Human immunodeficiency virus type 1 infection of human CD4-transgenic rabbits

Dunn, C.S.; Mehtali, Majid; Houdebine, L. M.; Gut, Jean‐Pierre; Kirn, A.; Aubertin, A.-M.

doi:10.1099/0022-1317-76-6-1327

Cited by 44 publications

(32 citation statements)

References 50 publications

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“…(Fig. 6A), much higher than those reported for rodent and rabbit cells (8,16,32). Furthermore, virus particles produced by infected mink cells are as infectious as those obtained from human cells (Fig.…”

Section: Discussioncontrasting

confidence: 43%

“…However, due to the presence of multiple blocks to HIV infection and replication in cells of this species, it is far from clear that a robust rodent model for AIDS can be developed. Rabbits have a long history of serving as useful experimental models, especially for studies of humoral immune responses, but HIV replication efficiency and reproducibility are poor in rabbits (8,9,32,35). Thus, there is a need to continue the search for novel animal model systems for the study of HIV disease.…”

Section: Discussionmentioning

confidence: 99%

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Susceptibility of Mink ( Mustera vision )-Derived Cells to Replication by Human Immunodeficiency Virus Type 1

Koito

Kameyama

Cheng‐Mayer

et al. 2003

J Virol

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In vivo studies for understanding viral transmission and replication, host immune responses, and pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection would greatly benefit from the establishment of a small-animal model. In this study, we explored the potential of American mink (Mustera vison) as a susceptible host. We found that primary cells and cell lines derived from this species efficiently supported trans-activation of the HIV-1 long terminal repeat by Tat. Accordingly, the cysteine residue at position 261, which has been shown to be important for interaction of the human cyclin T1 with the HIV-1 regulatory protein Tat

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Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Susceptibility of Mink ( Mustera vision )-Derived Cells to Replication by Human Immunodeficiency Virus Type 1

Koito

Kameyama

Cheng‐Mayer

et al. 2003

J Virol

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show abstract

“…Although the targeted expression of the apo B-editing protein in the liver of the transgenic rabbits resulted in reduced LDL and lipoprotein(a) concentrations as intended, many of the animals developed liver dysplasia, suggesting that high level expression of the editing protein had unforeseen and detrimental side effects, possibly via the editing of other important mRNAs. The rabbit has also been used in HIV-1 research, with the development of a line expressing the human CD4 protein on T lymphocytes (22). Susceptibility to HIV infection was demonstrated, and although the rabbits are less sensitive to infection than humans, they may represent an inexpensive alternative to primates for many studies.…”

Section: Nonmurine Species In Biomedical Researchmentioning

confidence: 99%

Transgenesis in the rat and larger mammals.

Mullins¹,

Mullins²

1996

J. Clin. Invest.

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“…The laboratory rabbit appears to be susceptible to HIV, but requires large inocula and viral replication does not spread (Dunn et al, 1995;Filice, Cereda, and Varnier, 1988). Rabbit cell lines expressing hCD4 and hCCR5 demonstrated an increase in infection and replication of CCR5 dependent strain of HIV (JR-CSF and YU-2) (Speck et al, 1998).…”

Section: Wwwintechopencommentioning

confidence: 99%