Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction

Abstract

Ebert EC, Panja A, Praveen R. Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction.

Self-renewal molecular mechanisms of colorectal cancer stem cells

“…Colon cancer HT-29 and Caco-2 cells express CD58 at low levels (99). CD58 is a ligand for CD2 and their interaction functions as a specific immunity co-stimulation to promote T cells to secrete CXCL-8, which can promote the self-renewal of CCSCs (100). Our research demonstrated that CD58 promotes the maintenance of self-renewal through activating the Wnt/β-catenin pathway (20).…”

Gene profile analysis of CD8+ ILT3-Fc induced T suppressor cells

“…CD2 functions as an adhesion molecule in the interaction between T cells and APC, whose engagement induces costimulatory (CD40, CD80, CD86), adhesion (CD54, CD58), and homing (CCR7) molecules on APC [28] and augments the IL-8 response from intestinal TCR␣␤ ϩ CD8 T cells [29]. Similar to CD2, LAG3 also can induce the maturation of dendritic cells.…”

Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus

“…The observations at CD58, CYP27B1, IL7R, and IRF8 in human monocytes confirm earlier work relating expression of these genes to TNF-a stimulation in different experimental systems. [26][27][28][29] Moreover, assessing the genotypic effect of rs1800693 on the expression of these MS genes, we find a greater number of suggestive effects (p , 0.05) following TNF-a stimulation when compared to baseline (table 2). For example, CD40 gene expression is enhanced following TNF-a stimulation in rs1800693 GG subjects relative to rs1800693 AA subjects (p 5 0.007).…”