Human herpesvirus 8 infection

Jenson, Hal B.

doi:10.1097/00008480-200302000-00014

Cited by 11 publications

(4 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12,64,65 It is common in parts of Africa and in Italy, occurring in up to 15% of adult populations in North America and Europe. 66 Primary infection in healthy children produces a fever and morbilliform rash. Like all herpesviruses, HHV-8 infection persists for the life of the host.…”

Section: Hhv-8 Virusmentioning

confidence: 99%

Kaposi sarcoma: A continuing conundrum

Schwartz

Micali

Nasca

et al. 2008

Journal of the American Academy of Dermatology

203

212

View full text Add to dashboard Cite

Section: Hhv-8 Virusmentioning

confidence: 99%

Kaposi sarcoma: A continuing conundrum

Schwartz

Micali

Nasca

et al. 2008

Journal of the American Academy of Dermatology

203

212

View full text Add to dashboard Cite

“…This lymphotropic and oncogenic virus is required for the development of Kaposi sarcoma (KS), 6 and its detection in adults with MCD suggests that it may also play a role in MCD pathogenesis. 7 Moreover, MCD occurs preferentially in patients with underlying immunodeficiency, such as HIV infection or immunosuppressive therapy, consistent with impaired immunity to HHV-8 leading to MCD. 4 Interestingly, HHV-8-driven MCD has never been identified in children.…”

mentioning

confidence: 99%

Multicentric Castleman Disease in an HHV8-Infected Child Born to Consanguineous Parents With Systematic Review

et al. 2012

View full text Add to dashboard Cite

Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.

show abstract

“…24 The prevalence of HHV-8 among children in Central Africa, Brazil, and South Texas has been reported to range from 3% to more than 50%, suggesting that transmission occurs horizontally among children. 25 Establishing a diagnosis of PEL requires the demonstration of HHV-8 DNA in the neoplastic cells. This can be accomplished through direct detection of HHV-8 DNA from tissue samples using polymerase chain reaction (PCR) amplification or Southern blot analysis.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and Management of Primary Effusion Lymphoma in the Immunocompetent and Immunocompromised Hosts

Ammari

Mollberg

Abdelhady³

et al. 2013

Thorac cardiovasc Surg

View full text Add to dashboard Cite

Primary effusion lymphoma (PEL) is an uncommon non-Hodgkin lymphoma associated with human herpes virus-8 (HHV-8) that grows mainly in serous body cavities. The most common presentation of PEL is that of a young immunocompromised male with shortness of breath, as the pleural cavity is most commonly affected. Diagnosis is primarily based on fluid cytology in which PEL cells display variable morphology and a null lymphocyte immunophenotype; however, evidence of HHV-8 infection within the neoplastic cell is essential. Patients have commonly been treated with systemic multidrug chemotherapy and antiretroviral therapy if they were HIV positive or were immunocompromised for other reasons. In the immunocompetent patient, there have been no agreed-upon pathways for management of this condition. Progression of disease is common and median survival is approximately 6 months. Novel intrapleural treatments with antiviral agents such as intracavity cidofovir have shown to be effective in controlling local disease, and ongoing clinical trials may provide some promise in the treatment for this condition.

show abstract

Human herpesvirus 8 infection

Cited by 11 publications

References 144 publications

Kaposi sarcoma: A continuing conundrum

Kaposi sarcoma: A continuing conundrum

Multicentric Castleman Disease in an HHV8-Infected Child Born to Consanguineous Parents With Systematic Review

Diagnosis and Management of Primary Effusion Lymphoma in the Immunocompetent and Immunocompromised Hosts

Contact Info

Product

Resources

About