Human microbiome is a diagnostic biomarker in hepatocellular carcinoma

Rao, Benchen; Lou, Jiamin; Wang, Weijie; Li, Ang; Cui, Guangying; Yu, Zujiang; Ren, Zhigang

doi:10.1016/j.hbpd.2020.01.003

Cited by 26 publications

(18 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, HCC development is strongly associated with gut dysbiosis. Interestingly, changes of oral microbiota profiles have been reported in HCC patients compared to healthy subjects [183][184][185]. HCC patients showed high abundance of the genera Haemophilus, Porphyromonas, and Filifactor in the salivary microbiota [184].…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer

Park

Hwang

Lim

et al. 2021

Cancers

140

View full text Add to dashboard Cite

It is well-known that microbiota dysbiosis is closely associated with numerous diseases in the human body. The oral cavity and gut are the two largest microbial habitats, playing a major role in microbiome-associated diseases. Even though the oral cavity and gut are continuous regions connected through the gastrointestinal tract, the oral and gut microbiome profiles are well-segregated due to the oral–gut barrier. However, the oral microbiota can translocate to the intestinal mucosa in conditions of the oral–gut barrier dysfunction. Inversely, the gut-to-oral microbial transmission occurs as well in inter- and intrapersonal manners. Recently, it has been reported that oral and gut microbiomes interdependently regulate physiological functions and pathological processes. Oral-to-gut and gut-to-oral microbial transmissions can shape and/or reshape the microbial ecosystem in both habitats, eventually modulating pathogenesis of disease. However, the oral–gut microbial interaction in pathogenesis has been underappreciated to date. Here, we will highlight the oral–gut microbiome crosstalk and its implications in the pathogenesis of the gastrointestinal disease and cancer. Better understanding the role of the oral–gut microbiome axis in pathogenesis will be advantageous for precise diagnosis/prognosis and effective treatment.

show abstract

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer

Park

Hwang

Lim

et al. 2021

Cancers

140

View full text Add to dashboard Cite

show abstract

“…Depending on the studies, the dysbiosis is characterized by increased Escherichia coli ( 39 ), increased Bacteroides ( 38 ), and H. pylori presence has even been detected in liver samples from HCC patients ( 40 ). Rao et al suggested using patient's microbiota signature from tongue swab as a non-invasive tool for HCC diagnosis ( 10 ).…”

Section: Involvement Of the Gut-microbiota In Liver Diseasesmentioning

confidence: 99%

“…A healthy microbiota exerts protective effects ( 7 , 8 ), highlighting the importance of considering therapeutic interventions targeting patients microbiota to slow down the progression of chronic liver diseases. However, growing evidence from clinical studies and experimental models show the involvement of gut-derived signals in the modulation of numerous liver diseases, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcohol-associated hepatitis, cholestatic liver diseases, and in the progression to cirrhosis and hepatocellular carcinoma (HCC) ( 5 , 6 , 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular and Cellular Mediators of the Gut-Liver Axis in the Progression of Liver Diseases

et al. 2021

View full text Add to dashboard Cite

The gut-liver axis covers the bidirectional communication between the gut and the liver, and thus includes signals from liver-to-gut (e.g., bile acids, immunoglobulins) and from gut-to-liver (e.g., nutrients, microbiota-derived products, and recirculating bile acids). In a healthy individual, liver homeostasis is tightly controlled by the mostly tolerogenic liver resident macrophages, the Kupffer cells, capturing the gut-derived antigens from the blood circulation. However, disturbances of the gut-liver axis have been associated to the progression of varying chronic liver diseases, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and primary sclerosing cholangitis. Notably, changes of the gut microbiome, or intestinal dysbiosis, combined with increased intestinal permeability, leads to the translocation of gut-derived bacteria or their metabolites into the portal vein. In the context of concomitant or subsequent liver inflammation, the liver is then infiltrated by responsive immune cells (e.g., monocytes, neutrophils, lymphoid, or dendritic cells), and microbiota-derived products may provoke or exacerbate innate immune responses, hence perpetuating liver inflammation and fibrosis, and potentiating the risks of developing cirrhosis. Similarly, food derived antigens, bile acids, danger-, and pathogen-associated molecular patterns are able to reshape the liver immune microenvironment. Immune cell intracellular signaling components, such as inflammasome activation, toll-like receptor or nucleotide-binding oligomerization domain-like receptors signaling, are potent targets of interest for the modulation of the immune response. This review describes the current understanding of the cellular landscape and molecular pathways involved in the gut-liver axis and implicated in chronic liver disease progression. We also provide an overview of innovative therapeutic approaches and current clinical trials aiming at targeting the gut-liver axis for the treatment of patients with chronic liver and/or intestinal diseases.

show abstract

“…Gut microbiome can promote hepatocellular carcinoma (HCC; ref. 43) by various mechanisms including retrograde translocation from gut to liver via hepatic portal vein, leaky gut, microbe-associated molecular patterns, and microbial metabolites (44). Patients with cirrhosis are at a higher risk of developing HCC; hence, gut dysbiosis associated with cirrhosis may have predictive value.…”

Section: Microbiota As An Upcoming Diagnostic and Prognostic Tool In Cancer Managementmentioning

confidence: 99%

The Microbiome and Cancer: Creating Friendly Neighborhoods and Removing the Foes Within

Parida

Sharma

2021

Cancer Research

View full text Add to dashboard Cite

The human body is colonized by the microbial cells that are estimated to be as abundant as human cells, yet their genome is roughly 100 times the human genome, providing significantly more genetic diversity. The past decade has observed an explosion of interest in examining the existence of microbiota in the human body and understanding its role in various diseases including inflammatory bowel disease, neurologic diseases, cardiovascular disorders, and cancer. Many studies have demonstrated differential community composition between normal tissue and cancerous tissue, paving the way for investigations focused on deciphering the cause-and-effect relationships between specific microbes and initiation and progression of various cancers. Also, evolving are the strategies to alter tumor-associated dysbiosis and move it toward eubiosis with holistic approaches to change the entire neighborhood or to neutralize pathogenic strains. In this review, we discuss important pathogenic bacteria and the underlying mechanisms by which they affect cancer progression. We summarize key microbiota alterations observed in multiple tumor niches, their association with clinical stages, and their potential use in cancer diagnosis and management. Finally, we discuss microbiota-based therapeutic approaches.

show abstract

Human microbiome is a diagnostic biomarker in hepatocellular carcinoma

Cited by 26 publications

References 77 publications

Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer

Oral–Gut Microbiome Axis in Gastrointestinal Disease and Cancer

Molecular and Cellular Mediators of the Gut-Liver Axis in the Progression of Liver Diseases

The Microbiome and Cancer: Creating Friendly Neighborhoods and Removing the Foes Within

Contact Info

Product

Resources

About