Human Metapneumovirus and Other Respiratory Viral Infections in Children Attending a Day Care Center

Montejano-Elías, Lizette; Alpuche-Solís, Ángel G.; Zárate-Chávez, Verónica; Sánchez-Alvarado, Josefina; Hernández-Salinas, Alba E.; Noyola, Daniel E.

doi:10.1097/inf.0b013e3181aa6c3e

Cited by 10 publications

(7 citation statements)

References 10 publications

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“…In Mexico, the first study in which the presence of this virus was determined was published in 2005 [40]. Subsequently, other Mexican studies demonstrated its importance in the child population [16;41–42]. Studies such as that of Diaz et al [16] demonstrated that HMPV was mostly associated with severe acute respiratory infections instead of mild and moderate infections.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of non-influenza respiratory viruses in acute respiratory infection cases in Mexico

et al. 2017

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BackgroundAcute respiratory infections are the leading cause of morbidity and mortality worldwide. Although a viral aetiological agent is estimated to be involved in up to 80% of cases, the majority of these agents have never been specifically identified. Since 2009, diagnostic and surveillance efforts for influenza virus have been applied worldwide. However, insufficient epidemiological information is available for the many other respiratory viruses that can cause Acute respiratory infections.MethodsThis study evaluated the presence of 14 non-influenza respiratory viruses in 872 pharyngeal exudate samples using RT-qPCR. All samples met the operational definition of a probable case of an influenza-like illness or severe acute respiratory infection and had a previous negative result for influenza by RT-qPCR.ResultsThe presence of at least one non-influenza virus was observed in 312 samples (35.8%). The most frequent viruses were rhinovirus (RV; 33.0%), human respiratory syncytial virus (HRSV; 30.8%) and human metapneumovirus (HMPV; 10.6%). A total of 56 cases of co-infection (17.9%) caused by 2, 3, or 4 viruses were identified. Approximately 62.5% of all positive cases were in children under 9 years of age.ConclusionIn this study, we identified 13 non-influenza respiratory viruses that could occur in any season of the year. This study provides evidence for the prevalence and seasonality of a wide range of respiratory viruses that circulate in Mexico and constitute a risk for the population. Additionally, our data suggest that including these tests more widely in the diagnostic algorithm for influenza may reduce the use of unnecessary antibiotics, reduce the hospitalisation time, and enrich national epidemiological data with respect to the infections caused by these viruses.

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Section: Discussionmentioning

confidence: 99%

Prevalence of non-influenza respiratory viruses in acute respiratory infection cases in Mexico

et al. 2017

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“…This virus recently has been identified and has been associated with ARI in children and adults [ 25 , 26 ]. In Mexico, a few studies on the prevalence of hMPV have been conducted in the pediatric population, and the frequency has been reported to range from 6% to 20% [ 27 - 29 ]. In this study, this virus was detected in 22% of children, a value that is very similar to what has been reported in Mexico [ 28 , 29 ] and elsewhere (reviewed in [ 30 ]).…”

Section: Discussionmentioning

confidence: 99%

“…In Mexico, a few studies on the prevalence of hMPV have been conducted in the pediatric population, and the frequency has been reported to range from 6% to 20% [ 27 - 29 ]. In this study, this virus was detected in 22% of children, a value that is very similar to what has been reported in Mexico [ 28 , 29 ] and elsewhere (reviewed in [ 30 ]). Furthermore, our results contrast with those of other studies in which RSV ranks as the most frequent virus in the pediatric population with ARI [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study

et al. 2015

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BackgroundAcute respiratory infections (ARIs) cause illness. Children under five years of age are highly vulnerable to these infections. Viral coinfection or multiple viral infection is a variable that can have a significant impact on the evolution of these diseases.MethodsThis cross-sectional study was carried out in Mexican children (under five years of age) who had an ARI and who were treated by an emergency service in a hospital in Guadalajara, Jalisco, Mexico. The viral etiology, as well as the presence of multiple viral infections, was determined. A structured questionnaire was used to obtain demographic and clinical information. Odds ratio (OR) was calculated, and univariate and multivariate analyses using logistic regression were performed.ResultsIn the study population, metapneumovirus (hMPV) was the most frequent virus (22%), followed by adenovirus (hAD) (16%), respiratory syncytial virus (RSV) (14%), rhinovirus (hRV) (12%), bocavirus (hBoV) (9%), influenza virus (IF) (7%), and parainfluenza (PIF) (4%). The frequency of viral coinfections was 31.62%, and multiple logistic regression analysis revealed that hMPV, RSV, PIF, and hBoV were independently associated with multiple viral infection. No difference was found in the clinical manifestation of children with simple and multiple infections. Simple hMPV infection was associated with patients who presented with severe ARI. Using a multivariate analysis, we found that overcrowding is associated with coinfection when the viral etiology was hRV (OR = 2.56, 95% confidence interval (CI) 1.07 to 6.13), IF (OR = 2.56, 95% CI 1.07 to 6.13), PIF (OR = 2.96, 95% CI 1.15 to 7.65), hAD (OR = 2.56, 95% CI 1.07 to 6.13), and hBoV (OR = 2.9, 95% CI 1.14 to 7.34).ConclusionsViral coinfections are frequent in children requiring treatment by an emergency service. However, the severity of ARI is similar to that of children with a simple infection. The hMPV is common and may confer a significant disease burden in the Mexican population. Finally, overcrowding is a housing characteristic that favors the development of coinfections.Electronic supplementary materialThe online version of this article (doi:10.1186/s13052-015-0133-7) contains supplementary material, which is available to authorized users.

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“…15,16 Statistical analysis Comparison of patient groups was carried out using SPSS 14.0 for Windows. Categorical variables were compared using the chi-square or Fisher's exact test, as appropriate.…”

Section: Rsv Detectionmentioning

confidence: 99%

Pandemic influenza A(H1N1) 2009 and respiratory syncytial virus associated hospitalizations

Lovato-Salas

Matienzo-Serment

Monjarás‐Ávila

et al. 2010

Journal of Infection

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Human Metapneumovirus and Other Respiratory Viral Infections in Children Attending a Day Care Center

Cited by 10 publications

References 10 publications

Prevalence of non-influenza respiratory viruses in acute respiratory infection cases in Mexico

Prevalence of non-influenza respiratory viruses in acute respiratory infection cases in Mexico

Viral coinfection in acute respiratory infection in Mexican children treated by the emergency service: A cross-sectional study

Pandemic influenza A(H1N1) 2009 and respiratory syncytial virus associated hospitalizations

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