Human herpesvirus 7 in pediatric hematopoietic stem cell transplantation

Khanani, Muhammad Faisal; Al-Ahmari, Ali; Tellier, Raymond; Allen, Upton; Richardson, Susan E.; Doyle, John; Gassas, Adam

doi:10.1002/pbc.20829

Cited by 15 publications

(10 citation statements)

References 21 publications

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“…In studies on both adult and pediatric patients HHV-7 viremia post-transplant is ranging from 10% to 57% [Hubacek et al, 2008]. Nevertheless, in another study on pediatric stem cell recipients, the incidence of HHV-7 was found to be 5.5% [Khanani et al, 2007].…”

Section: Human Herpesvirus-6/human Herpesvirus-7 Basic Characteristicsmentioning

confidence: 95%

“…HHV-6A, HHV-6B, and HHV-7 are ubiquitous and remain latent in T cells after the primary infection and then can be reactivated in an immunocompromised host [Khanani et al, 2007]. The phenomenon of HHV-6 chromosomal integration (CI), a latent state of the virus in the chromosome, should be kept in mind as an alternative cause of HHV-6 detection in suspected cases [Ljungman et al, 2008].…”

Section: Human Herpesvirus-6/human Herpesvirus-7 Basic Characteristicsmentioning

confidence: 99%

“…After allogeneic hematopoietic cell transplantation, HHV-7 has been reported as a cause of severe central nervous system disease [Castagnola et al, 2008]. In addition, HHV-7 was associated with severe GVHD and sepsis secondary to severe immunosuppression after transplantation from matched unrelated donors [Khanani et al, 2007]. The role of HHV-7 has been poorly defined in hematopoietic cell transplant recipients [Ljungman et al, 2008].…”

Section: Clinical Symptomsmentioning

confidence: 99%

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Hematopoietic cell transplantation and emerging viral infections

Chatzidimitriou¹,

Gavriilaki²,

Sakellari³

et al. 2010

Journal of Medical Virology

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Viral infections remain important causes of morbidity and mortality in hematopoietic cell transplant recipients. More recent developments in preparative regimens and graft manipulations, as well as the control of well-recognized post-transplant infections by the introduction of prophylaxis and preemptive strategies, have influenced the timing and the epidemiology of infections. As new pathogens, such as human metapneumovirus (HMPV), human bocavirus, human coronaviruses HCoV-NL63 and HCoV-HKU1, human herpesviruses HHV-6 and HHV-7, and polyomaviruses, have emerged, it is fundamental to determine the significance of the newly discovered viruses and their role in the transplantation field. This article summarizes recent data on epidemiology and laboratory diagnosis of new pathogens, as well as clinical features and management of the associated infectious complications. J. Med. Virol. 82:528-538, 2010. (c) 2010 Wiley-Liss, Inc.

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Section: Human Herpesvirus-6/human Herpesvirus-7 Basic Characteristicsmentioning

confidence: 95%

Section: Human Herpesvirus-6/human Herpesvirus-7 Basic Characteristicsmentioning

confidence: 99%

Section: Clinical Symptomsmentioning

confidence: 99%

See 1 more Smart Citation

Hematopoietic cell transplantation and emerging viral infections

Chatzidimitriou¹,

Gavriilaki²,

Sakellari³

et al. 2010

Journal of Medical Virology

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“…These include CNS disease [53], myelosuppression [54], aGVHD [55], and allograft dysfunction and rejection [56]. Data from a number of studies suggest a potential indirect effect of HHV-7 to increase rates of CMV reactivation and disease in HCT [57] and SOT [58,59] recipients, but this is not a consistent finding [52].…”

Section: Human Herpesvirusmentioning

confidence: 99%

Roseoloviruses in transplant recipients: clinical consequences and prospects for treatment and prevention trials

Hill

Zerr

2014

Current Opinion in Virology

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Roseoloviruses frequently reactivate in transplant recipients. We review the impact of Roseoloviruses in transplant recipients and highlight research priorities. Human herpesvirus 6A (HHV-6A) and HHV-6B were recently classified as distinct species with important differences. Both viruses can result in inherited chromosomally integrated HHV-6, which may cause complications after transplant. HHV-6B is the primary species associated with disease and appears to have pleiotropic effects on the central nervous system. Small preemptive and prophylactic studies have not shown a statistically significant impact on HHV-6 disease. Although Roseoloviruses are associated with diverse complications in transplant patients, studies providing strong evidence for a causal role are lacking. Trials focusing on prevention and treatment will be important to inform the significance of Roseolovirus reactivation.

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“…16,19 Moreover, HHV-7 was associated with severe GvHD and sepsis secondary to severe immunosuppression after HSCT from matched unrelated donors. 20 HHV-8 has been associated with the development of visceral Kaposi's sarcoma or lymphomas in immunocompromised patients, [21][22][23] and de Medeiros et al 24 have reported a case of Kaposi's sarcoma after allogeneic HSCT. However, a survey on the presence of serum HHV-8 DNA after bone marrow transplantation performed in 187 Italian HSCT donor-recipient pairs did not show any HHV-8-related complications after a median of 6 years of follow-up.…”

Section: Allogeneic Hsctmentioning

confidence: 99%