Human leukocyte antigen allele associations in type‐1 autoimmune hepatitis patients from western India

Shankarkumar, U.; Amarapurkar, Deepak; Kankonkar, S. R.

doi:10.1111/j.1440-1746.2004.03608.x

Cited by 17 publications

(8 citation statements)

References 29 publications

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“…[24][25][26][27] Studies from western India have reported increase in frequency of DRB1*13, DRB1*03, DRB1*15, DRB1*14 alleles in patient group in comparison to the controls. 28,29 Contrary to this, our study has found that DRB1*08 and DRB1*04 to be associated with the disease. On subdividing the AIH type 1 patient group into pediatric and adult it was found that DRB1*04 was associated with the pediatric population and DRB1*08 was associated with the adult population.…”

Section: Discussioncontrasting

confidence: 51%

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Kaur

Minz

Anand

et al. 2014

Journal of Clinical and Experimental Hepatology

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Background: Autoimmune hepatitis is a polygenic disorder of unknown etiology, where genetic factors affect the occurrence and clinical phenotype of the disease. It has been reported as a rare disease entity in the Indian subcontinent. This study was undertaken to investigate the association of HLA alleles with autoimmune hepatitis type 1 and type 2 in north Indian population and to analyze if distinct human leukocyte antigen (HLA) alleles help in characterization of the subtypes of autoimmune hepatitis. Methods: Sixty-eight patients with autoimmune hepatitis and 128 healthy controls were recruited in the study. Out of 68 patients, 55 were diagnosed with autoimmune hepatitis type 1 and 13 with autoimmune hepatitis type 2. The patients and the controls were typed for HLA class II alleles by PCR-SSP method. Results: HLA DRB1*04 and DRB1*08 were found to be significantly associated with autoimmune hepatitis type 1 in north Indian population. It was also observed that DRB1*04, DRB1*13 were significantly associated with pediatric autoimmune hepatitis type 1 and DRB1*08 was significantly associated with adult autoimmune hepatitis type 1. DRB1*14 was significantly associated with autoimmune hepatitis type 2. Conclusion: The study indicates that autoimmune hepatitis in north Indian population is associated with HLA alleles that may help to discriminate the subtypes as autoimmune hepatitis type 1 and type 2. The study also highlights the ethnic variations in the Indian subcontinent in context to the genetic association of HLA with autoimmune diseases. ( J CLIN EXP HEPATOL 2014;4:14-18)

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Section: Discussioncontrasting

confidence: 51%

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Kaur

Minz

Anand

et al. 2014

Journal of Clinical and Experimental Hepatology

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“…DRB1*0101 and DQB1*0301 are reported to be risk factors for the autoimmune condition rheumatoid arthritis,(41;42) while Cw*0102 is associated with both psoriasis(43) and autoimmune hepatitis. (44) Cw*0102, like HLA*B57, can act as ligand for KIR. (45) Lastly, DRB1*0301 is inversely associated with rheumatoid arthritis,(46) consistent with its inverse association with HCV clearance, though we note it also has positive associations with autoimmune hepatitis(47) and systemic lupus erythematosus.…”

Section: Discussionmentioning

confidence: 99%

Specific Human Leukocyte Antigen Class I and Ii Alleles Associated With Hepatitis C Virus Viremia

et al. 2010

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M ore than 4 million women and men in the United States and 150 million people worldwide are estimated to be hepatitis C virus (HCV) seropositive. 1,2 Most of these individuals are chronically infected with the virus and are at high risk of cirrhosis, hepatocellular carcinoma, and liverrelated death. The natural history of HCV infection, however, is highly variable. Some individuals do not become HCV infected despite high levels of exposure. 3 Other individuals may clear HCV RNA following acute infection, and whereas some individuals with long-term HCV viremia remain clinically asymptomatic, others have progressive disease. 4 Indeed, marked variability in natural history is seen even among groups of individuals with single-source exposure to HCV, as occurred in a population of Irish women exposed to HCV-contaminated anti-D immune globulin. 5 Together these observations suggest that host factors, particularly host immune response, play a key role in the regulation of HCV pathogenesis.

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“…HLA-DRB1*1501 (40%), HLA-DRB1*14 (30%), HLA-DRB1*0301 (20%) and HLA-DRB1*1301(15%) were increased in type I AIH patients from western India. 34 Recently, another study indicated that HLA-DRB1*04 (odds ratio: 3.292, p = 0.008) and DRB1*08 (odds ratio: 10.5, p = 0.027) were significantly associated with type I AIH in the north Indian population. In the same cohort, patients with type II AIH were found to be significantly associated with DRB1*14 (odds ratio: 3.5, p = 0.047).…”

Section: Epidemiology Natural History and Genetics Of Aihmentioning

confidence: 98%

Autoimmune Hepatitis in the Asia-Pacific Area

Wang

2017

Journal of Clinical and Translational Hepatology

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Autoimmune hepatitis has been considered as a relatively rare immunological liver disease, especially in the Asia-Pacific area. Although the diagnosis criteria and immunosuppressive treatment regimens have been established, there are still some challenges. According to the different presentations, the personalized management of patients who suffer from this disease, including those with chronic or acute severe onset, the autoantibody-negative phenotype and cirrhosis are necessarily descriptive. Each subgroup of patients should receive an individualized therapy. Here, we review the recent studies of autoimmune hepatitis, mainly focusing on the epidemiology and genetics, personalized diagnostics, individualized treatment strategies, special subgroups and outcomes. Most of the research in the literature is based on Japanese and Chinese populations.

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Human leukocyte antigen allele associations in type‐1 autoimmune hepatitis patients from western India

Abstract: The present study indicates that the HLA susceptibility to type 1 AIH in the different populations studied is complex.

Cited by 17 publications

References 29 publications

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population

Specific Human Leukocyte Antigen Class I and Ii Alleles Associated With Hepatitis C Virus Viremia

Autoimmune Hepatitis in the Asia-Pacific Area

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