Human immunodeficiency virus infection in voluntary blood donors in North-Eastern Nigeria

Olokoba,; Tidi,; Salawu,; Danburam,; Desalu,

doi:10.5251/ajsir.2010.1.3.435.438

Cited by 19 publications

(21 citation statements)

References 10 publications

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“…this is much higher than a similar study done at Lagos, which recorded 4.7% 2 our results were much higher than a report of a similar study done at Yola, Nigeria 2.4% 11 . Some previous reports were higher than ours for instance, a study done at Ibadan Nigeria by Fashola et al 12 reported a prevalence rate of 13.2%, another study done in the South-south region of Nigeria reported 10.6%…”

Section: Tti Neg 82%contrasting

confidence: 56%

Seroprevalence of transfusion transmissible infections (TTI), in first time blood donors in Abeokuta, Nigeria.

Motayo¹,

Faneye²,

Udo³

et al. 2015

Afr H. Sci.

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Background: Transfusion transmissible infections, such as HIV, HBV, HCV and syphilis are on the rise and pose a threat to blood safety. Objective: To determine prevalence and demographic profiles of TTI's among first time blood donors in Abeokuta, Nigeria. Methods: The study was conducted between February to November 2013; 130 first time blood donors were tested for the presence of HIV, HBsAg, HCV antibodies and Treponema palidium antibodies using EIA based rapid immunochromatographic kits. Data analysis was done using SPSS with a level of significance of p<0.05. Results: Prevalence rates to HIV, HBsAg, HCV antibody, were 6.2% (n=8), 10% (n=13) and 1.5% (n=2), there was 0% prevalence to Treponema palidium antibodies. Group specific prevalence rates revealed that educational status was associated with HBsAg positivity (p = 0.028), donors with a history of previous blood transfusion was also statistically associated with HIV sero-reactivity (p = 0.013). Conclusions: High levels of HBsAg and HIV were observed, there is need to revise the donor testing algorithm in Nigeria in line with the prevalence of TTI's. We also advocate that a National surveillance system for TTI's be established through our National blood transfusion service (NBTS) program, a second serological test is also suggested to reduce the risk of occult HBV infection in Nigeria.

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Section: Tti Neg 82%contrasting

confidence: 56%

Seroprevalence of transfusion transmissible infections (TTI), in first time blood donors in Abeokuta, Nigeria.

Motayo¹,

Faneye²,

Udo³

et al. 2015

Afr H. Sci.

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“…A number of them have suggested that increasing age is a higher risk to have the disease, probably due to longer exposure to multiple risk factors, [12][13][14] and higher in males than females. 15,16 Although, the sample size is not very large as compared to the report in earlier studies stated, but the results obtained are very important since this is the first study from Calabar, Nigeria, where a high frequency rate has been seen in ELISA method when compared to rapid strip test device. So, there is a great and urgent need for people in this locality and beyond to screen their blood for HBV and it should be screened using the ELISA technique which has been found to be more sensitive and accurate as compared to the rapid test strip device method.…”

Section: Discussionmentioning

confidence: 67%

“…14,15 Following Blumberg's discovery of hepatitis B surface antigen (HBsAg), many attempts have been made to develop several in vitro diagnostic techniques for the detection of this antigen and its homologous antibody, including a wide-range of different serological, immunological and molecular-biological techniques. 16 According to the financial facilities as well as technical feasibility (i.e. trained personnel and the availability of advanced laboratory equipment) one should have the choice to select and apply one or more of these laboratory tests.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity comparison between rapid one-step test strip and ELISA methods in detection of HBsAg among selected chronic liver disease patients in University of Calabar Teaching hospital, Calabar, Nigeria

et al. 2015

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Background: Hepatitis B virus (HBV) is the eloquent hepatic infection that leads to hepatocellular carcinoma. This study aims to determine the frequency of HBV by screening selected chronic liver disease (CLD) patients alongside few apparently healthy subjects who might be carriers and pose a high risk in HBV transmission. This study also aims to compare the sensitivity between two diagnostic tests; one step rapid test strip device and Enzyme Linked Immunosorbent Assay (ELISA).Methodology: Serum of 111 subjects comprising of 76 CLD patients and 35 apparently healthy (control) subjects was screened for Hepatitis B surface Antigen (HBsAg).Results: Sero-positivity of the two methods of detecting HBsAg was higher in age group 26-35 years and the male folk was found higher in number than the females. The seropositivity of HBV was 28.8% and 81.1% while seronegativity was 71.2% and 18.9% for rapid test strip test device and ELISA test methods, respectively. All the CLD patients 76(100%) and 14 out of 35 of the apparently healthy subjects was positive for ELISA test method.Conclusion: In conclusion, comparing the two methods, ELISA test is more sensitive than one step rapid test strip device for detecting HBsAg in University of Calabar Teaching Hospital, Nigeria.Therefore, we recommend strongly, thatELISA method be used to confi rm test results obtained from the one step rapid test strip,when screen for CLD.DOI: http://dx.doi.org/10.3126/ajms.v6i5.11851 Asian Journal of Medical Sciences Vol.6(5) 2015 56-60

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“…Our study noted no correlation between HIV and other infections. A strict selection criteria for blood donors to exclude those with multiple sexual partners is recommended, and all the affected donors should be treated appropriately [35].…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Transfusion Transmitted Infections Among Apparently Healthy Blood Donors in Blood Bank RIMS Ranchi From 2008 to 2014

Kumari

Kumar

Srivastava

2016

OSJ

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Context:Apparently healthy blood donors might carry out transfusion transmitted infections which might be fatal for the donor himself as well as the recipient later on. Aim: To assess the seroprevalence of transfusion-transmitted infections (TTI) among apparently healthy blood donors in Ranchi, India. Methods and Materials: All blood samples were screened for HIV-I and II, HBsAg, HCV (by using third generation enzymelinked immunoadsorbent assay technique), Syphilis (by Rapid Plasma Reagin Kit), and Malaria antigen both for plasmodium falciparum and plasmodium vivax (by One step, rapid, immunochromatographic test). Result: On screening of 106,306 blood units for TTIs, 1,462 (1.37 %) donors were found positive for one of the TTIs. Highest prevalence was for HBV (970 donors -0.91%) ranging from 0.73% to 1.19%. This was followed by Malaria (272 donors -0.25%) ranging from 0.08% to 0.48%, HCV (127 donors -0.11%) ranging from 0.04% to 0.25%, HIV (72 donors -0.06%) ranging from 0.03% to 0.10%, and syphilis (21 donors 0.01%) ranging from 0.00% to 0.09%. Conclusions: Apparently healthy blood donors are not omitted from the danger of transfusion-transmitted infection.

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Human immunodeficiency virus infection in voluntary blood donors in North-Eastern Nigeria

Cited by 19 publications

References 10 publications

Seroprevalence of transfusion transmissible infections (TTI), in first time blood donors in Abeokuta, Nigeria.

Seroprevalence of transfusion transmissible infections (TTI), in first time blood donors in Abeokuta, Nigeria.

Sensitivity comparison between rapid one-step test strip and ELISA methods in detection of HBsAg among selected chronic liver disease patients in University of Calabar Teaching hospital, Calabar, Nigeria

Spectrum of Transfusion Transmitted Infections Among Apparently Healthy Blood Donors in Blood Bank RIMS Ranchi From 2008 to 2014

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