Human growth hormone level decreased in women aged &lt;60 years but increased in men aged &gt;50 years

Wang, Ximei; Wang, Shuyi; Wu, Huan; Jiang, Mingfei; Xue, Hui; Zhu, Yangqi; Wang, Chenxu; Zha, Xiaojuan

doi:10.1097/md.0000000000018440

Cited by 3 publications

(3 citation statements)

References 38 publications

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Section: Hormones Involved In Development Of Nafldmentioning

confidence: 97%

“…Wang et al determined a U-shaped relationship between GHs and age in the different genders and after sex stratification. The thresholds of age were 60 years in women and 50 years in men, with a strong regression showing that the GH level decreased in women aged <60 years (OR = 1.472, p < 0.001) and increased in men aged >50 years (OR = 0.711, p < 0.001) [38]. The role of GHs is driven by sexual dimorphism, as it is produced by the pituitary gland, which is characterized by a pulsatile release in males; on the contrary, in infertile women, the release is continuous, and its function is to regulate the transcription of certain liver genes and protein production, including those related to lipid metabolism.…”

Section: Hormones Involved In Development Of Nafldmentioning

confidence: 99%

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Premenopausal Syndrome and NAFLD: A New Approach Based on Gender Medicine

et al. 2022

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Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition that affects 25% of the world’s population. There is a clear difference in both geographical distribution and sex in childbearing age. These differences are reduced when women become older and senescence begins. The factors that affect the likelihood of developing NAFLD in a premenopausal woman are an imbalance of sex hormones (especially in estradiol and androgen), microbiome dysregulation, insulin resistance, early menarche, the length of time that the woman breastfeeds for and polycystic ovarian syndrome (PCOS). The aim of this review is to identify various physical ailments that may not appear to be serious to young women but that then affect the onset of NAFLD in perimenopause and can degenerate into NASH. These conditions should also be considered in future clinical management, as well as in research opportunities, in order to customize the monitoring and treatment of NAFLD, considering gender medicine for those women who had early metabolic symptoms that were not considered to be significant at the time.

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Section: Hormones Involved In Development Of Nafldmentioning

confidence: 97%

Section: Hormones Involved In Development Of Nafldmentioning

confidence: 99%

Premenopausal Syndrome and NAFLD: A New Approach Based on Gender Medicine

et al. 2022

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“…Exercise is promoted as an appropriate and effective approach to increase GH-mediated energy expenditure to prevent the development of obesity (Rejeki et al, 2023;Strasser, 2013). Exercise can also improve metabolic health by increasing physical performance, lipid and glucose metabolism (lipolysis and insulin sensitivity), and weight maintenance (Wang et al, 2020;Dávila Grisalez, Mazuera Quiceno, Carreño Herrera, & Henao Corrales, 2021), so it can improve metabolic health (Dourida et al, 2019). Exercise is also known to prevent deficiency of GH secretion in overweight and obese individuals (Al-Samerria & Radovick, 2021).…”

Section: Introductionmentioning

confidence: 99%

Aerobic Exercise Increases Release of Growth Hormone in the Blood Circulation in Obese Women

Pranoto,

Rejeki,

Miftahussurur

et al. 2023

Retos

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Physical exercise is one of the modulators in increasing the release of growth hormone (GH) levels in blood circulation, but the effective exercise model for obese subjects is still being debated. Therefore, this study aims to prove the effect of aerobic exercise on increasing the release of GH levels in the blood circulation in obese women. A total of 20 obese adult women, aged 21.00 ± 1.08 years were selected to be subjects in the study and were given one aerobic exercise intervention by running on a treadmill at moderate-intensity (60-70% HRmax) for 40 minutes. The ELISA method was used to measure the release of GH levels in all samples (pre- and post-exercise). Statistical analysis in this study used an independent sample t-test with a significant level of 5%. The results showed that the release of GH levels in the blood circulation was found to be higher in post-exercise compared to pre-exercise after one session of aerobic exercise (484.92±128.29 vs 892.63±273.54 pg/mL; p=0.001) and has a large effect size with a Cohen's d value of 1.909. GH levels in the post-exercise blood circulation in the aerobic exercise group (Exr) were also found to be higher than the GH levels in the control group (Ctr) (892.63±273.54 vs 542.97±140.01 pg/mL; p=0.003) and has a large effect size with a Cohen's d value of 1.609. This study proves that one session of aerobic exercise with moderate intensity increases the release of circulating GH levels in obese women. Therefore, aerobic exercise with moderate intensity can be used as an alternative therapy option to increase the release of circulating GH levels in individuals with obesity. Keywords: aerobic exercise, growth hormone, metabolism, obesity.

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Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s

Sugiharto

Merawati

Pranoto

et al. 2022

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives Overweight status decreases the growth hormone (GH) secretion, thus, increasing the risk factors for medical complications. However, proper exercise is reported to enhance GH and affect the energy balance. Therefore, exercise is proclaimed to be an accurate and engaging therapy to increase GH in preventing overweight. This study aims to investigate the physiological response of exercise in mediating the increase of GH secretion in female adolescents. Methods 22 overweight women aged 19–20 years old, with maximal oxygen consumption of 27–35 mL/kg/min, were selected as sample size. They were divided into three groups, namely (CONT, n=7) Control, (MIEE, n=7) Moderate-intensity interval endurance exercise, and (MCEE, n=8) Moderate-intensity continuous endurance exercise. The exercise was carried out by running for 30–35 min using treadmills with an intensity of 60–70% HRmax. The blood sampling for GH examination was carried out four times before exercise, 10 min, 6 h, and 24 h after exercise. The enzyme-linked immunosorbent assay (ELISA) was used to measure the GH and IGF-1 levels. The data analysis was carried out using a one-way ANOVA test, with a significance level of 5%. Results The results of the one-Way ANOVA test suggested a significantly different average GH and IGF-1 before and after the exercise between the three groups (CON, MIEE, and MCEE) (p≤0.05). Conclusions MCEE increases the GH and IGF-1 levels more considerably than MIEE. Therefore, exercise is a mediator to increase GH and IGF-1 secretion in overweight individuals. Exercise could be a viable therapy for overweight people.

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Human growth hormone level decreased in women aged <60 years but increased in men aged >50 years

Cited by 3 publications

References 38 publications

Premenopausal Syndrome and NAFLD: A New Approach Based on Gender Medicine

Premenopausal Syndrome and NAFLD: A New Approach Based on Gender Medicine

Aerobic Exercise Increases Release of Growth Hormone in the Blood Circulation in Obese Women

Physiological response of endurance exercise as a growth hormone mediator in adolescent women’s

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