Human histopathology of PASCAL laser burns

Paulus, Yannis M.; Kaur, Khushmit; Egbert, Peter R.; Blumenkranz, Mark S.; Moshfeghi, Darius M.

doi:10.1038/eye.2013.100

Cited by 15 publications

(18 citation statements)

References 5 publications

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“…Histopathology evaluation by Paulus et al (2013) reported preservation of the inner nuclear layer of RNFL post PASCAL laser. Previous OCT study, describe transient RNFL thickening occurs immediately after argon laser treatment and may last for up to 6 months (Lee et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Retinal Nerve Fiber Layer Thickness Post-Laser Treatment in Diabetic Retinopathy: Argon versus Pattern Scanning Laser

Maimunah¹,

Rahman²,

Othman³

et al. 2016

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ABSTRAK Rawatan konvensional laser argon menyebabkan ketebalan sementara pada lapisan saraf retina (RNFL). Tetapi kesan dari 'pattern scanning laser' (PASCAL) tidak banyak diketahui. Kajian ini dilakukan untuk membandingkan kesan selepas konvensional laser argon dibandingkan dengan & Health 2016;11(2): 199-208 Maimunah M. et al. The principle by which the laser exerts its therapeutic effects relies on the destruction of the outer retina. This reduces the oxygen demand while maintaining a constant oxygen input. Laser burns may also serve as physiological windows through which oxygen diffuses from the choroid, increasing vitreous oxygenation and induced vasoconstriction (VelezMontota et al. 2010). However, despite the efficacy for preventing severe visual loss, laser PRP is often associated with substantial ocular side effects, such as ABSTRACT Conventional argon laser causes transient thickening of retinal nerve fibre layer (RNFL). The effect of pattern scanning laser (PASCAL) has not been well described. We compared the immediate changes in peripapillary RNFL thickness post-panretinal photocoagulation between conventional argon lasers and PASCAL in patients with diabetic retinopathy changes. A total of 32 subjects were recruited. There were 16 patients in the argon group and 16 patients in PASCAL group. Diabetic patients were recruited from Ophthalmology Clinic, Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Complete eye examinations and fundus photographs were performed at baseline prior to laser treatment, and post-laser treatment at two and four months. RNFL thickness was measured using time domain optical coherence tomography. Both groups were comparable with respect to clinical characteristics and demographics. There was no significant difference in average RNFL thickness between the two groups prior to treatment (p= 0.323). RNFL post-laser treatment for patients receiving conventional argon laser remained unchanged with no significant differences in all quadrants at any time-point (two and four months). However, for the PASCAL group, significant thickening occurred at four months for average RNFL and the inferior quadrant (p <0.05). The other quadrants similarly demonstrated increasing thickness at four months but this did not reach statistical significance. Transient RNFL thickening occurs in both conventional and PASCAL laser patients. The PASCAL laser induces a greater increase in RNFL thickness than the argon laser group. Important events, such as laser eye treatments and even type of laser used, are worthy of consideration when evaluating RNFL.

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Section: Discussionmentioning

confidence: 99%

Retinal Nerve Fiber Layer Thickness Post-Laser Treatment in Diabetic Retinopathy: Argon versus Pattern Scanning Laser

Maimunah¹,

Rahman²,

Othman³

et al. 2016

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“…This resulted in the histological preservation of the INL and GCL, as compared to conventional photocoagulation cases which sometimes reveal INL and ONL loss. 58 The NAVILAS laser is a targeted laser system that allows a physician to pre-select focal areas for laser treatment. The system then provides automated delivery of the laser to these pre-selected areas while using eye tracking to ensure that the laser placement is exact.…”

Section: Pattern Scanning and Navigated Laser Systemsmentioning

confidence: 99%

Side-Effects and Complications of Laser Treatment in Diabetic Retinal Disease

Deschler

Sun

Silva

2014

Seminars in Ophthalmology

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Laser treatment for diabetic retinopathy was the first intraocular treatment to provide a highly effective means for preventing visual loss in patients with diabetes. Although inherently destructive, laser treatment is remarkably effective in preventing visual loss and preserving vision long-term. This review will describe briefly the current techniques and discuss in detail the reported side-effects and potential complications of laser treatment of diabetic retinal disease.

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“…Melanin absorbs broadly across the visual spectrum. Laser-induced injury pathology has been studied on eyes scheduled for enucleation [42,43] , and with animal models [44,45,46] .…”

Section: Laser-tissue Interactionsmentioning

confidence: 99%

Non-Therapeutic Laser Retinal Injury

Kalra

Heisel

Paulus

2019

International Journal of Ophthalmic Research

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BACKGROUND: As lasers have become an increasingly important component of commercial, industrial, military, and medical applications, reported incidents of non-therapeutic laser eye injuries have increased. The retina is particularly vulnerable due to the focusing power and optical transparency of the eye. Continued innovations in laser technology will likely mean that lasers will play an increasingly important and ubiquitous role throughout the world. Critical evaluation should thus be paid to ensure that non-therapeutic injuries are minimized, recognized, and treated appropriately. METHODS: A comprehensive literature review on the PubMed database was conducted to present case reports and case series representative of the variety of laser eye injuries in different injury circumstances, tissue types, and biological damage mechanisms. RESULTS: A general summary of non-therapeutic laser retina injuries is presented, including information about growth of the industry, increasingly accessible online markets, inconsistent international regulation, laser classifications, laser wavelengths, and laser power, mechanisms of tissue injury, and a demonstration of the variety of settings in which injury may occur. Finally, 68 cases found in the literature are summarized to illustrate the presentations and outcomes of these patients. CONCLUSIONS: As non-therapeutic laser eye injuries increase in frequency, there is a greater need for public health, policy, diagnosis, and treatment of these types of injuries.

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Human histopathology of PASCAL laser burns

Cited by 15 publications

References 5 publications

Retinal Nerve Fiber Layer Thickness Post-Laser Treatment in Diabetic Retinopathy: Argon versus Pattern Scanning Laser

Retinal Nerve Fiber Layer Thickness Post-Laser Treatment in Diabetic Retinopathy: Argon versus Pattern Scanning Laser

Side-Effects and Complications of Laser Treatment in Diabetic Retinal Disease

Non-Therapeutic Laser Retinal Injury

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