2012
DOI: 10.1515/cclm-2012-0683
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Human epididymis protein 4: the start of a post-ROMAn era?

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Cited by 3 publications
(2 citation statements)
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“…the accurate diagnosis of women with a pelvic mass, and detects more cases on time at stage I/II than CA125 alone [41,76,77]. Complex analysis of these markers culminated in the ROMA evaluation and opened a new era in medical oncology [78]. However, some demographic parameters should be considered when HE4 is utilized in the detection of EOC, thus we hope that our proposed decision algorithm will be helpful for clinicians and laboratory professionals in those cases when HE4 values may be misleading to differentiate malignant and benign conditions.…”
Section: Resultsmentioning
confidence: 99%
“…the accurate diagnosis of women with a pelvic mass, and detects more cases on time at stage I/II than CA125 alone [41,76,77]. Complex analysis of these markers culminated in the ROMA evaluation and opened a new era in medical oncology [78]. However, some demographic parameters should be considered when HE4 is utilized in the detection of EOC, thus we hope that our proposed decision algorithm will be helpful for clinicians and laboratory professionals in those cases when HE4 values may be misleading to differentiate malignant and benign conditions.…”
Section: Resultsmentioning
confidence: 99%
“…In clinical practice, the concentrations of circulating biomarkers are often measured serially to follow the course of the disease. Although the clinical significance of serial determination of CA125 is controversial [ 13 ], and a prospective trial has been interpreted as demonstrating the absence of benefit of serial CA125 measurement to detect early recurrence [ 17 ], in another study the detection of CA125 rise increased the chance of optimal secondary surgical cytoreduction that was associated with an improvement of survival [ 18 ].…”
mentioning
confidence: 99%