Human Leucocyte Antigen Class I Diversity among Human Immunodeficiency Virus Exposed Negative and Positive Children in Cameroon

Nkenfou, Céline Nguefeu; Nemes, Elisa; Mekue, Linda Mouafo; Grifoni, Alba; Dambaya, Béatrice; Ndukong, Elvis; Fainguem, Nadine; Cappelli, Giulia; Montesano, Carla; Colizzi, Vittorio; Amicosante, Massimo

doi:10.4172/2155-6113.1000439

Cited by 3 publications

(4 citation statements)

References 41 publications

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“…Controversial evidence was found for three out 16 alleles groups: HLA-B*58:02 allele was associated with rapid HIV progression in the study by Adland et al 10 ; however HLA-B *58:01 allele was associated with slower progression of HIV infection in children in the studies by Adland et al and Thobakgale et al 10 , 11 HLA-B*44 allele group was linked to lower risk of HIV infection by Nkenfou et al, 25 while Winchester et al detected a higher risk of HIV-1 MTCT in the presence of HLA-B*44:02 allele. 12 HLA-B*18 allele was associated with protection against early HIV-1 infection in the study by Farquhar, while 26 Adland detected association between HLA-B*18 and increased HIV-1 replication capacity.…”

Section: Resultsmentioning

confidence: 98%

“…Some associations between specific alleles and MTCT are not detected in distinct geographic regions, because HLA alleles profiles are different, and association between MTCT and HLA alleles could vary in different populations, as concluded by Zhang et al 32 For instance, Nkenfou et al detected association between expression of B*44 allelic group and resistance against HIV infection in Cameroonian children. 25 However, Winchester et al detected association between HLA-B*44:02 allelic and increased risk of MTCT in Afro-American and Hispanic mothers in Puerto Rico and United States. 12 …”

Section: Discussionmentioning

confidence: 98%

“… 38 The available data reinforce that HLA-B coincidence of mothers and children increases the risk of in uterus HIV infection, due to the reduced ability of children's immune system in recognizing HIV-1 through maternal immune response, which results in lower likelihood of alloimmune response. 24 , 25 , 38 , 39 …”

Section: Discussionmentioning

confidence: 99%

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A Systematic Review on the Influence of Hla-B Polymorphisms on Hiv-1 Mother-to-Child-Transmission

Angulo

Cuesta

Menezes

et al. 2019

The Brazilian Journal of Infectious Diseases

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

A Systematic Review on the Influence of Hla-B Polymorphisms on Hiv-1 Mother-to-Child-Transmission

Angulo

Cuesta

Menezes

et al. 2019

The Brazilian Journal of Infectious Diseases

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“… 43 , 44 HLA class 1 is the most studied between the two classes, mainly due to his implication in the mechanism of HIV-1 infection. HLA B*18 may protect breast-fed infants against both early and late HIV-1 acquisition in a Kenyan perinatal cohort, 25 also HLA-B*44 may be associated with the resistance to HIV infection upon mother to child exposure found in a Cameroonian children population, 26 as well a more specific genotype have shown that among infants the A*2/6802 super-type is associated with an estimated 7-fold protective effect from perinatal HIV-1 transmission. 27 In contrary HLA class 1 concordance between a mother and her infant and the homozygosity of the maternal HLA is associated with increased of overall risk, 24 while HLA discordance decreases the risk of MTCT.…”

Section: Hla Polymorphism Have An Impact On the Outcome Of Mtctmentioning

confidence: 99%

Host molecular factors and viral genotypes in the mother-to-child HIV-1 transmission in sub-Saharan Africa

Mouafo

Dambaya

Ngoufack

et al. 2017

J Public Health Afr

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Maternal viral load and immune status, timing and route of delivery, viral subtype, and host genetics are known to influence the transmission, acquisition and disease progression of human immunodeficiency virus-1 (HIV-1) infection. This review summarizes the findings from published works on host molecular factors and virus genotypes affecting mother to child transmission (MTCT) in Africa and identifies the gaps that need to be addressed in future research. Articles in PubMed, Google and AIDSearch and relevant conference abstracts publications were searched. Accessible articles on host factors and viral genetics impacting the MTCT of HIV, done on African populations till 2015 were downloaded. Forty-six articles were found and accessed; 70% described host genes impacting the transmission. The most studied gene was the CCR5 promoter, followed by the CCR2-64I found to reduce MTCT; then SDF1-3’A shown to have no effect on MTCT and others like the DC-SIGNR, CD4, CCL3 and IP-10. The HLA class I was most studied and was generally linked to the protective effect on MTCT. Breast milk constituents were associated to protection against MTCT. However, existing studies in Sub Saharan Africa were done just in few countries and some done without control groups. Contradictory results obtained may be due to different genetic background, type of controls, different socio-cultural and economic environment and population size. More studies are thus needed to better understand the mechanism of transmission or prevention.

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HLA A32 is associated to HIV acquisition while B44 and B*53 are associated with protection against HIV acquisition in perinatally exposed infants

et al. 2019

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Background Human leukocyte antigen (HLA) molecules play a key role in the cellular immune system. They may be determinants of mother-to-child transmission which is the driving force in pediatric HIV infection. We intended to look at the impact of the distribution of these polymorphic HLA genes in the mother-to-child transmission (MTCT) of HIV in Cameroon. Methods A total of 156 mother-baby pairs were enrolled in three hospitals of Yaounde, capital of Cameroon. After the extraction of the DNA from blood samples using the Qiagen Kit as per manufacturer’ instructions, the polymorphism of the HLA class 1 ABC was determined using the PCR- sequence specific primers assay. Results The distribution of HLA class 1 revealed that none of the allele studied was associated with transmitters or non-transmitters, so was not implicated in transmission. The regression analysis showed that HLA A*32 [OR 0.062 (CI; 0.0075 to 0.51)] is associated with HIV acquisition while HLA B*44 [OR 0.47 (CI; 0.21 to 1.14)] and HLA B*53 [OR; 0.14 (CI; 0.018 to 1.22)] were implicated in reducing the acquisition of HIV by infants. The homozygosity of locus C [OR 6.99 (CI; 1.81 to 26.88), p = 0.0027] was found as a risk factor for the acquisition, while the A*32-B*44 haplotype [OR 10.1 (CI 1.17 to 87.87), p = 0.03] was a risk factor for the transmission. Conclusion This study has found that HLA A*32, B*44 and B*53 have an impact in MTCT outcomes. The homozygosity of locus C and the A*32-B*44 haplotype were risk factors for acquisition and transmission respectively. Electronic supplementary material The online version of this article (10.1186/s12887-019-1620-6) contains supplementary material, which is available to authorized users.

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Human Leucocyte Antigen Class I Diversity among Human Immunodeficiency Virus Exposed Negative and Positive Children in Cameroon

Cited by 3 publications

References 41 publications

A Systematic Review on the Influence of Hla-B Polymorphisms on Hiv-1 Mother-to-Child-Transmission

A Systematic Review on the Influence of Hla-B Polymorphisms on Hiv-1 Mother-to-Child-Transmission

Host molecular factors and viral genotypes in the mother-to-child HIV-1 transmission in sub-Saharan Africa

HLA A32 is associated to HIV acquisition while B44 and B*53 are associated with protection against HIV acquisition in perinatally exposed infants

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Human Leucocyte Antigen Class I Diversity among Human Immunodeficiency Virus Exposed Negative and Positive Children in Cameroon

Cited by 3 publications

References 41 publications

A Systematic Review on the Influence of Hla-B Polymorphisms on Hiv-1 Mother-to-Child-Transmission

A Systematic Review on the Influence of Hla-B Polymorphisms on Hiv-1 Mother-to-Child-Transmission

Host molecular factors and viral genotypes in the mother-to-child HIV-1 transmission in sub-Saharan Africa

HLA A*32 is associated to HIV acquisition while B*44 and B*53 are associated with protection against HIV acquisition in perinatally exposed infants

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HLA A32 is associated to HIV acquisition while B44 and B*53 are associated with protection against HIV acquisition in perinatally exposed infants