2008
DOI: 10.1002/bjs.5883
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Human in vivo cellular response to a cross-linked acellular collagen implant

Abstract: The collagen implant demonstrated excellent biocompatibility and resistance to degradation in most patients. However, fibrovascular in-growth and ECM deposition were limited. This implant has excellent potential for soft tissue reinforcement.

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Cited by 59 publications
(49 citation statements)
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“…Anecdotally, the solution Permacol TM is stored in has been described akin to feline urine. When examined in patients for the prevention of parastomal herniation, 15 patients had Permacol TM placed in the anterior abdominal wall [21] and 11 patients underwent stoma implant biopsies. At a median of 7 months, the human cellular response demonstrates minimal inflammatory response and minimal degradation of the bioprosthetic material.…”
Section: Permacol Tmmentioning
confidence: 99%
“…Anecdotally, the solution Permacol TM is stored in has been described akin to feline urine. When examined in patients for the prevention of parastomal herniation, 15 patients had Permacol TM placed in the anterior abdominal wall [21] and 11 patients underwent stoma implant biopsies. At a median of 7 months, the human cellular response demonstrates minimal inflammatory response and minimal degradation of the bioprosthetic material.…”
Section: Permacol Tmmentioning
confidence: 99%
“…Crosslinking increases the resistance of collagen to enzymatic breakdown [11], but still permits cellular and vascular ingrowth [12][13][14]. Clinical data on Permacol's effectiveness in closing abdominal wall defects have been encouraging.…”
Section: Introductionmentioning
confidence: 96%
“…Multiple tissue as well as mesh techniques have been described to reinforce a weakened floor postpelvic surgery. [14][15][16][17][18][19] If sufficient levator muscle tissue remains, the pelvic floor is reapproximated with multiple absorbable sutures. Other ways of reinforcing the pelvic floor in cases where musculature cannot be closed include myocutaneous flaps and mesh techniques.…”
Section: Discussionmentioning
confidence: 99%