Human Herpes Virus Type 8 among Female-Sex Workers

Nzivo, Mirriam M.

doi:10.15406/jhvrv.2017.05.00176

Cited by 2 publications

(2 citation statements)

References 47 publications

(115 reference statements)

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“…Nonsexual transmission of HHV-8 may be the predominant route through which HHV-8 is transmitted in Kenya. A review from studies on HHV-8 among FSWs around the world observed that high risk behavior and STIs were not associated with HHV-8 infection by majority of studies evaluated; concluding FSWs did not play a major role in HHV-8 transmission hence heterosexual transmission [39]. We interpret our results as indicating that sexual transmission of HHV-8 occurs rarely in this population.…”

Section: Discussionmentioning

confidence: 55%

Prevalence and Risk Factors of Human Herpes Virus Type 8 (HHV-8), Human Immunodeficiency Virus-1 (HIV-1), and Syphilis among Female Sex Workers in Malindi, Kenya

Nzivo

Lwembe

Odari

et al. 2019

Interdisciplinary Perspectives on Infectious Diseases

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The prevalence of Human Herpes Virus type 8 (HHV-8), Human Immunodeficiency virus (HIV), and syphilis is high in Sub-Saharan Africa. Studies on HHV-8 in Kenya are few and data on its coinfection with HIV and syphilis scanty. This cross-sectional study among female sex workers (FSWs) in Malindi, Kenya, aimed to determine the prevalence of HHV-8, HIV, and syphilis mono/coinfections and identify associated risk factors. A total of 268 FSWs consented and were administered a structured questionnaire and screened for antibodies against HHV-8, HIV, and syphilis following the National Guidelines. FSWs positive for HHV-8 were 67/268 (25%), HIV 44/268 (16.4%), and 6/268 (2.24%) for syphilis. Eight out of 67 (12%) tested positive for HHV-8/HIV and 2/67 (3%) for HHV-8/syphilis coinfections. Married FSWs had higher odds of HHV-8 infection (OR 2.90, 95%, and P=0.043). Single marital status was inversely associated (OR 0.46, 95% CI 0.23-0.94, and P=0.034) with HIV infection. HIV was associated with increasing age (OR 14.79, P<0.001), inconsistent condom use (OR 2.69, P=0.004), increased duration as sex worker ≥6 (OR 3.0, P=0.002) and clients ≥4 (OR 4.0, P<0.001), intravenous drug use (OR 2.5, P=0.043), and early sex debut (P=0.049) unlike HHV-8 which was not associated with high risk sexual behavior. HHV-8/HIV coinfection was associated with increasing age (OR 11.21, P=0.027). Infection by HHV-8 was not significantly associated with HIV (OR 0.62; P=0.257) or syphilis (OR 1.52; P=0.636). There was a high likelihood of infection with HHV-8 compared to HIV (OR 8.6, P=0.014) and syphilis (OR 14.6, P<0.001). The lack of association of HHV-8 with high risk sexual behavior suggests that sexual transmission may not play a significant role in transmission of HHV-8 among FSWs in Malindi.

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Section: Discussionmentioning

confidence: 55%

Prevalence and Risk Factors of Human Herpes Virus Type 8 (HHV-8), Human Immunodeficiency Virus-1 (HIV-1), and Syphilis among Female Sex Workers in Malindi, Kenya

Nzivo

Lwembe

Odari

et al. 2019

Interdisciplinary Perspectives on Infectious Diseases

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“…HHV-8 seroprevalence differs in different populations or risk groups and geographical regions reaching up to 50% prevalence in sub-Saharan Africa. In Europe and United States, HHV-8 prevalence is low among the general population but some population, such as people living with HIV and MSM have seroprevalence rates that reach 33-40% [4,[6][7][8]. In the Mediterranean, the prevalence ranges between 10 and 40% and is 0-20% in most parts of Asia [9].…”

Section: Introductionmentioning

confidence: 99%

Human herpesvirus 8 and Kaposi sarcoma: how should we screen and manage the transplant recipient?

Mikulska

Balletto

Mularoni

2021

Current Opinion in Infectious Diseases

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Purpose of review HHV-8-associated diseases are rare but potentially fatal in transplant recipients. Important differences exist in the distribution of HHV-8 seroprevalence, which might contribute to the lack of uniform approach to HHV-8. The aim of this review was to discuss recent updates in screening and management of HHV-8 after transplant. Recent findingsIncreasing attention has been given to the nonmalignant but potentially fatal inflammatory syndrome caused by HHV-8 in solid organ transplant (SOT) recipients. At-risk groups include HHV-8-IgG Dþ/Rtransplant and HHV-8-positive recipients. Severe cases of donor-derived HHV-8 disease, mainly Kaposi sarcoma, frequently without skin involvement and some diagnosed at autopsy, highlight the need to increase clinicians' awareness, to implement effective preemptive strategies and to perform rapid diagnosis. In HSCT setting, HHV-8-associated disorders are very rare.

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Human Herpes Virus Type 8 among Female-Sex Workers

Cited by 2 publications

References 47 publications

Prevalence and Risk Factors of Human Herpes Virus Type 8 (HHV-8), Human Immunodeficiency Virus-1 (HIV-1), and Syphilis among Female Sex Workers in Malindi, Kenya

Prevalence and Risk Factors of Human Herpes Virus Type 8 (HHV-8), Human Immunodeficiency Virus-1 (HIV-1), and Syphilis among Female Sex Workers in Malindi, Kenya

Human herpesvirus 8 and Kaposi sarcoma: how should we screen and manage the transplant recipient?

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