Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor

Santi, Mauro De; Annibalini, Giosuè; Barbieri, Elena; Villarini, Anna; Vallorani, Luciana; Contarelli, Serena; Berrino, Franco; Stocchi, Vilberto; Brandi, Giorgio

doi:10.1007/s13402-015-0263-3

Cited by 36 publications

(45 citation statements)

References 30 publications

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“…ProIGFs activate either the MAPK or the PI3K/AKT arm of IGF-1R downstream signaling in a cell type-dependent manner. Contrary to transgenic mice overexpressing IGF-1Ea, AKT phosphorylation is affected by glycosylated pro-IGF-1Ea in MCF-7 human breast (adenocarcinoma) epithelial cells [27,29]. However, among proIGFs, we cannot exclude the existence of distinct downstream signaling pathways that are divergent from that of mature IGF-1.…”

Section: Igf-1 Signaling and Emt Activation In Breast Lung And Gmentioning

confidence: 92%

“…Intracellular IGF-1 seems to be mainly expressed as proIGF-1 that is extracellularly converted into mature IGF-1 [26,27]. Although IGF-1’s biological activity is mainly exerted by the mature peptide, recent evidence suggests that the various prohormones exert functional roles [28].…”

Section: The Igf Systemmentioning

confidence: 99%

“…In fact, it is now recognized that ERK/MAPK and IRS-1/PI3K/AKT/GSK-3β, the major IGF-1R signaling transduction pathways, are involved in IGF-1-mediated EMT activation in BC. Interestingly, in vitro studies showed that also human proIGFs can promote cell proliferation and migration in different human cell types, both normal and cancer cells including BC [27,29]. In fact, De Santi et al demonstrated that proIGFs induce BC cell proliferation via IGF-1R activation [27].…”

Section: Igf-1 Signaling and Emt Activation In Breast Lung And Gmentioning

confidence: 99%

“…Interestingly, in vitro studies showed that also human proIGFs can promote cell proliferation and migration in different human cell types, both normal and cancer cells including BC [27,29]. In fact, De Santi et al demonstrated that proIGFs induce BC cell proliferation via IGF-1R activation [27]. ProIGFs activate either the MAPK or the PI3K/AKT arm of IGF-1R downstream signaling in a cell type-dependent manner.…”

Section: Igf-1 Signaling and Emt Activation In Breast Lung And Gmentioning

confidence: 99%

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Molecular Signatures of the Insulin-Like Growth Factor 1-Mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers

Cevenini

Orrú

Mancini

et al. 2018

IJMS

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The insulin-like growth factor (IGF) system, which is constituted by the IGF-1 and IGF-2 peptide hormones, their corresponding receptors and several IGF binding proteins, is involved in physiological and pathophysiological processes. The IGF system promotes cancer proliferation/survival and its signaling induces the epithelial-mesenchymal transition (EMT) phenotype, which contributes to the migration, invasiveness, and metastasis of epithelial tumors. These cancers share two major IGF-1R signaling transduction pathways, PI3K/AKT and RAS/MEK/ERK. However, as far as we could review at this time, each type of cancer cell undergoes EMT through tumor-specific routes. Here, we review the tumor-specific molecular signatures of IGF-1-mediated EMT in breast, lung, and gastric cancers.

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Section: Igf-1 Signaling and Emt Activation In Breast Lung And Gmentioning

confidence: 92%

Section: The Igf Systemmentioning

confidence: 99%

Section: Igf-1 Signaling and Emt Activation In Breast Lung And Gmentioning

confidence: 99%

Section: Igf-1 Signaling and Emt Activation In Breast Lung And Gmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Signatures of the Insulin-Like Growth Factor 1-Mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers

Cevenini

Orrú

Mancini

et al. 2018

IJMS

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“…Recent investigations have stressed the role of circulating growth factors, prohormones, and sexual hormones, which are able to stimulate cancer cell proliferation through the activation of their respective receptors [19,20]. In particular, the phosphoinositide 3-kinase-AKT-mammalian target of rapamycin (PI3K-AKT-mTOR) pathway is a frequently hyperactivated pathway in cancer and is important for tumor cell growth and survival.…”

Section: Molecular and Systemic Effects Linking Exercise To Cancer Prmentioning

confidence: 99%

The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Physical Activity and Sedentary Behavior

Barbieri

Falcieri

Santi

et al. 2018

JFMK

Self Cite

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Abstract:We are glad to introduce the sixth Journal Club. This edition is focused on several relevant studies published in the last years in the field of physical activity and sedentary behavior, chosen by our Editorial Board members and their colleagues. We hope to stimulate your curiosity in this field and to share with you the passion for the sport seen also from the scientific point of view. The Editorial Board members wish you an inspiring lecture.

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Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle

Vassilakos

Barton

2018

Comprehensive Physiology

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The insulin‐like growth factor (IGF) pathway is essential for promoting growth and survival of virtually all tissues. It bears high homology to its related protein insulin, and as such, there is an interplay between these molecules with regard to their anabolic and metabolic functions. Skeletal muscle produces a significant proportion of IGF‐1, and is highly responsive to its actions, including increased muscle mass and improved regenerative capacity. In this overview, the regulation of IGF‐1 production, stability, and activity in skeletal muscle will be described. Second, the physiological significance of the forms of IGF‐1 produced will be discussed. Last, the interaction of IGF‐1 with other pathways will be addressed. © 2019 American Physiological Society. Compr Physiol 9:413‐438, 2019.

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Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor

Abstract: Our data indicate that IGF1 pro-forms can induce breast cancer cell proliferation via the IGF1R, independent from the mature IGF1 form. These results underline the importance of an accurate assessment of the presence of IGF1 pro-forms within the breast cancer microenvironment.

Cited by 36 publications

References 30 publications

Molecular Signatures of the Insulin-Like Growth Factor 1-Mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers

Molecular Signatures of the Insulin-Like Growth Factor 1-Mediated Epithelial-Mesenchymal Transition in Breast, Lung and Gastric Cancers

The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Physical Activity and Sedentary Behavior

Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle

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