Human Immunodeficiency Virus Preexposure Prophylaxis for Adolescent Men

Arrington‐Sanders, Renata

doi:10.1001/jamapediatrics.2017.2397

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…4 Additionally, less than 7% of PrEP prescriptions have gone to men under 25. 5 To better understand the slow rate of PrEP uptake, several recent studies assessed whether participants were aware of PrEP and whether they had ever used PrEP in their lifetime. 6–8 Data also indicate differences in PrEP awareness and usage patterns across various groups, including lower rates of each among Black and transgender individuals.…”

Section: Introductionmentioning

confidence: 99%

Threefold Increase in PrEP Uptake Over Time with High Adherence Among Young Men Who Have Sex With Men in Chicago

et al. 2018

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The goal of this work is to better understand utilization and uptake of pre-exposure prophylaxis (PrEP) among young men who have sex with men (YMSM) and transgender women (TGW). We assessed trends and correlates of PrEP use and adherence across three time points of longitudinal data collection among 885 YMSM and TGW (aged 16-29) from the RADAR cohort in Chicago, 2015-2017. Past 6-month PrEP use increased across three visits: from 6.6 to 17.5%. In multivariable models, past 6-month PrEP use was significantly associated with participation in condomless sex, having more sexual partners, and older age. At least three-quarters of current PrEP users reported being ≥ 90% adherent to PrEP medication across all visits. Past 6-month PrEP use increased over time with those who participated in high-risk HIV behaviors also those most likely to have taken PrEP. As PrEP uptake continues to rise, more research will be needed to understand predictors of PrEP usage, as well as patterns of sexual behavior change following uptake.

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Section: Introductionmentioning

confidence: 99%

Threefold Increase in PrEP Uptake Over Time with High Adherence Among Young Men Who Have Sex With Men in Chicago

et al. 2018

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“…Older participants were 1.97 times more likely to have protective levels than younger participants. At week 24, older participants (ages 19-22) were 2.4 times more likely than younger participants (ages [15][16][17][18] to have protective levels. Perception of risk also approached significance at 12 and 24 weeks with participants who reported missing their medication because they were not having risky sex 91.6 and 92 percent (OR, 95% CI, p-value 0.022; OR, 95% CI, p-value 0.016, respectively) being less likely than participants who did not report this reason to have protective TFV-DP levels.…”

Section: Resultsmentioning

confidence: 99%

“…Some have suggested that younger adolescents will require not only additional visits than what is currently recommended by national guidelines, but also team members that can address these needs and help youth incorporate PrEP into their daily lives. 17 The ability to develop abstract thinking, plan for one's future, and integrate a positive adult identity, while simultaneously managing potential disapproval of same-sex behavior, and daily medications for HIV prevention, is likely to require an interdisciplinary developmentally-centered approach needed to support optimal adherence.…”

Section: Discussionmentioning

confidence: 99%

Brief Report: Role of Sociobehavioral Factors in Subprotective TFV-DP Levels Among YMSM Enrolled in 2 PrEP Trials

Arrington‐Sanders

Wilson

Perumean-Chaney

et al. 2019

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background-Young men who have sex with men (YMSM) experience disparities in HIV acquisition more than any other group. Daily oral pre-exposure prophylaxis (PrEP) with tenofovir/ embricitabine (TDF/FTC) has been shown to effectively prevent HIV transmission in YMSM; however, recent studies suggest that young Black men who have sex with men (YBMSM) experience sub-protective levels of tenofovir diphosphate (TFV-DP) more frequently than other groups. Setting-Combined data from Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) 110/113, two open label PrEP studies that provided PrEP and evidence-based behavioral interventions to young MSM (YMSM) age 15 to 22 years old.

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“…90,91 The 2018 Food and Drug Administration approval for use of pre-exposure prophylaxis among adolescents at risk for HIV acquisition 92 will hopefully spur additional research on implementation for SGM youth, which has specific challenges related to parental consent, confidentiality, and health privacy. [93][94][95] More broadly, there is a need for a shift from such models of health disparity, where health imbalances and antecedent risk and protective factors are identified, to health equity and the identification of interventions to successfully overcome these disparities. The former studies require population-based epidemiologic and developmentally based cross-sectional or longitudinal designs, whereas the latter require rigorous intervention trials.…”

Section: Methodsmentioning

confidence: 99%

Methodological Considerations for Advancing Research on the Health and Wellbeing of Sexual and Gender Minority Youth

et al. 2019

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Continued research with sexual and gender minority (SGM) youth is essential both to understand health disparities and to develop interventions targeting those disparities, but conducting rigorous, ethical research with these populations remains a substantial challenge. In addition to considerations for research with adolescents in general, such as utilizing developmentally appropriate measures and obtaining parental permission, factors unique to SGM youth must be addressed at every step of the research process. Defining the study population is complex, as is recruiting a sample once it is defined. Measurement is another challenge, given the paucity of measures developed for or validated with SGM samples. Key constructs, such as sexual orientation, gender identity, and family acceptance, are not amenable to randomization and involving minor participants' parents poses ethical concerns given the precarious home and safety situations that can arise from employing typical study procedures with youth who have a stigmatized identity. In this article, we examine some of these unique methodological challenges. Informed by theoretical and empirical literature, practical experience, and an ongoing dialogue with SGM youth themselves, we present a guide to best practices for ethical, productive research with SGM youth. By discussing existing approaches to studying SGM youth and suggesting innovative ways to approach the questions that remain, we hope to assist the research community in addressing methodological gaps to advance research on SGM youth in relation to families and schools.

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Human Immunodeficiency Virus Preexposure Prophylaxis for Adolescent Men

Cited by 10 publications

References 13 publications

Threefold Increase in PrEP Uptake Over Time with High Adherence Among Young Men Who Have Sex With Men in Chicago

Threefold Increase in PrEP Uptake Over Time with High Adherence Among Young Men Who Have Sex With Men in Chicago

Brief Report: Role of Sociobehavioral Factors in Subprotective TFV-DP Levels Among YMSM Enrolled in 2 PrEP Trials

Methodological Considerations for Advancing Research on the Health and Wellbeing of Sexual and Gender Minority Youth

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