Human Exposure to Novel<i>Bartonella</i>Species from Contact with Fruit Bats

Bai, Ying; Osinubi, Modupe; Osikowicz, Lynn M.; McKee, Clifton; Vora, Neil M.; Rizzo, Maria Rosales; Recuenco, Sergio; Davis, Lora; Niezgoda, Mike; Ehimiyein, Ajoke Modupeoluwa; Kia, G.S.N.; Oyemakinde, Akin; Adeniyi, Olufunmilayo Sanni; Gbadegesin, Yemi H.; Saliman, Olugbon A.; Ogunniyi, Abiodun; Ogunkoya, Albert; Kosoy, Michael

doi:10.3201/eid2412.

Cited by 6 publications

(8 citation statements)

References 45 publications

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“…The detection of the zoonotic pathogen “ Candidatus Bartonella mayotimonensis” (Lin et al, ) in bats in the Northern Hemisphere (Lilley et al, ; Stuckey, Boulouis, et al, ; Veikkolainen, Vesterinen, Lilley, & Pulliainen, ) associated to the serological evidence of human exposure to Bartonella rousetii , a new Bartonella species detected in fruit bats and bat flies from Nigeria (Bai et al, ), raises the need for further investigation of the diversity of Bartonella species in bats. Indeed, Bartonella spp.…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity ofBartonellaspp. in vampire bats from Brazil

André

Gutiérrez

Ikeda

et al. 2019

Transbound Emerg Dis

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Recently, an increasing number of Bartonella species have been emerged to cause human diseases. Among animal reservoirs for Bartonella spp., bats stand out due to their high mobility, wide distribution, social behaviour and long‐life span. Although studies on the role of vampire bats in the epidemiology of rabies have been extensively investigated in Latin America, information on the circulation and genetic diversity of Bartonella species in these bat species is scarce. In the present work, 208 vampire bats, namely Desmodus rotundus (the common vampire bat; n = 167), Diphylla ecaudata (the hairy‐legged vampire bat; n = 32) and Diaemus youngii (the white‐winged vampire bat; n = 9) from 15 different states in Brazil were sampled. DNA was extracted from liver tissue samples and submitted to real‐time PCR (qPCR) and conventional PCR (cPCR) assays for Bartonella spp. targeting five genetic loci, followed by phylogenetic and genotype network analyses. Fifty‐one out of 208 liver samples (24.51%) were positive for Bartonella DNA in the ITS real‐time PCR assay [40 (78.43%) of them were from D. rotundus from 11 states, and 11 (21.57%) samples from D. ecaudata from three states. Eleven genotypes were found for each gltA and rpoB genes. Several ITS sequences detected in the present study clustered within the lineage that includes B. bacilliformis and B. ancachensis. The Bayesian phylogenetic inference based on the gltA gene positioned the obtained sequences in six different clades, closely related to Bartonella genotypes previously detected in D. rotundus and associated ectoparasites sampled in Latin America. On the other hand, the Bartonella rpoB genotypes clustered together with the ruminant species, B. schoenbuchensis and B. chomelii. The present study describes for the first time the molecular detection of Bartonella spp. in D. ecaudata bats. It also indicates that Bartonella spp. of vampire bats are genetically diverse and geographically widespread in Brazil.

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Section: Introductionmentioning

confidence: 99%

Genetic diversity ofBartonellaspp. in vampire bats from Brazil

André

Gutiérrez

Ikeda

et al. 2019

Transbound Emerg Dis

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“…Candidatus Bartonella rousetti was first reported as a previously unclassified Bartonella strain detected from Rousettus aegyptiacus in Kenya in 2010 [ 15 ]. Thereafter, the same strain was detected during a survey on Bartonella species in bats and bat flies in a cave in southwestern Nigeria, where people entered and captured bats during a traditional bat festival [ 17 ]. The study also assessed human exposure to the bacterium using an indirect immunofluorescence assay and detected immunoglobulin G (IgG) against Ca .…”

Section: Discussionmentioning

confidence: 88%

“…from Eucampsipoda sp. of South Africa (KR997986), respectively [ 17 , 23 ]. Sequence type 3 showed 95.5% (315/330 bp) similarity to the Bartonella symbiont of Eu.…”

Section: Resultsmentioning

confidence: 99%

“…The study also assessed human exposure to the bacterium using an indirect immunofluorescence assay and detected immunoglobulin G (IgG) against Ca . B. rousetti in the sera of several individuals from the surrounding communities without any cross-reaction to other Bartonella genotypes [ 17 ]. In the present study, Ca .…”

Section: Discussionmentioning

confidence: 99%

“…A Bartonella genotype detected in bats in Georgia (Caucasus) showed high similarity with Bartonella sequences found in the sera of forest workers in Poland [ 14 ]. Furthermore, a recent serological study reported the detection of antibodies against Candidatus Bartonella rousetti, which was previously detected in bats in Kenya and Nigeria [ 15 , 16 ], among the people who entered the caves to capture bats during a traditional bat festival in southwestern Nigeria [ 17 ]. Collectively, these findings strengthen the importance of public health-related studies on bat-associated bartonellae.…”

Section: Introductionmentioning

confidence: 99%

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Isolation of Candidatus Bartonella rousetti and Other Bat-associated Bartonellae from Bats and Their Flies in Zambia

et al. 2020

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Bat-associated bartonellae, including Bartonella mayotimonensis and Candidatus Bartonella rousetti, were recently identified as emerging and potential zoonotic agents, respectively. However, there is no report of bat-associated bartonellae in Zambia. Thus, we aimed to isolate and characterize Bartonella spp. from bats and bat flies captured in Zambia by culturing and PCR. Overall, Bartonella spp. were isolated from six out of 36 bats (16.7%), while Bartonella DNA was detected in nine out of 19 bat flies (47.3%). Subsequent characterization using a sequence of five different genes revealed that three isolates obtained from Egyptian fruit bats (Rousettus aegyptiacus) were Ca. B. rousetti. The isolates obtained from insectivorous bats (Macronycteris vittatus) were divided into two previously unclassified bat-associated bartonellae. A phylogenetic analysis of the six genotypes of Bartonella gltA sequences from nine pathogen-positive bat flies revealed that three genotypes belonged to the same clades as bat-associated bartonellae, including Ca. B. rousetti. The other three genotypes represented arthropod-associated bartonellae, which have previously been isolated only from ectoparasites. We demonstrated that Ca. B. rousetti is maintained between bats (R. aegyptiacus) and bat flies in Zambia. Continuous surveillance of Bartonella spp. in bats and serological surveys in humans in Africa are warranted to evaluate the public health importance of bat-associated bartonellae.

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Seasonal challenges of tropical bats (Rousettus aegyptiacus) in temperate zones

Weinberg

Mazar

Goutnik³

et al. 2022

Preprint

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Egyptian fruit bats (Rousettus aegyptiacus) manage to survive and flourish in a large geographic range despite the variability of natural and anthropogenic conditions in this range. To examine the challenges faced by free-ranging R. aegyptiacus living at the northern edge of their distribution, we performed a retrospective analysis of ~1500 clinical cases reported by a bat rescue NGO over 25 months, from all over Israel. All cases of injured or stranded bats were evaluated and categorized according to date, place, sex, age, and etiology of the morbidity. The analysis of the data showed an increase in all types of morbidity during the wintertime, with more than twice the number of cases in comparison with the summertime, over two consecutive years. Moreover, we found that the number of abandoned pups peaks during spring till autumn when adult morbidity is minimal. We characterize two prominent types of previously undescribed morbidity in R. aegyptiacus, one in the form of bacterial illness, and the other associated with feet deformation which affects bats in addition to major anthropogenic-related threats related to synanthropic predators. We analyze the reasons driving winter morbidity and conclude that winter weather and specifically low temperature best explains this morbidity. We hypothesize that R. aegyptiacus, a fruit-bat of tropical origin is facing major seasonal difficulties near the northern edge of its distribution, probably limiting its further spread northward.

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Human Exposure to NovelBartonellaSpecies from Contact with Fruit Bats

Cited by 6 publications

References 45 publications

Genetic diversity ofBartonellaspp. in vampire bats from Brazil

Genetic diversity ofBartonellaspp. in vampire bats from Brazil

Isolation of Candidatus Bartonella rousetti and Other Bat-associated Bartonellae from Bats and Their Flies in Zambia

Seasonal challenges of tropical bats (Rousettus aegyptiacus) in temperate zones

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