Detection of human metapneumovirus in infants with acute respiratory tract infection

Mammas,

doi:10.3892/mmr.2011.416

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…A Greek study found HMPV in 16.5% of samples, followed by HRV (14.3%) [39]. In the same country, a more recent study found HMPV infection in 6% of cases in 127 hospitalized infants under 12 months of age, all with a moderate clinical picture [40]. In our sample, the average age of children was 7.5 months.…”

Section: Resultssupporting

confidence: 50%

Virologic study of acute lower respiratory tract infections in children admitted to the paediatric department of Blida University Hospital, Algeria

Derrar¹,

Izri²,

Kaddache³

et al. 2019

New Microbes and New Infections

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Acute lower respiratory tract infections (ALRTI) such as pneumonia and bronchiolitis are major causes of mortality and morbidity in children under 5 years of age. The main microbial agents responsible for ALRTI are either bacterial agents ( Streptococcus pneumoniae, Haemophilus influenzae type b, Mycoplasma pneumoniae ) or viruses (respiratory syncytial virus (RSV, also known as human orthopneumovirus), Myxovirus influenzae, Myxovirus parainfluenzae, adenovirus) [1]. More recently, other viruses (rhinovirus, metapneumovirus, coronavirus, bocavirus) have been implicated in ALRTI; their identification has been facilitated by new molecular biology techniques such as real-time PCR. To our knowledge, these emerging viruses have never been the subject of epidemiologic studies in our country.

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Section: Resultssupporting

confidence: 50%

Virologic study of acute lower respiratory tract infections in children admitted to the paediatric department of Blida University Hospital, Algeria

Derrar¹,

Izri²,

Kaddache³

et al. 2019

New Microbes and New Infections

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“…It has frequently been reported that infection of RSV and hMPV result in same or similar symptoms and were indistinguishable on clinical basis [9][10][11]36,37]. However, our analysis of association produced somehow different results: hMPV was more directly related with VSARI and thus improved risk of pneumonia, while RSV was more related to risk of bronchiolitis.…”

Section: Discussionmentioning

confidence: 63%

“…Diagnosis of ARI is complicated by the wide range of potential pathogens that can present with similar clinical symptoms [10,11]. In recent years, the introduction of nucleic acid based diagnostic tests has markedly improved our ability in understanding viral etiology among ARI patients [12].…”

Section: Introductionmentioning

confidence: 99%

Viral Etiology and Clinical Profiles of Children with Severe Acute Respiratory Infections in China

et al. 2013

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BackgroundNo comprehensive analysis is available on the viral etiology and clinical characterization among children with severe acute respiratory infection (SARI) in China during 2009 H1N1 pandemic and post-pandemic period.MethodsCohort of 370 hospitalized children (1 to 72 months) with SARI from May 2008 to March 2010 was enrolled in this study. Nasopharyngeal aspirate (NPA) specimens were tested by a commercial assay for 18 respiratory viral targets. The viral distribution and its association with clinical character were statistically analyzed.ResultsViral pathogen was detected in 350 (94.29%) of children with SARI. Overall, the most popular viruses were: enterovirus/rhinovirus (EV/RV) (54.05%), respiratory syncytial virus (RSV) (51.08%), human bocavirus (BoCA) (33.78%), human parainfluenzaviruse type 3 (PIV3) (15.41%), and adenovirus (ADV) (12.97%). Pandemic H1N1 was the dominant influenza virus (IFV) but was only detected in 20 (5.41%) of children. Moreover, detection rate of RSV and human metapneumovirus (hMPV) among suburb participants were significantly higher than that of urban area (P<0.05). Incidence of VSARI among suburb participants was also significant higher, especially among those of 24 to 59 months group (P<0.05).ConclusionPiconaviruses (EV/RV) and paramyxoviruses are the most popular viral pathogens among children with SARI in this study. RSV and hMPV significantly increase the risk of SARI, especially in children younger than 24 months. Higher incidence of VSARI and more susceptibilities to RSV and hMPV infections were found in suburban patients.

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“…Inflammatory outcomes during HMPV infection are mediated by virus-induced cytopathology and the secretion of cytokines and chemokines [ 15 , 16 ]. Clinical evidence indicates that HMPV induces neutrophil infiltration and associated mediators within the airways of infants with bronchiolitis [ 17 ], providing evidence of the neutrophilic inflammatory response in vivo and highlighting the importance of these cells as a potential target of therapeutic intervention for treatment of bronchiolitis in infected children.…”

Section: Introductionmentioning

confidence: 99%

Human Metapneumovirus Attachment Protein Contributes to Neutrophil Recruitment into the Airways of Infected Mice

Cheemarla

Guerrero-Plata

2017

Viruses

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Human Metapneumovirus (HMPV) is a leading respiratory pathogen that causes lower respiratory tract infections worldwide. Acute HMPV infection induces an exacerbated inflammatory neutrophilic response leading to bronchiolitis and pneumonia. However, the mechanism by which the virus regulates neutrophil infiltration into the airways still remains unexplored. In this work, we used an experimental mouse model of HMPV infection to demonstrate that the attachment (G) protein of HMPV contributes to the recruitment of neutrophils into the airways and modulate the production of neutrophil chemoattractants and Type I IFN responses, specifically IFN-α. These findings provide the first evidence that the HMPV G protein contributes to the in vivo neutrophilic response to HMPV infection and furthers our understanding on virus induced inflammatory responses in the airways.

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Detection of human metapneumovirus in infants with acute respiratory tract infection

Cited by 7 publications

References 14 publications

Virologic study of acute lower respiratory tract infections in children admitted to the paediatric department of Blida University Hospital, Algeria

Virologic study of acute lower respiratory tract infections in children admitted to the paediatric department of Blida University Hospital, Algeria

Viral Etiology and Clinical Profiles of Children with Severe Acute Respiratory Infections in China

Human Metapneumovirus Attachment Protein Contributes to Neutrophil Recruitment into the Airways of Infected Mice

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