Human Illness Associated with Use of Veterinary Vaccines

Strausbaugh, Larry J.; Berkelman, Ruth L.

doi:10.1086/375595

Cited by 105 publications

(24 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are documented cases showing the pathogenic nature of strains Rev. 1 and S19 in humans [14]. Thus, for the effective monitoring of both brucellosis control programs and human disease it is important to have reliable tests to differentiate vaccine and field strains.…”

Section: Introductionmentioning

confidence: 99%

MLVA Genotyping of Brucella melitensis and Brucella abortus Isolates from Different Animal Species and Humans and Identification of Brucella suis Vaccine Strain S2 from Cattle in China

Jiang

Wang

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

In China, brucellosis is an endemic disease and the main sources of brucellosis in animals and humans are infected sheep, cattle and swine. Brucella melitensis (biovars 1 and 3) is the predominant species, associated with sporadic cases and outbreak in humans. Isolates of B. abortus, primarily biovars 1 and 3, and B. suis biovars 1 and 3 are also associated with sporadic human brucellosis. In this study, the genetic profiles of B. melitensis and B. abortus isolates from humans and animals were analyzed and compared by multi-locus variable-number tandem-repeat analysis (MLVA). Among the B. melitensis isolates, the majority (74/82) belonged to MLVA8 genotype 42, clustering in the ‘East Mediterranean’ group. Two B. melitensis biovar 1 genotype 47 isolates, belonging to the ‘Americas’ group, were recovered; both were from the Himalayan blue sheep (Pseudois nayaur, a wild animal). The majority of B. abortus isolates (51/70) were biovar 3, genotype 36. Ten B. suis biovar 1 field isolates, including seven outbreak isolates recovered from a cattle farm in Inner Mongolia, were genetically indistinguishable from the vaccine strain S2, based on MLVA cluster analysis. MLVA analysis provided important information for epidemiological trace-back. To the best of our knowledge, this is the first report to associate Brucella cross-infection with the vaccine strain S2 based on molecular comparison of recovered isolates to the vaccine strain. MLVA typing could be an essential assay to improve brucellosis surveillance and control programs.

show abstract

Section: Introductionmentioning

confidence: 99%

MLVA Genotyping of Brucella melitensis and Brucella abortus Isolates from Different Animal Species and Humans and Identification of Brucella suis Vaccine Strain S2 from Cattle in China

Jiang

Wang

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Commercially available vaccine strains used for brucellosis eradication in cattle have been tested in wildlife species (Davis and Elzer, 2002), but results from elk vaccination trials have shown that efficacy is reduced in comparison to cattle. Additional vaccination-related problems include interference with diagnosis (Schurig et al, 2002), resistance to antibiotics, and potential virulence for animals and humans (Berkelman, 2003; Ashford et al, 2004). The B. abortus strain 19 (S19) appeared to be safe in adult elk but has been shown to reduce abortion rates only by 30% (Thorne et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Immune Response of Red Deer (Cervus Elaphus) to Live Rb51 Vaccine Strain Using Composite Microspheres

Arenas-Gamboa

Ficht

Davis

et al. 2009

Journal of Wildlife Diseases

View full text Add to dashboard Cite

Brucellosis is an important zoonotic disease of nearly worldwide distribution. The occurrence of the infection in humans is largely dependent on the prevalence of brucellosis in animal reservoirs, including wildlife. The current vaccine used for cattle Brucella abortus strain RB51, has proven ineffective in protecting bison (Bison bison) and elk (Cervus nelsoni) from infection and abortion. To test possible improvements in vaccine efficacy, a novel approach of immunization was examined from April 2004 to November 2006 using alginate composite microspheres containing a nonimmunogenic, eggshell-precursor protein of the parasite Fasciola hepatica (Vitelline protein B, VpB) to deliver live vaccine strain RB51. Red deer (Cervus elaphus), used as a model for elk, were vaccinated orally (PO) or subcutaneously (SC) with 1.5×1010 viable organisms per animal. Humoral responses postvaccination (immunoglobulin G [IgG] levels), assessed at different time points, indicated that capsules containing live RB51 elicited an anti-Brucella specific IgG response. Furthermore, the encapsulated vaccine elicited a cell-mediated response that the nonencapsulated vaccinates failed to produce. Finally, red deer were challenged with B. abortus strain 19 by conjunctival exposure. Only animals that received encapsulated RB51 vaccine by either route exhibited a significant reduction in bacterial counts in their spleens. These data suggest that alginate-VpB microspheres provide a method to enhance the RB51 vaccine performance in elk.

show abstract

“…No additional details are available about this patient but an avian source of exposure seems plausible. A number of reports provide evidence to suggest that many human infections are the result of contact with infected or vaccinated pets (Gueirard et al 1995;Dworkin et al 1999;Foley et al 2002;Berkelman 2003;Rath et al 2008;Register et al 2012;Brady et al 2014;Garcia-de-la-Fuente et al 2015). An example of typing data in support of this concept, acquired here and from a prior study (Register et al 2012), is the finding that of 14 B. bronchiseptica isolates known to be ST27/RT4, six were cultured from humans, seven from dogs or cats and one from a pig.…”

Section: Discussionmentioning

confidence: 99%

Comparison of ribotyping and sequence-based typing for discriminating among isolates of Bordetella bronchiseptica

Nicholson

Brunelle

2016

Journal of Microbiological Methods

View full text Add to dashboard Cite

PvuII ribotyping and MLST are each highly discriminatory methods for genotyping Bordetella bronchiseptica, but a direct comparison between these approaches has not been undertaken. The goal of this study was to directly compare the discriminatory power of PvuII ribotyping and MLST, using a single set of geographically and genetically diverse strains, and to determine whether subtyping based on repeat region sequences of the pertactin gene (prn) provides additional resolution. One hundred twenty-two isolates were analyzed, representing 11 mammalian or avian hosts, sourced from the United States, Europe, Israel and Australia. Thirty-two ribotype patterns were identified; one isolate could not be typed. In comparison, all isolates were typeable by MLST and a total of 30 sequence types was identified. An analysis based on Simpson's Index of Diversity (SID) revealed that ribotyping and MLST are nearly equally discriminatory, with SIDs of 0.920 for ribotyping and 0.919 for MLST. Nonetheless, for ten ribotypes and eight MLST sequence types, the alternative method discriminates among isolates that otherwise type identically. Pairing prn repeat region typing with ribotyping yielded 54 genotypes and increased the SID to 0.954. Repeat region typing combined with MLST resulted in 47 genotypes and an SID of 0.944. Given the technical and practical advantages of MLST over ribotyping, and the nominal difference in their SIDs, we conclude MLST is the preferred primary typing tool. We recommend the combination of MLST and prn repeat region typing as a high-resolution, objective and standardized approach valuable for investigating the population structure and epidemiology of B. bronchiseptica.

show abstract

Human Illness Associated with Use of Veterinary Vaccines

Cited by 105 publications

References 25 publications

MLVA Genotyping of Brucella melitensis and Brucella abortus Isolates from Different Animal Species and Humans and Identification of Brucella suis Vaccine Strain S2 from Cattle in China

MLVA Genotyping of Brucella melitensis and Brucella abortus Isolates from Different Animal Species and Humans and Identification of Brucella suis Vaccine Strain S2 from Cattle in China

Enhanced Immune Response of Red Deer (Cervus Elaphus) to Live Rb51 Vaccine Strain Using Composite Microspheres

Comparison of ribotyping and sequence-based typing for discriminating among isolates of Bordetella bronchiseptica

Contact Info

Product

Resources

About