Human menopausal gonadotropins: A justifiable therapy in ovulatory women with long-standing idiopathic infertility

Welner, Sandra L.; DeCherney, Alan H.; Polan, Mary Lake

doi:10.1016/0002-9378(88)90789-2

Cited by 51 publications

(17 citation statements)

References 17 publications

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“…4). These rates are higher compared to the TI studies of Welner et al (1988), Fisch et al (1989 and Martinez et al (1991) and similar to the studies of IUI by Hewitt et al (1985), Yovich and Matson (1988) and Deaton et al (1990), but lower than those reported by KarlstrOm et al (1993) for TI, or by Dodson and Haney (1991) for IUI. The higher pregnancy rates reported by the latter groups may be explained by ovarian hyperstimulation, which we do not employ because of the risk of multiple pregnancy (Friedman 1990).…”

Section: Discussionsupporting

confidence: 70%

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A three step protocol for the treatment of idiopathic subfertility

Berg

Seifert-Klauss

Lauritzen

et al. 1994

Arch Gynecol Obstet

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650 couples with idiopathic subfertility (mean duration: 5.7 year, range 2-21 years) were treated during 2870 cycles by three assisted conception methods (each involving mild ovarian stimulation): I timed intercourse (TI), II intrauterine insemination (IUI). III in vitro fertilization/embryo transfer (IVF/ET). Treatment started with TI in most cases and then changed to IUI after three to six cycles. Couples who failed to conceive were treated after another 3-9 cycles by IVF/ET. An overall cumulative pregnancy rate of 80.2% was reached after 18 treatment months. The pregnancy rates per treatment cycle were: TI 5.3%, IUI 6.9%, IVF/ET 15.8% (per oocyte retrieval).

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Section: Discussionsupporting

confidence: 70%

“…With respect to pregnancy rate per cycle, TI (2.5-3.2%, Welner et al 1988;Fisch et al 1989;Martinez et al 1991) and IUI (6-9.5%, Hewitt et al 1985;Yovich and Matson 1988;Deaton et al 1990) seem to be less effective than IVF-ET/GIFT (20-33 % per transfer; Hewitt et al 1985;Leeton et al 1987;Medical Resarch International et al 1991).…”

Section: Introductionmentioning

confidence: 93%

A three step protocol for the treatment of idiopathic subfertility

Berg

Seifert-Klauss

Lauritzen

et al. 1994

Arch Gynecol Obstet

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“…Serhal et al [18] investigated the added advantage of superovulation with IUI: 41 % preg nancies with IUI and superovulation; 6.7% pregnancies with IUI alone and 12% pregnancies with superovula tion alone. An identical pregnancy rate was achieved by Weiner et al [19], who applied gonadotropin superovu lation to patients with unexplained infertility, while they were on the waiting list for IVF-ET.…”

Section: Discussionmentioning

confidence: 78%

Pregnancies during and after Homologous Intrauterine Insemination Cycles

Valkenburg

Evers

Dumoulin

1990

Gynecol Obstet Invest

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Results of intrauterine insemination (IUI) in 39 couples are presented. Indications were male subfertility, cervical factor, unexplained infertility and immunological factor. The patients received a total of 119 treatment cycles. Nine pregnancies were achieved (23.1%) during IUI treatment. The monthly fecundity rate (MFR) during treatment was 7.6%. After stopping IUI, within a follow-up of 1 year 13 pregnancies occurred. Seven pregnancies occurred spontaneously without invasive treatment methods. The MFR was calculated to be 4.8% for this group. We conclude that couples with IUI treatment do achieve pregnancies more quickly, but IUI does not influence a patient’s eventual chance to become pregnant.

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“…It is also possible that a larger dose of gonadotropin might be necessary to improve the process of follicle development in idiopathic infertile patients. Welner et al had already reported that a higher pregnancy rate could be achieved with higher doses of gonadotropins in cases of long-standing infertility of unknown etiology (5).…”

Section: Discussionmentioning

confidence: 98%

Intraovarian arterial blood flow resistance in oligomenorrheal infertile women

Nakagawa

Takahashi

Ito

et al. 2006

J Assist Reprod Genet

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Purpose:Intraovarian arterial blood flows before and after follicular rupture in ovulation induced cycles were examined by transvaginal color flow Doppler imaging. The changes observed in the intraovarian arterial resistance before and after ovulation in relation to the regularity of menstruation and several other parameters were analyzed. Methods: In a prospective study, 22 patients undergoing infertility treatment in our center were recruited. Patients were divided into two subgroups, according to their menstrual regularity (regular menstrual group and oligomenorrheal group) and 42 cycles were studied. All patients received the same FSH low-dose stimulation treatment. The relationship between the post and preovulatory arterial pulsatility indexes (PI) was analyzed. Cycles that showed a decrease in their PI after ovulation of 10% or more were considered "profoundly decreased cycles." Cycles from the same patients without ovulatory stimulation (natural cycles) were used as control. Results: In the regular menstrual group the rate of profoundly decreased cycles during FSH stimulation was 63.2%, which was similar to the rate observed in natural cycles. In the oligomenorrheal group the rate of profoundly decreased cycles during natural cycles was 14.3%, but in FSH ovulation induction cycles this rate was significantly increased (47.6%, p < 0.05). In addition, the pregnancy rate per cycle in the oligomenorrheal group was significantly higher than that in the regular menstrual group (p = 0.03). Conclusions: Oligomenorrheal patients presented a higher rate in the decrease of their PI values after FSH stimulation, which is essential to achieve pregnancy. This elevated rate of reduction implies that oligomenorrheal patients have increased incidence of disturbance in their ovulatory process when compared to normal cycling patients. Thus, ovulation induction with FSH, in oligomenorrheal patients resulted in a higher pregnancy rate in this group.

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Human menopausal gonadotropins: A justifiable therapy in ovulatory women with long-standing idiopathic infertility

Cited by 51 publications

References 17 publications

A three step protocol for the treatment of idiopathic subfertility

A three step protocol for the treatment of idiopathic subfertility

Pregnancies during and after Homologous Intrauterine Insemination Cycles

Intraovarian arterial blood flow resistance in oligomenorrheal infertile women

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