Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis

Seyyedi, Noorossadat; Dehbidi, Gholamreza Rafiei; Karimi, Mozhgan; Asgari, Amir; Esmaeili, Babak; Zare, Farahnaz; Farhadi, Ali; Dabbaghmanesh, Mohammad Hossein; Saki, Forough; Behzad-Behbahani, Abbas

doi:10.1016/j.bjid.2019.10.004

Cited by 16 publications

(12 citation statements)

References 31 publications

(34 reference statements)

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“…Earlier studies suggest that people with hypothyroidism have impaired immunity and are at higher risk of viral infection. Patients with hypothyroidism are at a significant risk of Human herpes virus-6 (HHV-6) infection [ 140 , 141 , 142 ]. A significantly increased prevalence of remote cytomegalovirus [ 143 ] infection was observed in primary hypothyroid subjects [ 144 ].…”

Section: Disorders and Diseases Associated With Thyroid Dysfunctionmentioning

confidence: 99%

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Kumari

Chainy

Subudhi

2020

Heliyon

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Section: Disorders and Diseases Associated With Thyroid Dysfunctionmentioning

confidence: 99%

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Kumari

Chainy

Subudhi

2020

Heliyon

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“…Thus, we may only conclude that an undetermined species of HHV-6 is frequently present in thyroid. Further research is needed in this regard since it has been suggested that HHV-6 of the A species is likely associated with HT and possibly with other autoimmune diseases (8,(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

“…Enteroviruses (9)(10)(11), parvovirus B19 (12)(13)(14) and hepatitis C virus (HCV) (15,16) have all been associated with AITD. Among herpesviruses, Epstein-Barr virus (EBV) has been associated with GD (17)(18)(19), while human herpes virus 6 (HHV-6) and cytomegalovirus (CMV) may be associated with both HT and GD (20)(21)(22)(23)(24). The aforementioned viruses may produce subclinical disease and persistent infection at any age (25)(26)(27)(28)(29).…”

Section: Introductionmentioning

confidence: 99%

High Prevalence of Common Human Viruses in Thyroid Tissue

et al. 2022

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IntroductionEvidence points to viral infections as possible triggers of autoimmune thyroid disease (AITD), but little is known about the prevalence of common viruses in the thyroid gland. Using a novel approach based on virus enrichment in multiple cell lines followed by detection of the viral genome and visualization of viral proteins, we investigated the presence of multiple human viruses in thyroid tissue from AITD patients and controls.MethodsThyroid tissue was collected by core needle biopsy or during thyroid surgery from 35 patients with AITD (20 Graves’ disease and 15 Hashimoto’s thyroiditis). Eighteen thyroid tissue specimens from patients undergoing neck surgery for reasons other than thyroid autoimmunity served as controls. Specimens were tested for the presence of ten different viruses. Enteroviruses and human herpesvirus 6 were enriched in cell culture before detection by PCR and immunofluorescence, while the remaining viruses were detected by PCR of biopsied tissue.ResultsForty of 53 cases (75%) carried an infectious virus. Notably, 43% of all cases had a single virus, whereas 32% were coinfected by two or more virus types. An enterovirus was found in 27/53 cases (51%), human herpesvirus 6 in 16/53 cases (30%) and parvovirus B19 in 12/53 cases (22%). Epstein-Barr virus and cytomegalovirus were found in a few cases only. Of five gastroenteric virus groups examined, only one was detected in a single specimen. Virus distribution was not statistically different between AITD cases and controls.ConclusionCommon human viruses are highly prevalent in the thyroid gland. This is the first study in which multiple viral agents have been explored in thyroid. It remains to be established whether the detected viruses represent causal agents, possible cofactors or simple bystanders.

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“…Seyyedi et al have found HHV-6A DNA in serum samples of 57 of 151 patients (38%) with HT, which was significantly more than in patients with non-autoimmune thyroid disorders (P = 0.001) ( 14 ). Contrary to their study, we did not use serum samples.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the association between human herpes virus 6 (HHV-6) and Hashimoto's thyroiditis

Molla¹,

Kalbasi²,

Kalantari³

et al. 2022

IJM

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Background and Objectives: Hashimoto's thyroiditis is a chronic inflammation and an autoimmune disease of the thyroid gland that causes hypothyroidism. Genetic, internal, and environmental factors are the causes of this disease. Because human herpes viruses such as herpesvirus type 6 (HHV-6) are involved in some autoimmune disorders, they may also play a role in causing this disease. This study aimed to evaluate the association between human herpes virus 6 (HHV-6) with Hashimoto's thyroiditis. Materials and Methods: In the present study, 64 samples of thyroid paraffin tissue including 32 samples of thyroid paraffin tissue of healthy individuals as control, and 32 samples of thyroid paraffin tissue of Hashimoto's thyroiditis patients were taken from the pathology department of Loghman Hakim Hospital in Tehran. A questionnaire collected demographic infor- mation of patients. After DNA extraction from the samples, the nested-PCR technique was performed using specific primers for HHV-6. Results: Totally, the HHV6-DNA was found in 34.4% of thyroid tissues of healthy individuals (81.8% female and 18.2% male) and 46.9% of patients with Hashimoto's thyroiditis (73.3% female and 26.7% male). It was found that this difference in virus frequency between the two groups was not statistically significant (P value=0.309). There was also no statistically significant relationship between the prevalence of human herpesvirus type 6 and age or sex. Conclusion: Based on the present study, the number of HHV-6-infected individuals in Hashimoto's patients and controls did not differ significantly; therefore, HHV-6 appears not to be associated with Hashimoto's thyroiditis.

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Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis

Cited by 16 publications

References 31 publications

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

High Prevalence of Common Human Viruses in Thyroid Tissue

Evaluation of the association between human herpes virus 6 (HHV-6) and Hashimoto's thyroiditis

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