Human Herpesvirus 8 DNA Sequences in Blistering Skin From Patients With Pemphigus

Memar, Omeed

doi:10.1001/archderm.1997.03890460069008

Cited by 65 publications

(37 citation statements)

References 2 publications

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“…5 Recently, HHV-8 DNA sequences were detected in 4 of 6 skin lesions from patients with pemphigus vulgaris and in all 6 skin lesions from patients with pemphigus foliaceus. 18 These findings could not be explained by a crosscontamination of DNA according to the DNA sequencing analysis, and these results contrast with our own, which suggest that there is no link between HHV-8 and…”

Section: Commentcontrasting

confidence: 89%

Prevalence of Human Herpesvirus 8 Infection Measured by Antibodies to a Latent Nuclear Antigen in Patients With Various Dermatologic Diseases

Dupin¹,

Marcelin²,

Gorin³

et al. 1998

Arch Dermatol

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Section: Commentcontrasting

confidence: 89%

Prevalence of Human Herpesvirus 8 Infection Measured by Antibodies to a Latent Nuclear Antigen in Patients With Various Dermatologic Diseases

Dupin¹,

Marcelin²,

Gorin³

et al. 1998

Arch Dermatol

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“…Other clinical conditions have also been connected with KSHV infections, including angiosarcoma (333), angiolymphoid hyperplasia with eosinophilia (211), skin carcinomas (squamous cell carcinoma and Bowen disease) in immunosuppressed individuals (416), sarcoidosis (131), multiple myeloma (MM) (427), pemphigus vulgaris and pemphigus foliaceus (337,338), AIDS-associated immunoblastic lymphoma (149), primary central nervous system lymphoma (190), posttransplantation lymphoproliferative disorders (244,329), and pulmonary inflammatory myofibroblastic tumor (191). A condition of immunocompetent patients named germinotropic lymphoproliferative disorder, in which KSHV-and EBV-coinfected B-cell plasmablasts invade lymphoid follicle germinal centers, has also been described (139).…”

Section: Other Kshv-associated Diseasesmentioning

confidence: 99%

Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis

Dourmishev

Palmeri

et al. 2003

Microbiol Mol Biol Rev

309

367

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Kaposi's sarcoma had been recognized as unique human cancer for a century before it manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, in 1994 by using representational difference analysis, a subtractive method previously employed for cloning differences in human genomic DNA, was a fitting harbinger for the powerful bioinformatic approaches since employed to understand its pathogenesis in KS. Indeed, the discovery of KSHV was rapidly followed by publication of its complete sequence, which revealed that the virus had coopted a wide armamentarium of human genes; in the short time since then, the functions of many of these viral gene variants in cell growth control, signaling apoptosis, angiogenesis, and immunomodulation have been characterized. This critical literature review explores the pathogenic potential of these genes within the framework of current knowledge of the basic herpesvirology of KSHV, including the relationships between viral genotypic variation and the four clinicoepidemiologic forms of Kaposi's sarcoma, current viral detection methods and their utility, primary infection by KSHV, tissue culture and animal models of latent- and lytic-cycle gene expression and pathogenesis, and viral reactivation from latency. Recent advances in models of de novo endothelial infection, microarray analyses of the host response to infection, receptor identification, and cloning of full-length, infectious KSHV genomic DNA promise to reveal key molecular mechanisms of the candidate pathogeneic genes when expressed in the context of viral infection

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“…A group studying pemphigus patients without HIV in Texas (193,194) found HHV-8 DNA in the lesional skin of four of six patients with pemphigus vulgaris and six of six patients with pemphigus foliaceus who were studied. The PCR DNA sequences differed among all these patients.…”

Section: Hhv-8 In Patients With Pemphigusmentioning

confidence: 99%

Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases

Ablashi¹,

Chatlynne²,

Whitman³

et al. 2002

Clin Microbiol Rev

278

182

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Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), discovered in 1994, is a human rhadinovirus (gamma-2 herpesvirus). Unlike other human herpesviruses (herpes simplex virus, Epstein-Barr virus, varicella-zoster virus, cytomegalovirus, HHV-6, and HHV-7), it is not widespread in the general population and has many unique proteins. HHV-8 is strongly associated with all subtypes of Kaposi's sarcoma (KS), multicentric Castleman's disease, and a rare form of B-cell lymphoma, primary effusion lymphoma. In addition, HHV-8 DNA sequences have been found in association with other diseases, but the role of the virus in these diseases is largely unconfirmed and remains controversial. The seroprevalence of HHV-8, based on detection of latent and lytic proteins, is 2 to 5% in healthy donors except in certain geographic areas where the virus is endemic, 80 to 95% in classic KS patients, and 40 to 50% in HIV-1 patients without KS. This virus can be transmitted both sexually and through body fluids (e.g., saliva and blood). HHV-8 is a transforming virus, as evidenced by its presence in human malignancies, by the in vitro transforming properties of several of its viral genes, and by its ability to transform some primary cells in culture. It is not, however, sufficient for transformation, and other cofactors such as immunosuppressive cytokines are involved in the development of HHV-8-associated malignancies. In this article, we review the biology, molecular virology, epidemiology, transmission, detection methods, pathogenesis, and antiviral therapy of this newly discovered human herpesvirus

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Human Herpesvirus 8 DNA Sequences in Blistering Skin From Patients With Pemphigus

Cited by 65 publications

References 2 publications

Prevalence of Human Herpesvirus 8 Infection Measured by Antibodies to a Latent Nuclear Antigen in Patients With Various Dermatologic Diseases

Prevalence of Human Herpesvirus 8 Infection Measured by Antibodies to a Latent Nuclear Antigen in Patients With Various Dermatologic Diseases

Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis

Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases

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