Human Herpesvirus Type 8-positive Multicentric Castleman Disease

Melikyan, AL; Егорова, Е К; Julhakyan, Hunan; Kovrigina, А М; Vg, Savchenko

doi:10.1016/j.clml.2016.03.009

Cited by 7 publications

(9 citation statements)

References 26 publications

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“…cases is exceptional. 2,3 The present case series highlights some characteristic findings to reaffirm the cytopathological diagnostic criteria of the HHV8-related lymphoproliferative disorders, stressing the crucial role of the appropriate technical processing of effusion fluids to obtain the best outcome from these samples. Aliquots were collected in 50-mL tubes for centrifugation and further processing depending on the techniques.…”

Section: Introductionsupporting

confidence: 61%

“…Some entities (eg, PEL) may be diagnosed only on serous fluids due to the frequent absence of lymphadenopathies, conferring cytopathology a central role in the management of these atypical B‐cell lymphomas. Other forms (eg, CD) are not included in the classic differential diagnosis of the lesions, causing cavity effusions since serosal colonisation in these cases is exceptional . The present case series highlights some characteristic findings to reaffirm the cytopathological diagnostic criteria of the HHV8‐related lymphoproliferative disorders, stressing the crucial role of the appropriate technical processing of effusion fluids to obtain the best outcome from these samples.…”

Section: Introductionmentioning

confidence: 56%

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The spectrum of the cytopathological features of primary effusion lymphoma and human herpes virus 8‐related lymphoproliferative disorders

et al. 2020

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Introduction: Human herpes virus 8-related lymphoproliferative disorders are a complex and heterogeneous group of entities and some of them are eminently diagnosed by cytopathology. In a routine laboratory, these lesions account for less than 1% of the effusion fluids samples. However, they represent up to 30% of all the lymphoma diagnosis from effusion cytological samples and their consideration in the diagnostic flow chart is mandatory, especially in human immunodeficiency virus-positive patients. Methods: A retrospective series of cytological specimens from cavity effusions (n = 605) were analysed. Five human herpes virus 8-related lymphoproliferative processes were recruited. A combination of morphological criteria (enhanced with May-Grünwald Giemsa staining), cell block-based immunocytochemistry and flow cytometry were undertaken for final characterisation. Results: The identification of malignant cells may be difficult. Some specimens are particularly rich, easily leading to suspect a lymphoproliferative process, whereas in other cases, the presence of abundant reactive mesothelial cells, histiocytes, neutrophils, small reactive T and B lymphocytes may obscure the neoplastic process. The biological behaviour may be very heterogeneous and a standardised therapy for these cases is still lacking, although some patients may benefit from antiretroviral therapy in a human immunodeficiency virus setting. Conclusions: The present case series highlights some characteristic findings of these entities to reaffirm useful cytopathological diagnostic criteria, stressing the crucial role of the appropriate technical processing of effusion fluids to obtain the best performances.

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Section: Introductionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 56%

The spectrum of the cytopathological features of primary effusion lymphoma and human herpes virus 8‐related lymphoproliferative disorders

et al. 2020

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“…Human Herpes Simplex Virus 8 (HHV8) associated MCCD is a very aggressive disease [ 8 ] occurring in immunocompromised individuals due to the viral trigger and constitutes 65% of MCCD.…”

Section: Discussionmentioning

confidence: 99%

Castleman disease: Case series of two surgical patients from different ends of the disease spectrum with literature review

Raj

Suresh

2018

International Journal of Surgery Case Reports

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“…KSHV is known to cause Kaposi's sarcoma, a form of skin cancer, often seen in HIV‐infected individuals and known as an Acquired Immunodeficiency Syndrome defining event. In both HIV‐negative and HIV‐positive patients it is a known cause of (multicentric) Castleman's disease 13 …”

Section: Introductionmentioning

confidence: 99%

Clinically relevant DNA viruses in pregnancy

2022

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Infections by DNA viruses during pregnancy are associated with increased health risks to both mother and fetus. Although not all DNA viruses are related to an increased risk of complications during pregnancy, several can directly infect the fetus and/or cause placental dysfunction. During Non‐Invasive Prenatal Testing analysis, the presence of viral DNA can be detected, theoretically allowing screening early in pregnancy. Although treatment options are currently limited, this might rapidly change in the near future. It is therefore important to be aware of the potential impact of these viruses on feto‐maternal health. In this manuscript we provide a brief introduction into the most commonly detected DNA viruses in human cell‐free DNA sequencing experiments and their pathogenic potential during pregnancy.

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Human Herpesvirus Type 8-positive Multicentric Castleman Disease

Cited by 7 publications

References 26 publications

The spectrum of the cytopathological features of primary effusion lymphoma and human herpes virus 8‐related lymphoproliferative disorders

The spectrum of the cytopathological features of primary effusion lymphoma and human herpes virus 8‐related lymphoproliferative disorders

Castleman disease: Case series of two surgical patients from different ends of the disease spectrum with literature review

Clinically relevant DNA viruses in pregnancy

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