“…the accurate diagnosis of women with a pelvic mass, and detects more cases on time at stage I/II than CA125 alone [41,76,77]. Complex analysis of these markers culminated in the ROMA evaluation and opened a new era in medical oncology [78]. However, some demographic parameters should be considered when HE4 is utilized in the detection of EOC, thus we hope that our proposed decision algorithm will be helpful for clinicians and laboratory professionals in those cases when HE4 values may be misleading to differentiate malignant and benign conditions.…”