Human Evolution: the Study of Indian Mitochondrial DNA

Barnabás, S.; Apte, R. V.; Suresh, C.G.

doi:10.1007/s001140050241

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent genetic studies (Quintana‐Murci et al 1999; Barnabas et al 2000; Kivisild et al 2003) support the existence and continuation of a proto‐Asian and proto‐European population in India. In an earlier study based on polymorphic sites, we found mtDNA separation between Dravidian and Indo‐European language speakers (Barnabas et al 1996a). In another study, higher frequencies of the mtDNA haplogroup ‘M’ were found in northeastern (68%) and midwestern tribal (61%) samples, whereas the frequency was only slightly higher in non‐tribal Dravidian language speakers (55%) compared to the Indo‐European language speakers (52%) (Barnabas et al 2000).…”

Section: Introductionmentioning

confidence: 59%

“…The loss of the AvaII site at 4332, seen in KA88, is observed in West‐Eurasians (Torroni et al 1994a) whereas TA108 and ML103 (though a signature mutation for ‘U’ could not be tested) appear to be related to ‘U1’ and these are found in Dravidian language speakers. These two distinct branches hint at the separation of the two major Indian language groups (Barnabas et al 1996 a,b) as observed in Y‐chromosomal (Quintana‐Murci et al 2001; Mukherjee et al 2001) as well as autosomal studies (Sitalaxmi et al 2003), representing the more recent farming and pastoral migrations.…”

Section: Resultsmentioning

confidence: 99%

“…This study included 117 Indians with data for 27 Indians from an earlier study (Quintana‐Murci et al 1999). The mtDNAs were extracted from placental tissues, blood (Barnabas et al 1996 a, b) and oral cells. The Indian samples were collected over a period of time with informed consent of the subjects and are identified by their language groups.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

High‐Resolution mtDNA Studies of the Indian Population: Implications for Palaeolithic Settlement of the Indian Subcontinent

Barnabás

Shouche

Suresh

2005

Annals of Human Genetics

Self Cite

View full text Add to dashboard Cite

SummaryThe population of the Indian subcontinent represents a very complex social and cultural structure. Occupying a geographically central position for the early modern human migrations, indications are that the founder group that migrated out of East Africa also reached India. In the present study we used the twin strategy of mapping the whole mitochondrial DNA (mtDNA) using the standard 14 restriction enzymes, and sequencing the non-transcribed HVSI region, to derive maximum maternal lineages from a sample of non-tribal Indians. The essential features of the reduced median network of the two datasets were the same. Both showed two demographic expansions of two major haplogroups, 'M' and 'N'. The reduced median network was drawn with inputs from other studies on the Indian population, and correlated with data from other ethnic populations. The coalescence time of expansions and genetic diversity were estimated.A reduced median network was also drawn combining data from studies on Africans, Southeast Asians and WestEurasians, tracing the migration of 'M' from East Africa to India. A time estimate of the migration of major mtDNA haplogroups from Africa was attempted. The comparison of a set of Indian maternal lineages belonging to different geographical regions of the country, with other populations revealed the in-situ differentiation and antiquity of the Indian population. Our analysis places the 'southern route' migration as the source of haplogroup 'M'. Multiple migrations might have brought the other major haplogroups, 'N' and 'R', found in our sample to India. Archaeological evidence of modern humans in the subcontinent supports this mtDNA study.

show abstract

Section: Introductionmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

High‐Resolution mtDNA Studies of the Indian Population: Implications for Palaeolithic Settlement of the Indian Subcontinent

Barnabás

Shouche

Suresh

2005

Annals of Human Genetics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, the possible cause of higher frequencies of CCR5-∆32 among Muslims and North Indians may be because of admixture as the Eurasians migrated through Europe [38]. Our results also suggest a sporadic presence of CCR5-∆32 mutations in some of the South Indian populations, which may be accredited to the presence of Eurasian Y chromosome haplotype groups in some of these populations [39,40]. Thus, the genetic admixture of Eurasians and Caucasians could possibly be one of the reasons for such distribution patterns and frequencies in India.…”

Section: Prevalence Of Ccr5-∆32 In Indiamentioning

confidence: 58%

The Latitude Wise Prevalence of the CCR5-Δ32-HIV Resistance Allele in India

Bhatnagar

Singh

Mishra

et al. 2009

Balkan Journal of Medical Genetics

View full text Add to dashboard Cite

The chemokine receptor CCR5 plays a crucial role during CD4-mediated entry of HIV-1 in macrophages and a 32 bp deletion in the CCR5 gene (CCR5-∆32) confers protection against HIV infection and AIDS progression. To evaluate the contribution of this host genetic factor in aggravating India's HIV/AIDS problem, we exclusively examined the frequency of CCR5-∆32 in 43 different ethnic endogamous Indian populations comprising 1,882 individuals and its latitude-wise distribution in India. This is the first report of prevalence and latitude-wise distribution of CCR5-∆32 in such large scale in India, which indicates that most of the Indian populations lack the CCR5-∆32 mutation. This mutation was exhibited in only 13 out of the 43 ethnic populations of India studied with allelic frequency 0.62 -5%. Southward decreasing cline was observed for frequencies of CCR5-∆32 (0.79% to 5.0% in North vs. 0.62% to 1.4% South). These results are in accordance with HIV/AIDS prevalence in India, and suggest that absence of CCR5-∆32 mutation may be one of the important factors for HIV/AIDS incidence in India.

show abstract

“…from each language group). However, in a preliminary study (Barnabas et al 1996) of the data we noticed that the population belonging to the central state of Maharashtra showed distinguishably low diversity in comparison to populations from the north and the south. Since we have studied a statistically significant number of Central Indians, we decided to sample the data into three populations : North Indians, South Indians and Central Indians (from Maharashtra).…”

Section: Populationsmentioning

confidence: 75%

Ancestry and interrelationships of the Indians and their relationship with other world populations: A study based on mitochondrial DNA polymorphisms*

Barnabás¹,

Apte²,

Suresh³

1996

Annals of Human Genetics

Self Cite

View full text Add to dashboard Cite

Mitochondrial DNA variation was studied in 100 Indians using the same set of six restriction enzymes used in the study of other world ethnic groups in order to compare and discern possible relationships of the Indian populations. Twenty nine mtDNA types were found including the ones from an earlier study (Semino et al. 1991) and unweighted pair-group method (UPGMA) and maximum parsimony trees were constructed using the mtDNA types. The nucleotide diversity values were calculated using the maximum likelihood method. From a study of the shared mitochondrial DNA types and the parsimony tree (Fig. 2) we came to the conclusion that the Indian population is closer to Caucasians and has an admixture with Asians. The North Indian population appears to have a recent admixture of the Caucasian mtDNA types which is absent in the south.

show abstract

Human Evolution: the Study of Indian Mitochondrial DNA

Cited by 3 publications

References 0 publications

High‐Resolution mtDNA Studies of the Indian Population: Implications for Palaeolithic Settlement of the Indian Subcontinent

High‐Resolution mtDNA Studies of the Indian Population: Implications for Palaeolithic Settlement of the Indian Subcontinent

The Latitude Wise Prevalence of the CCR5-Δ32-HIV Resistance Allele in India

Ancestry and interrelationships of the Indians and their relationship with other world populations: A study based on mitochondrial DNA polymorphisms*

Contact Info

Product

Resources

About