Human Herpesvirus 6 Infection in Hemodialysis and Peritoneal Dialysis Patients

Altay, Mustafa; Akay, Hatice; Unverdi, Selman; Altay, F. Aybala; Çeri, Mevlüt; Cesur, Salih; Duranay, Murat; Demiröz, Ali Pekcan

doi:10.3747/pdi.2010.00093

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…In a study conducted by Altay et al on 35 hemodialysis patients, 36 peritoneal dialysis patients, and 20 healthy volunteers, the rates of HHV-6 IgM positivity were 25.7% (9/35), 22.2% (8/35), and 10% (2/10), respectively. HHV-6 IgG seropositivity was significantly higher in hemodialysis patients at a rate of 20% compared to the peritoneal dialysis patients (5.6%) and the control group (0%) [11].…”

Section: Discussionmentioning

confidence: 91%

Prevalence of Human Herpes Virus 6 (HHV-6) in Patients with Hemodialysis

Tarhan¹,

Yılmaz²

2015

J Infect Dis Ther

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HHV-6 is the causative agent of exanthema subitum in children. The main modes of transmission of HHV-6 are body secretions such as infected saliva but it can be transmitted with blood and blood products that are infected with the virus. Therefore, it is thought that the immunocompromised hemodialysis patients who had multiple blood transfusions due to various reasons, and who collectively use devices such as hemodialysis machines are at risk for HHV-6 infection. The present study aimed to determine the incidence of HHV-6 infection in hemodialysis patients. Twenty-five healthy individuals that were matched with 25 hemodialysis patients in terms of gender and age were included in the study. The IgM and IgG sero-prevalence in the patient and control groups were investigated with the indirect fluorescence antibody method and HHV-6 DNA prevalence and the determination of variant types (variant A and variant B) were investigated with the PCR-RFLP molecular method. HHV-6 IgG and HHV-6 IgM antibody positivity ratios in the patient and control groups were 76% and 20% respectively. Out of 50 serum samples of hemodialysis patients and healthy individuals, HHV-6 DNA was positive in seven of 25 samples of hemodialysis patients (28%) and it was positive in eight of 25 samples of the control group (32%). Variant analysis was performed with the PCR-RFLP method in HHV-6 DNA positive hemodialysis patients and control patients. At the end of the analysis, while variant A was not detected in the patient and control groups, variant B was detected in a total of 15 individuals, including seven patients in the hemodialysis patient group and eight patients in the control group. In conclusion, the researchers believe that there is a need for controlled studies including more samples to determine the clinical importance of HHV-6 DNA and HHV-6 variants in hemodialysis patients.

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Section: Discussionmentioning

confidence: 91%

Prevalence of Human Herpes Virus 6 (HHV-6) in Patients with Hemodialysis

Tarhan¹,

Yılmaz²

2015

J Infect Dis Ther

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Detection of Human Herpes Virus type-6 in Patients Undergoing Hemodialysis

et al. 2018

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Aim: To investigate the epidemiology of human herpes virus type-6 (HHV-6) among hemodialysis (HD) patients. Materials & methods: DNA was extracted from plasma samples of 149 patients undergoing HD with no history of organ transplantation from 2011 to 2013. Presence of HHV-6 was investigated by using real-time PCR. Results: Diabetes (36.2%) and hypertension (28.8%) were two major factors for HD. The HHV-6 DNA was identified in eight patients (5.37%). Conclusion: This study is one of the few reports of HHV-6 infection among HD patients. In HD patient population, it is critical to improve standards of infection control in dialysis and expand treatment coverage. Furthermore, studies on clinical implications of HHV-6 infection in HD patients are crucial.

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Human Herpesvirus 6 Infection in Hemodialysis and Peritoneal Dialysis Patients

Cited by 2 publications

References 30 publications

Prevalence of Human Herpes Virus 6 (HHV-6) in Patients with Hemodialysis

Prevalence of Human Herpes Virus 6 (HHV-6) in Patients with Hemodialysis

Detection of Human Herpes Virus type-6 in Patients Undergoing Hemodialysis

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