Human isolates of Salmonella enterica serovar Typhimurium from Taiwan displayed significantly higher levels of antimicrobial resistance than those from Denmark

Torpdahl, Mia; Lauderdale, Tsai‐Ling; Liang, Shiu-Yun; Li, Ishien; Wei, Sung-Hsi; Chiou, Chien-Shun

doi:10.1016/j.ijfoodmicro.2012.11.022

Cited by 23 publications

(20 citation statements)

References 33 publications

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“…S. typhimurium is among the major zoonotic pathogens with a high occurrence of antibacterial resistance (12). This invasive serotype poses health hazard to human by eating different contaminated raw meat and poultry products (13).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance Pattern and Biofilm Formation Ability of Clinically Isolates of Salmonella enterica Serotype typhimurium

Ghasemmahdi¹,

Tajik²,

Moradi³

et al. 2015

Int J Enteric Pathog

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Background:The emergence of antimicrobial-resistant bacteria with biofilm formation ability may be a major threat to public health and food safety and sanitation. Objectives: The aim of this study was to determine antibiotic resistance patterns and biofilm production characteristics of Salmonella typhimurium isolated from different species of birds. Materials and Methods:The antibiotic resistance patterns of 38 pre-identified isolates were screened by standard Kirby-Bauer discdiffusion method performed on Mueller-Hinton agar to a panel of 17 antibiotics. The extent of biofilm formation was measured by Microtiter plate (MTP)-based systems. Results: The highest antimicrobial resistance was detected against nalidixic acid (97%), followed by doxycycline (86%), colistin (84%), streptomycin (84%) and tetracycline (84%). All isolates were sensitive to amikacin (100%) and 97% and 95% of the isolates were sensitive to ceftazidime and ceftriaxone, respectively. Twenty one different antibiotic resistance patterns were observed among S. typhimurium isolates. According to the results of the microtitre plate biofilm assay, there was a wide variation in biofilm forming ability among S. typhimurium isolates. Most of the isolates (60.52%) were not capable of producing biofilm, while 26.31%, 7.89%, and 5.26% isolates were weak, strong and moderate biofilm producers, respectively. Conclusions: It was concluded that nearly all S. typhimurium isolates revealed a high multiple antibiotic resistant with low biofilm forming capabilities which proposed low association between biofilm formation and antibiotic resistance of a major food important pathogen.

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Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance Pattern and Biofilm Formation Ability of Clinically Isolates of Salmonella enterica Serotype typhimurium

Ghasemmahdi¹,

Tajik²,

Moradi³

et al. 2015

Int J Enteric Pathog

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“…In Asia, multiple epidemiological studies have addressed the characteristics of Salmonella Typhimurium in Thailand, Japan, Hongkong and Taiwan [7], [8], [9]. However, the incidence of Salmonella infections on the mainland of China has not been well documented.…”

Section: Introductionmentioning

confidence: 99%

The Molecular Epidemiological Characteristics and Genetic Diversity of Salmonella Typhimurium in Guangdong, China, 2007–2011

Sun

Huang

et al. 2014

PLoS ONE

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Background Salmonella enterica serovar Typhimurium is the most important serovar associated with human salmonellosis worldwide. Here we aimed to explore the molecular epidemiology and genetic characteristics of this serovar in Guangdong, China.MethodologyWe evaluated the molecular epidemiology and genetic characteristics of 294 endemic Salmonella Typhimurium clinical isolates which were collected from 1977 to 2011 in Guangdong, China, and compared them with a global set of isolates of this serovar using epidemiological data and Multilocus Sequence Typing (MLST) analysis.Principal FindingThe 294 isolates were assigned to 13 Sequencing types (STs) by MLST, of which ST34 and ST19 were the most common in Guangdong. All the STs were further assigned to two eBurst Groups, eBG1 and eBG138. The eBG1 was the major group endemic in Guangdong. Nucleotide and amino acid variability were comparable for all seven MLST loci. Tajima’s D test suggested positive selection in hisD and thrA genes (p<0.01), but positive selection was rejected for the five other genes (p>0.05). In addition, The Tajima’s D test within each eBG using the global set of isolates showed positive selection in eBG1 and eBG138 (p<0.05), but was rejected in eBG243 (p>0.05). We also analyzed the phylogenetic structure of Salmonella Typhimurium from worldwide sources and found that certain STs are geographically restricted. ACSSuT was the predominant multidrug resistance pattern for this serovar. The resistant profiles ACSSuTTmNaG, ACSSuTTmNa and ACSuTTmNaG seem to be specific for ST34, and ASSuTNa for ST19.ConclusionHere we presented a genotypic characterization of Salmonella Typhimurium isolates using MLST and found two major STs are endemic in Guangdong. Our analyses indicate that genetic selection may have shaped the Salmonella Typhimurium populations. However, further evaluation with additional isolates from various sources will be essential to reveal the scope of the epidemiological characteristics of Salmonella Typhimurium in Guangdong, China.

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“…Recently, an SGI conferring resistance to ASSuT was identified among strains of S. Typhimurium and its monophasic variant (20). This ASSuT-resistant clone soon became widespread in many European and Asia countries (27,28). SGI11 may be the first MDR genomic island identified in S. Typhi.…”

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confidence: 99%

Chromosome-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhi

Chiou

Alam

Kuo

et al. 2015

Antimicrob Agents Chemother

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Human isolates of Salmonella enterica serovar Typhimurium from Taiwan displayed significantly higher levels of antimicrobial resistance than those from Denmark

Cited by 23 publications

References 33 publications

Antibiotic Resistance Pattern and Biofilm Formation Ability of Clinically Isolates of Salmonella enterica Serotype typhimurium

Antibiotic Resistance Pattern and Biofilm Formation Ability of Clinically Isolates of Salmonella enterica Serotype typhimurium

The Molecular Epidemiological Characteristics and Genetic Diversity of Salmonella Typhimurium in Guangdong, China, 2007–2011

Chromosome-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhi

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