Human infection with avian influenza A H6N1 virus: an epidemiological analysis

Wei, Sung-Hsi; Yang, Ji-Rong; Wu, Ho-Sheng; Chang, Ming-Chuan; Lin, Jen-Shiou; Lin, Chia-Cheng; Liu, Yu-Lun; Lo, Yi‐Chun; Yang, Chin-Hui; Chuang, Jen-Hsiang; Lin, Min-Cheng; Chung, Wen-Chen; Liao, Chia-Hung; Lee, Min-Shiuh; Huang, Wan‐Ting; Chen, Pei‐Jung; Liu, Ming‐Tsan; Chang, Feng–Yee

doi:10.1016/s2213-2600(13)70221-2

Cited by 186 publications

(167 citation statements)

References 29 publications

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“…During the past two decades many novel AIVs infecting poultry have emerged in China, including those that cause human disease (Claas et al, 1998;Butt et al, 2005;Gao et al, 2013;Guan & Smith, 2013;Wei et al, 2013;Chen et al, 2014;Su et al, 2015;Yang et al, 2015). Interestingly, almost all of these human-infecting AIVs are prevalent in live poultry markets (LPMs) in southern China, a locality often regarded as an 'epicenter' of influenza genetic diversity and emergence (Guan & Smith, 2013).…”

Section: Introductionmentioning

confidence: 99%

Diversity and evolution of avian influenza viruses in live poultry markets, free-range poultry and wild wetland birds in China

Chen

Lin

Guo

et al. 2016

Journal of General Virology

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The wide circulation of novel avian influenza viruses (AIVs) highlights the risk of pandemic influenza emergence in China. To investigate the prevalence and genetic diversity of AIVs in different ecological contexts, we surveyed AIVs in live poultry markets (LPMs), free-range poultry and the wetland habitats of wild birds in Zhejiang and Hubei provinces. Notably, LPMs contained the highest frequency of AIV infection, and the greatest number of subtypes (n59) and subtype co-infections (n514), as well as frequent reassortment, suggesting that they play an active role in fuelling AIV transmission. AIV-positive samples were also identified in wild birds in both provinces and free-range poultry in one sampling site close to a wetland region in Hubei. H9N2, H7N9 and H5N1 were the most commonly sampled subtypes in the LPMs from Zhejiang, whilst H5N6 and H9N2 were the dominant subtypes in the LPMs from Hubei. Phylogenetic analyses of the whole-genome sequences of 43 AIVs revealed that three reassortant H5 subtypes were circulating in LMPs in both geographical regions. Notably, the viruses sampled from the wetland regions and free-range poultry contained complex reassortants, for which the origins of some segments were unclear. Overall, our study highlights the extent of AIV genetic diversity in two highly populated parts of central and south-eastern China, particularly in LPMs, and emphasizes the need for continual surveillance.

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Section: Introductionmentioning

confidence: 99%

Diversity and evolution of avian influenza viruses in live poultry markets, free-range poultry and wild wetland birds in China

Chen

Lin

Guo

et al. 2016

Journal of General Virology

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“…I nfluenza A virus is a major threat to public health-causing seasonal flu and occasional pandemics-with extensive attention paid to the recently identified human-infecting avian influenza A viruses [1][2][3][4] . Different subtypes of avian influenza A viruses have caused sporadic human infections in the past, including H5N1, H6N1, H7N9 and H9N2 (refs 1,2,5-10).…”

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confidence: 99%

Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus

Wang

Zhang

et al. 2015

Nat Commun

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Since December 2013, at least three cases of human infections with H10N8 avian influenza virus have been reported in China, two of them being fatal. To investigate the epidemic potential of H10N8 viruses, we examined the receptor binding property of the first human isolate, A/Jiangxi-Donghu/346/2013 (JD-H10N8), and determined the structures of its haemagglutinin (HA) in complex with both avian and human receptor analogues. Our results suggest that JD-H10N8 preferentially binds the avian receptor and that residue R137-localized within the receptor-binding site of HA-plays a key role in this preferential binding. Compared with the H7N9 avian influenza viruses, JD-H10N8 did not exhibit the enhanced binding to human receptors observed with the prevalent H7N9 virus isolate Anhui-1, but resembled the receptor binding activity of the early-outbreak H7N9 isolate (Shanghai-1). We conclude that the H10N8 virus is a typical avian influenza virus.

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“…For viral challenge, anesthetized mice were infected intranasally (i.n.) with 5 Charles River, Wilmington, MA) or Cal07 (Pandemrix; 1:50; GlaxoSmithKline, Brentford, U.K.). The coated plates were blocked, and serial dilutions of mouse sera were added to the ELISA plates.…”

Section: Vaccination and Viral Challengementioning

confidence: 99%

“…The major causes of influenzarelated morbidity and mortality in humans have been the H1, H2, and H3 subtypes of influenza A, as illustrated by the three pandemics of the twentieth century: the 1918 Spanish flu (H1), the 1957 Asian flu (H2), and the 1968 Hong Kong flu (H3). However, recently emerging subtypes of traditionally zoonotic (primarily avian) strains, such as H5, H6, H7, H9, and H10 influenza viruses, have caused severe, but isolated, disease outbreaks in humans (1)(2)(3)(4)(5) and may cause future influenza pandemics. Because current vaccines predominantly induce strain-specific Abs (6, 7) and require a substantial amount of time for production (8)(9)(10), novel vaccine strategies conferring broader protection are needed.…”

mentioning

confidence: 99%

Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza

Anderson

Baranowska-Hustad

Braathen

et al. 2018

The Journal of Immunology

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There is a need for vaccines that can confer broad immunity against highly diverse pathogens, such as influenza. The efficacy of conventional influenza vaccines is dependent on accurate matching of vaccines to circulating strains, but slow and limited production capacities increase the probability of vaccine mismatches. In contrast, DNA vaccination allows for rapid production of vaccines encoding novel influenza Ags. The efficacy of DNA vaccination is greatly improved if the DNA-encoded vaccine proteins target APCs. In this study, we have used hemagglutinin (HA) genes from each of six group 1 influenza viruses (H5, H6, H8, H9, H11, and H13), and inserted these into a DNA vaccine format that induces delivery of the HA protein Ags to MHC class II molecules on APCs. Each of the targeted DNA vaccines induced high titers of strain-specific anti-HA Abs. Importantly, when the six HA vaccines were mixed and injected simultaneously, the strain-specific Ab titers were maintained. In addition, the vaccine mixture induced Abs that cross-reacted with strains not included in the vaccine mixture (H1) and could protect mice against a heterosubtypic challenge with the H1 viruses A/Puerto Rico/8/1934 (H1N1) and A/California/07/2009 (H1N1). The data suggest that vaccination with a mixture of HAs could be useful for induction of strain-specific immunity against strains represented in the mixture and, in addition, confer some degree of cross-protection against unrelated influenza strains.

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Human infection with avian influenza A H6N1 virus: an epidemiological analysis

Abstract: Taiwan Centres for Disease Control.

Cited by 186 publications

References 29 publications

Diversity and evolution of avian influenza viruses in live poultry markets, free-range poultry and wild wetland birds in China

Diversity and evolution of avian influenza viruses in live poultry markets, free-range poultry and wild wetland birds in China

Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus

Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza

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