Human Lung Carcinoma Cells Treatment by Herbal Medicines Measured by the Response to Compressional Force Induced by a Laser Trap

Solomon, Rance; Devito, Daniel; Brown, Charles A.; Coopper, James; Crogman, Horace; Erenso, Daniel; Pellizzaro, Aline; Revalee, J.; Farone, Anthony L.; Farone, Mary B.; Gao, Ying

doi:10.1364/biomed.2014.bm3a.6

Cited by 2 publications

(4 citation statements)

References 3 publications

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“…Using Image Pro Plus 6 image analysis software, we measured the diameter of each cells. 32 The statistical distribution of these cells is displayed by the Histogram in Fig. 2(b) .…”

Section: Methodsmentioning

confidence: 99%

“…25 The combination of LT techniques with high-resolution imaging techniques has created a wide range of applications in experimental physics and biomedical research. Some of these applications include transporting a gaseous Bose–Einstein condensate, 26 elastic properties of the human red blood cells (RBCs) 27 – 31 and cancer cells, 32 and protein unfolding and uncoiling of DNA strands. 33 – 35 …”

Section: Introductionmentioning

confidence: 99%

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Elastic property of sickle cell anemia and sickle cell trait red blood cells

et al. 2021

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. Significance: We introduce a model for better calibration of the trapping force using an equal but oppositely directed drag force acting on a trapped red blood cell (RBC). We demonstrate this approach by studying RBCs’ elastic properties from deidentified sickle cell anemia (SCA) and sickle cell trait (SCT) blood samples. Aim: A laser trapping (LT) force was formulated and analytically calculated in a cylindrical model. Using this trapping force relative percent difference, the maximum (longitudinal) and minimum (transverse) radius rate and stiffness were used to study the elasticity. Approach: The elastic property of SCA and SCT RBCs was analyzed using LT technique with computer controlled piezo-driven stage, in order to trap and stretch the RBCs. Results: For all parameters, the results show that the SCT RBC samples have higher elastic property than the SCA RBCs. The higher rigidity in the SCA cell may be due to the lipid composition of the membrane, which was affected by the cholesterol concentration. Conclusions: By developing a theoretical model for different trapping forces, we have also studied the elasticity of RBCs in SCT (with hemoglobin type HbAS) and in SCA (with hemoglobin type HbSS). The results for the quantities describing the elasticity of the cells consistently showed that the RBCs in the SCT display lower rigidity and higher deformability than the RBCs with SCA.

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“…Using Image Pro Plus 6 image analysis software, we measured the diameter of each cells. 32 The statistical distribution of these cells is displayed by the Histogram in Fig. 2(b) .…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elastic property of sickle cell anemia and sickle cell trait red blood cells

et al. 2021

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“…With LT, we can conveniently trap and manipulate dielectric particles as small as a few nanometers in diameter and as large as a few micrometers in size 12,13 [12,13]. LT has the potential to help determine a better therapeutic ratio based on the cellular level, to eradicate radiation-induced tissue toxicity while advancing the sterilization of the cancerous cells 7,8 [7,8]. This technique provides unique means to control the dynamics of small particles and manipulate biological samples at the micron level 17,18 [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…This new approach is combined with TCMs for single cell ionization and is extended to multiple in 4T1 breast carcinoma cells 9 [9]. The cell line was treated with a naturally occurring compound, 2-Dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione (DMDD) extracted from the root of Averrhoa carambola L. produces a significant reduction in the Threshold Radiation Dose in multiple cell ionization was observed and related to the chain effect of ionization by the radiation field 8 [8]. It is well known that the botanical plant (Paeonia suffruticosa) has antitumor, antioxidative, and other health benefits.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Suffruticosol B. in Treating Lung Cancer by Laser Trapping Technique

Goangul

Erenso

Gao

et al. 2022

Preprint

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The biophysical effects of Suffruticosol B. on lung cancer cells were studied. The physical and mechanical changes due to the treatment were statistically analyzed based on areas measured from the images captured for each cell once free, trapped, and released. Measurements were conducted on the untreated A549 cells for comparisons. The result showed that the treatment damages the internal structure of the cells, resulting in the collapse of the spherically A549 cells as the average area indicated a relative increase with the length of the treatment period. The cells’ response indicated that the elastic properties of the carcinoma cells had been reduced due to the treatment by Suffruticosol B. Changing the trap’s power and time constant predicted interesting behavior for the A549 cells’ relaxation rate. We have shown that Oligostilbene can play a role an effective in treating cancer.

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Human Lung Carcinoma Cells Treatment by Herbal Medicines Measured by the Response to Compressional Force Induced by a Laser Trap

Cited by 2 publications

References 3 publications

Elastic property of sickle cell anemia and sickle cell trait red blood cells

Elastic property of sickle cell anemia and sickle cell trait red blood cells

The Effectiveness of Suffruticosol B. in Treating Lung Cancer by Laser Trapping Technique

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