Human Health Hazards from Antimicrobial‐ResistantEscherichia coliof Animal Origin

Abstract

Because of the intensive use of antimicrobial agents in food animal production, meat is frequently contaminated with antimicrobial-resistant Escherichia coli. Humans can be colonized with E. coli of animal origin, and because of resistance to commonly used antimicrobial agents, these bacteria may cause infections for which limited therapeutic options are available. This may lead to treatment failure and can have serious consequences for the patient. Furthermore, E. coli of animal origin may act as a donor of antimicrobial resistance genes for other pathogenic E. coli. Thus, the intensive use of antimicrobial agents in food animals may add to the burden of antimicrobial resistance in humans. Bacteria from the animal reservoir that carry resistance to antimicrobial agents that are regarded as highly or critically important in human therapy (e.g., aminoglycosides, fluoroquinolones, and third- and fourth-generation cephalosporins) are of especially great concern.

Patterns of Efflux Pump Genes Among Tetracycline Resistance Uropathogenic Escherichia coli Isolates Obtained From Human Urinary Infections

“…Monitoring the distribution prevalence of tetracycline resistance genes, we found that the tetB gene had the highest frequency among the studied determinants. Escherichia coli is a facultative Gram-negative bacterium, which can cause many infections, like diarrhea, urinary tract infections, meningitis, peritonitis, and septicemia in humans (13). However, the most prevalent form of the extraintestinal infection caused by E. coli is urinary tract infection (14).…”

Ampicillin-sulbactam Effect in Respiratory Infections in Thoroughbred Horses: A Preliminar Study

“…The resistance was observed for Nilidixic Acid, Ciprofloxacin and Penicillin. The emergence of resistance to various antibiotics is of considerable medical and correlates, with their use and sometimes uncontrollably in the treatment of infectious diseases [1,[7][8][9]. In this situation raises new therapeutic molecules in the pharmaceutical industry with more power in less time and fewer adverse effects.…”

Antimicrobial Resistance Arising from Food-Animal Productions and Its Mitigation

“…First, the colonization of zoophilic resistant bacteria in human gut could compromise the therapeutic effect of treatment of human infections because most antibiotics either are used both in humans and animals or share the same resistance mechanism. Second, there is the risk of gene exchange between colonized exogenous resistant bacteria and bacteria indigenous to human intestines (Hammerum & Heuer, 2009;Luangtongkum et al, 2009;Walsh & Fanning, 2008). Although it remains to be determined if colonization of pathogens of animal origin in human gut results in transfer of their resistant gene to human intestinal microbiome, the potential warrants careful examination in future studies.…”