF of 6 patients (6/19; 31.58%). HSV-2 DNA was detected in 1 patient (1/1; 100%) and VZV DNA was detected in 3 patients (3/4; 75%). The positive rate of virus detected by NGS decreased with time. The positive rates of NGS of CSF in the first, second, and third weeks were 54.5% (6/11), 44.4% (4/9), and 0% (0/4), respectively. Conclusions: NGS method is a promising pathogen detection tool for identifying viral CNS infections. It should be recommended to sequence viral DNA of CSF in the early stage of CNS viral infections.

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“…Pseudorabies virus (PRV), a member of Alphaherpesvirinae subfamily within the family Herpesviridae , causes Aujeszky's disease mainly in pigs. Recently, Ai et al reported human endophthalmitis caused by PRV infection upon exposure to sewage on a swine farm of Jiangxi Province of China (Ai et al, ), which raised a public concern of PRV as zoonosis. Here, we report another case of severe encephalitis caused by PRV infection in Hebei Province of China.…”

Section: Dynamic Cerebrospinal Fluid (Csf) Analysis Over the Course Omentioning

confidence: 99%

“…Several suspicious cases of PRV infection in Europe developed weakness, sore throat and mild neurological symptoms (Mravak, Bienzle, Feldmeier, Hampl, & Habermehl, ). The recent case in China reported that the patient infected by PRV developed fever, headache and visual impairment (Ai et al, ). In this case, direct contact of contaminated blood from needle stick injury results in disturbed consciousness, and seizures followed by both severe encephalitis and irreversible visual loss.…”

Section: Dynamic Cerebrospinal Fluid (Csf) Analysis Over the Course Omentioning

confidence: 99%

Dynamic cerebrospinal fluid analyses of severe pseudorabies encephalitis

Zheng

Liu

Yuan

et al. 2019

Transbound Emerg Dis

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Human Endophthalmitis Caused By Pseudorabies Virus Infection, China, 2017

Cited by 184 publications

References 9 publications

Natural infection of a variant pseudorabies virus leads to bovine death in China

Natural infection of a variant pseudorabies virus leads to bovine death in China

Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study

Dynamic cerebrospinal fluid analyses of severe pseudorabies encephalitis

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