Human leukocyte antigen <scp>DQ</scp>2/<scp>DQ</scp>8 positivity in women with history of stillbirth

Cozzolino, Mauro; Serena, Caterina; Calabrò, Antonino; Savi, Elena; Rambaldi, Marianna Pina; Simeone, Serena; Ottanelli, Serena; Mello, Giorgio; Rombolà, G.; Troiano, Gianmarco; Nante, Nicola; Vannuccini, Silvia; Mecacci, Federico

doi:10.1111/aji.13038

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Since the discovery of the first human leukocyte antigen Mac (HLA-A2) by French physician Dausset in 1958, research on HLA has developed rapidly [ 9 ]. HLA is located in region 21.3 of the short arm of chromosome 6, with a length of 4100 kb, and is by far the most polymorphic system known in humans, accounting for about 0.1% of the genes in the human genome [ 10 ]. The gene structure of this region has the following characteristics: (1) the region with the highest concentration and abundance of genes related to immune function, with 39.8% of gene products being immune among 128 functional genes; (2) the region with the highest gene density, with an average of one gene per 16 kb; (3) the region with the strongest polymorphism; (4) the region with the closest relationship to disease.…”

Section: Discussionmentioning

confidence: 99%

Study on the Relationship between Unexplained Recurrent Abortion and HLA-DQ Gene Polymorphism

Tang

Zhu

Shu

et al. 2022

Computational Intelligence and Neuroscience

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Objective. The study aimed to investigate the relationship between human leukocyte antigen (HLA-DQB1) gene variants and recurrent miscarriage. Methods. HLA-DQ gene polymorphisms (PCR-SSP) were detected in 50 couples with recurrent miscarriage (URSA group) and 30 couples with normal births (control group) using sequence-specific primer-guided polymerase chain reaction. Results. The frequency of the DQB1 ∗ 0303 allele in the URSA group (21.50%) was substantially higher than that of the control group (11.67%) ( P = 0.0260 0.05, RR = 1.754); however, the frequency of the DQB1 ∗ 0302 allele in the URSA group (4.00%) was substantially lower than that of the control pair (10.00%) ( P = 0.0318 0.05, RR = 0.400); the frequency of sharing one allele was 46.00% (23/50) in the URSA group and 0.00% (0/30) in the normal control group; the frequency of sharing two alleles was 40.00% (2/50) in the URSA group and 43.33% (13/30) in the normal control group, with no significant difference between the two groups. Conclusion. For the Zhejiang population, HLA-DQB1 ∗ 0303 may be a susceptibility gene for recurrent miscarriage, while HLA-DQB1 ∗ 0302 may be protective against recurrent miscarriage, especially for women.

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Section: Discussionmentioning

confidence: 99%

Study on the Relationship between Unexplained Recurrent Abortion and HLA-DQ Gene Polymorphism

Tang

Zhu

Shu

et al. 2022

Computational Intelligence and Neuroscience

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show abstract

“…In brief, the protocol comprised measurement of maternal blood pressure, maternal blood tests for inherited and acquired thrombophilia, thyroid function, indirect Coombs test, screening for diabetes, serology for TORCH ("Toxoplasmosis", "Others" "Rubeola", "Citomegalovirus", "Herpes"), antiendomysium, anti-transglutaminase, and anti-gliadin antibodies. Genetic tests for the most common polymorphisms associated with celiac disease (HLA DQ2/DQ8) were also performed, as it has already been shown a higher prevalence HLA DQ2/DQ8 in women with a history of stillbirth, mostly in case of suboptimal fetal growth [34]. Patients with celiac disease or gluten sensitivity started a gluten free diet at least 3 months before the conception and throughout the course of the subsequent pregnancy.…”

Section: Methodsmentioning

confidence: 99%

Pregnancy Outcomes Subsequent to Stillbirth—A Single Tertiary-Care Center Experience

Clemenza¹,

Serena²,

Vannuccini³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: Currently, there is little evidence to guide clinical management of pregnancies after stillbirth. Our study aims to evaluate the pregnancy outcome in pregnant women with a previous stillbirth, by applying a standardized protocol for etiologic investigations and subsequent treatment of the underlying etiology. Methods: A retrospective cohort study on a group of 100 women with history of stillbirth, occurred in single pregnancy between 2005 and 2021, was performed. All patients were followed up in their subsequent pregnancies (n = 153) in a tertiary university hospital. During the preconception period causes of stillbirth were investigated and a correction of modifiable risk factors was encouraged with a multidisciplinary approach. Data about pregnancy management, obstetric complications, gestational age at delivery, mode of delivery and neonatal outcomes were collected. Results: The analysis of previous stillbirth revealed that, by using the ReCoDe classification, the most common identifiable causes of death were fetal growth restriction (21%), placental abruption (11%) and "other placenta insufficiencies" (26.7%), whereas 15.8% of stillbirth was unexplained. Out of 153 subsequent pregnancies, 131 (85.62%) resulted in live births, 15 (9.8%) in a first trimester miscarriage, and 7 (4.57%) in second trimester miscarriage; no cases of stillbirth recurrence occurred. Obstetric complications in subsequent pregnancies included gestational diabetes (21.4%), gestational hypertensive disorders (6.1%), intrahepatic cholestasis of pregnancy (3.8%), fetal growth restriction (7.6%) and preterm birth (19.8%). The mean gestational age at delivery was 38 weeks with a mean birth weight of 2886.63 g. Conclusions: Our experience is encouraging as reflecting good outcomes in terms of live birth rate in the subsequent pregnancies, with no cases of recurrence. These results are probably due to extensive preconception investigations with a multidisciplinary approach. A preconception evaluation is, thus, essential to improve maternal and fetal outcome in case of history of stillbirth, aiming to minimize the risk of recurrence.

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Possible effect of the HLA-DQ2/DQ8 polymorphism on autoimmune parameters and lymphocyte subpopulation in recurrent pregnancy losses

Królik¹,

Wrześniak

Jezela‐Stanek³

2022

Journal of Reproductive Immunology

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Human leukocyte antigen DQ2/DQ8 positivity in women with history of stillbirth

Cited by 4 publications

References 30 publications

Study on the Relationship between Unexplained Recurrent Abortion and HLA-DQ Gene Polymorphism

Study on the Relationship between Unexplained Recurrent Abortion and HLA-DQ Gene Polymorphism

Pregnancy Outcomes Subsequent to Stillbirth—A Single Tertiary-Care Center Experience

Possible effect of the HLA-DQ2/DQ8 polymorphism on autoimmune parameters and lymphocyte subpopulation in recurrent pregnancy losses

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