The birth time of Homo sapiens is still controversial between 2 million and 100 thousand years ago. A new paradigm can resolve the deadlock: The glacial maximum ~140 ka wiped out Pre-Sapiens almost completely but a small population macroevolutionary progressed into Sapiens in the Levant ~140 ka, and REAL early moderns, REAL early Neanderthals, and REAL early Denisovans originated from this new population. In other words, the common ancestral population was NOT in Africa before 500 ka. The evidence presented here for the parallelism between paleoclimatic coolings and anatomical retrogressions, and vice versa, suggests that retro-progressive evolution was DNA-driven. It means that DNA has retrogressive and progressive forces and also a nonstop dominance struggle between the two. Seemingly, extreme coolings and warmings were a triggering factor for rearrangement of DNA. At those times, the DNA sometimes produced both anatomical and behavioral progression (such as the birth of Sapiens and a synchronous shift from Tabun D-type Mousterian to Tabun C-type), sometimes anatomical retrogression but behavioral progression (for example, despite anatomical retrogression, the reappearance of Neanderthal burials in MIS 4), and also sometimes both anatomical and behavioral retrogression (such as the births of Floresiensis and Luzonensis). This DNA-driven process can also explain the extinctions of Neanderthals, Denisovans, and the hobbits: an increasing progressive dominance (a decreasing retrogressive dominance) in their DNA. If this was the case, the enigma that why Sapiens is the only living species of the genus Homo is enlightened too.