Human metapneumovirus infections in Mexico: epidemiological and clinical characteristics

Abstract

The human metapneumovirus (hMPV) is a recently described respiratory RNA virus that mainly affects children. To date there has not been a report that describes the detection of this virus in Mexico. This study was performed to detect hMPV in hospitalized Mexican children with respiratory infections, and describe their epidemiological and clinical characteristics. Nasal wash samples from 558 children younger than 3 years of age with the admission diagnosis of a respiratory tract infection were evaluated. Respiratory viruses were detected in 221 children The clinical presentation of an hMPV infection was indistinguishable from other respiratory infections. Except for one death, the outcomes of the hMPV infections were good. In this study, among the viruses routinely tested for, hMPV was the second most common agent, after RSV, in children younger than 3 years of age hospitalized with respiratory tract infections.

Adenoviruses C in non-hospitalized Mexican children older than five years of age with acute respiratory infection

“…Furthermore, most of the studies have investigated respiratory syncytial viruses and recently metapneunovirus, especially in children during the first two years of life (Golubjatnikov et al 1975, Tirado et al 1995, Bustamante-Calvillo et al 2001, Manjarrez et al 2003, Noyola et al 2005 . Therefore the aim of this paper was to investigate the presence of AdV associated to ARI in non-hospitalized children older than five years old, as an example of adenovirus infection in a community, and at the same time to identify the AdV species involved in these infections.…”

Detection of human metapneumovirus in infants with acute respiratory tract infection

“…in a study by caracciolo et al (13), the incidence of hMPV infection was 25. in our study, all hMPV-positive children, 2 hospitalized and 6 non-hospitalized, were diagnosed with bronchiolitis. hMPV has thus far been identified in children with either upper or lower respiratory tract infection or both, asthma exacerbation, croup, or influenza-like illness (4,9,8,12,(14)(15)(16). Bronchiolitis is the most common diagnosis in children identified as having hMPV infection, while upper respiratory infection, pneumonia and asthma exacerbations have been reported less frequently (4,8,(12)(13)(14)(15).…”

“…showing that hMPV has both seasonal and annual distribution (8,(12)(13)(14)(15). in a study by caracciolo et al (13), the incidence of hMPV infection was 25. in our study, all hMPV-positive children, 2 hospitalized and 6 non-hospitalized, were diagnosed with bronchiolitis.…”

“…hMPV has thus far been identified in children with either upper or lower respiratory tract infection or both, asthma exacerbation, croup, or influenza-like illness (4,9,8,12,(14)(15)(16). Bronchiolitis is the most common diagnosis in children identified as having hMPV infection, while upper respiratory infection, pneumonia and asthma exacerbations have been reported less frequently (4,8,(12)(13)(14)(15). in the study by dollner et al (15), upper respiratory tract infections and mild-to-severe bronchiolitis were most common, but a relatively high proportion of hospitalized children developed severe pneumonia.…”

Human Metapneumovirus Infections in Children

“…Since then, hMPV has been identifi ed wordwide (2)(3)(4)(5)(6)(7)(8)(9). In temperate regions, hMPV circulates mainly during the winter (6,7,(10)(11)(12).…”