Human Herpesvirus--8 in Peruvian Blood Donors: A Population with Hyperendemic Disease?

Mohanna, Salim; Portillo, Jose‐Andres C.; Carriquiry, Gabriela; Vidal, J; Ferrufino, Juan Carlos; Sánchez, Juvenal; Bravo, Francisco; Gotuzzo, Eduardo

doi:10.1086/511044

Cited by 26 publications

(27 citation statements)

References 24 publications

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“…In Latin America, HHV-8 prevalence in the general population of Latin America has been described as low(12, 13), but rural populations with a high prevalence of antibodies to HHV-8 have been described in Brazil(14) and Peru(15). The moderate seroprevalence of HHV-8 among HIV-negative MSM in our study suggests that the previous reports of high HHV-8 seroprevalence and KS incidence(16) among the persons in Peru suggests that there may be substantial heterogeneity in the prevalence of HHV-8 infection among residents of Peru, and bears further study.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Correlates of Human Herpesvirus 8 Infection Among Peruvian Men Who Have Sex With Men

Guanira¹,

Casper²,

Lama³

et al. 2008

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background Infection with human herpesvirus 8 (HHV-8) is common among men who have sex with men (MSM) in North America and Europe, and is also found to be endemic in some regions of South America. Little is known about HHV-8 prevalence and its correlates among MSM in the Andean region. Methods We assessed HHV-8 seroprevalence among 497 MSM recruited for the 2002 Peruvian HIV sentinel surveillance program using a combined HHV-8 enzyme immunoassay and immunofluorescence assay algoritm. Logistic regression was used to estimate Odds Ratios (OR) and their 95% confidence intervals (CI) to determine the association between selected covariates and HHV-8 seropositivity. Results 483 (97%) of 497 men had stored sera and demographic data available for analysis. 131 (66.5%, 95% CI 63.1%-69.9%) of 197 HIV-infected and 80 (26.7%, 95% CI 24.4%-29.0%) of 300 HIV-uninfected MSM had serologic evidence of HHV-8 infection. Factors independently associated with HHV-8 infection were education <12 years (OR 1.7, 95% CI 1.1-2.7), anal receptive sex with the last partner (OR 2.0, 95% CI 1.2-3.3), self-reported STI symptoms during the last year (OR: 1.9, 95% CI 1.2-3.0), and co-infection with HIV (OR 4.2, 95% CI 2.8-6.4) and Chronic Hepatitis B (OR 4.9, 95% CI 1.5-15.8). MSM with long-standing HIV infection were more likely to have serologic evidence of HHV-8 infection when compared to men with recently-acquired HIV (OR: 3.8, 95% CI 1.7-9.1). Conclusions HHV-8 infection is common among both HIV-infected and negative MSM in Lima, Peru. HHV-8 seropositivity is correlated with anal receptive sex, self-reported STI symptoms, and HIV infection among these MSM, and thus appears to be sexually transmitted. HHV-8 infection appears to be acquired after HIV infection, suggesting that future studies should evaluate the mode of HHV-8 transmission and prevention strategies among HIV-infected MSM.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Correlates of Human Herpesvirus 8 Infection Among Peruvian Men Who Have Sex With Men

Guanira¹,

Casper²,

Lama³

et al. 2008

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…HHV-8 prevalence ranges from 0.2% in Japan, 0-15% in the USA and the UK, up to >50% in some African countries [16,17]. There is a wide range of variations in HHV-8 infection in South America [18]. A few studies focusing on small study populations have been carried out in China.…”

Section: Introductionmentioning

confidence: 99%

Human herpesvirus-8 in northwestern China: epidemiology and characterization among blood donors

Wang

Zhang

et al. 2010

Virol J

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Background: Human herpes virus 8 (HHV-8) is the etiologic agent associated with development of classical, AIDSrelated, iatrogenic, and endemic Kaposi's sarcoma (KS). Several studies provide strong evidence that HHV-8 can be transmitted by blood transfusion. We evaluated the seroprevalence and potential risk factors of HHV-8 infection in blood donors in one region. We surveyed HHV-8 infection among 4461 blood donors in Xinjiang, China, a unique endemic area for HHV-8 and KS. Results: The HHV-8 seroprevalence was higher in local minority groups which comprise most KS cases in China, than in Han people. HHV-8 prevalence was 18.6% in the Han ethnic group, 25.9% in Uygur subjects, 29.2% in Kazak subjects, 36.8% in Mongolian subjects, and 21.9% in other ethnic groups. In several subgroups, the time of donation of whole blood seemed to be a risk factor. In HHV-8-seropositive subjects, a larger fraction of local minorities (23.9%) had high HHV-8 titers than that of Han subjects (9.2%). HHV-8 infection was associated with ethnicity and residence. Conclusion: HHV-8 seroprevalence was significantly high among blood donors in Xinjiang, where the prevalence of KS correlates with HHV-8 prevalence and titers in Uygur and Kazak ethnic groups. Blood exposure represented by the frequency of blood donation indicated a possible blood-borne transmission route of HHV-8 in Xinjiang. Detecting anti-HHV-8 antibodies before donation in this region is therefore important.

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“…Recent studies demonstrated that classic KS is common in Peru and that AIDS-KS incidence is increasing because of the spread of HIV infection ( 10 , 11 ). Classic and epidemic KS occurred in patients of Amerindian origin (Quechuas) and in mestizos, reflecting the multiethnic origin of the Peruvian population.…”

mentioning

confidence: 99%

Human Herpesvirus 8 Genotype E in Patients with Kaposi Sarcoma, Peru

Cassar¹,

Blondot²,

Mohanna³

et al. 2010

Emerg. Infect. Dis.

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Human Herpesvirus--8 in Peruvian Blood Donors: A Population with Hyperendemic Disease?

Cited by 26 publications

References 24 publications

Prevalence and Correlates of Human Herpesvirus 8 Infection Among Peruvian Men Who Have Sex With Men

Prevalence and Correlates of Human Herpesvirus 8 Infection Among Peruvian Men Who Have Sex With Men

Human herpesvirus-8 in northwestern China: epidemiology and characterization among blood donors

Human Herpesvirus 8 Genotype E in Patients with Kaposi Sarcoma, Peru

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