Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures

Abstract

Background: The possibility of using stem cells for regenerative medicine has opened a new field of investigation. The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive procedures is of great interest. It has been shown that mesenchymal stem cells (MSCs) obtained from umbilical cords, dental pulp and adipose tissue, which are all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages. The aim of this study was to isolate, expand, characterize and assess the differentiation potential of MSCs from human fallopian tubes (hFTs).

Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications

“…Adult quiescent stem cells have been described extensively over the past decade. Recently Jazedje et al isolated cells from primary human fallopian tubes and induced multi-lineage differentiation in these cells to become adipogenic, chondrogenic, myogenic and osteogenic when cultured in unique differentiation media, 25 suggesting that the fallopian tube harbors cells with stem-like characteristics and can give rise to tumors of different histotypes upon interaction with the stem cell niche (microenvironment).…”

Chlamydia trachomatisInhibits Inducible NO Synthase in Human Mesenchymal Stem Cells by Stimulating Polyamine Synthesis

“…Normal pieces from human fallopian tube tissue samples were used to isolate and culture MSCs as described previously (26).…”

“…The cells were derived from fallopian tubes-a rich source of MSCs (26). Although the basal layer of the endometrium, which contains MSCs, is normally shielded from Chlamydia by the functional layer, this is sloughed off during menses, leaving the regenerative basal layer exposed (32,33).…”

Mesenchymal stem cells for the treatment of tendon disorders

“…Another source of MSCs is adipose tissue, which produces MSCs similar to bone marrow MSCs, but easier to produce with broader therapeutic capacity [29]. MSCs have also been found in umbilical cord blood [30], dental tissues [31], synovial fluid [32], palatine tonsil [33], the parathyroid gland [34] and the fallopian tubes [35]. MSC transplantation is a promising strategy because of its relative lack of ethical problems and the absence of any development of teratomas, as observed after embryonic stem cell or iPS cell transplantations; in addition, MSCs are easily harvested using a minimally invasive procedure.…”