Human microbiota and effectiveness of cancer chemotherapy

Shvets, Y.; Lukianova, N Yu; Чехун, В Ф

doi:10.32471/exp-oncology.2312-8852.vol-42-no-2.14611

Cited by 8 publications

(3 citation statements)

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“…In fact, a good balance between the gut microbiota and the immune system is a decisive key to maintaining the effectiveness of anticancer chemotherapy [ 90 ]. Elimination of the microbiota by administering broad-spectrum antibiotics alters host response, since genes that promote cancer metabolism and progression are upregulated, with simultaneous downregulation in inflammatory, phagocytic, and antigen presentation pathways [ 91 ].…”

Section: Elective Therapy In Lung Cancer and The Role Of The Microbiotamentioning

confidence: 99%

Role of the Microbiota in Lung Cancer: Insights on Prevention and Treatment

Pizzo¹,

Maroccia

Ferri³

et al. 2022

IJMS

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The microbiota is increasingly recognized as a critical player in cancer onset and progression and response to cancer chemotherapy treatment. In recent years, several preclinical and clinical studies have evidenced the involvement of microbiota in lung cancer, one of the world’s deadliest cancers. However, the mechanisms by which the microbiota can impact this type of cancer and patient survival and response to treatments remain poorly investigated. In this review, the peculiarities of the gut and lung microbial ecosystems have been highlighted, and recent findings illustrating the possible mechanisms underlying the microbiota–lung cancer interaction and the host immune response have been discussed. In addition, the mucosal immune system has been identified as a crucial communication frame to ease interactive dynamics between the immune system and the microbiota. Finally, the use of specific next-generation intestinal probiotic strains in counteracting airway diseases has been evaluated. We believe that restoring homeostasis and the balance of bacterial microflora should become part of the routine of integrated cancer interventions, using probiotics, prebiotics, and postbiotics, and promoting a healthy diet and lifestyle.

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Section: Elective Therapy In Lung Cancer and The Role Of The Microbiotamentioning

confidence: 99%

Role of the Microbiota in Lung Cancer: Insights on Prevention and Treatment

Pizzo¹,

Maroccia

Ferri³

et al. 2022

IJMS

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“…The sequences obtained are mapped onto reference genomes to obtain the relative quantification of taxa, from which the microbial diversity is derived, or subjected to de novo assembly for the identification of new phyla [41]. The Metagenomics of the Human Intestinal Tract and the Human Microbiome Project have provided the most integrated view of humanassociated microbes: 2172 species have been isolated in human gut microbiota [42], and a healthy gut microbiota is mainly dominated by Bacteroidetes and Firmicutes, while Proteobacteria, Verrucomicrobia, Actinobacteria and several other phyla are present in smaller proportions [43].…”

Section: The Human Gut Microbiotamentioning

confidence: 99%

Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis

Maglione

Zuccalà

Tosi

et al. 2021

Genes

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As a complex disease, Multiple Sclerosis (MS)’s etiology is determined by both genetic and environmental factors. In the last decade, the gut microbiome has emerged as an important environmental factor, but its interaction with host genetics is still unknown. In this review, we focus on these dual aspects of MS pathogenesis: we describe the current knowledge on genetic factors related to MS, based on genome-wide association studies, and then illustrate the interactions between the immune system, gut microbiome and central nervous system in MS, summarizing the evidence available from Experimental Autoimmune Encephalomyelitis mouse models and studies in patients. Finally, as the understanding of influence of host genetics on the gut microbiome composition in MS is in its infancy, we explore this issue based on the evidence currently available from other autoimmune diseases that share with MS the interplay of genetic with environmental factors (Inflammatory Bowel Disease, Rheumatoid Arthritis and Systemic Lupus Erythematosus), and discuss avenues for future research.

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“…These include the polyphenolic anthocyanins (AC, 23, 24) and their active metabolite protocatechuic acid Peiffer et al, 2014), as well as the active metabolites of ellagic acid, the urolithins Kujawska & Jodynis-Liebert, 2020). In parallel with these findings, other groups have demonstrated that ones microbiome may affect their response to chemotherapy including colonic, breast, and pancreatic cancers (Khodavirdipour, Jamshidi, Nejad, Zandi, & Zarean, 2020;Shvets, Lukianova, & Chekhun, 2020;Zhang, Gao, Li, Wang, & Liu, 2020). This relationship however appears complex as some chemotherapeutics target the cancer cells while also negatively affecting the host's microbiome (Campbell, Gagnon, & Rubin, 2019;Domalaon et al, 2019;Flórez, Sierra, Ruas-Madiedo, & Mayo, 2016, Nicholson et al, 2012.…”

Section: Introductionmentioning

confidence: 96%

Modulation of the host microbiome by black raspberries or their components and the therapeutic implications in cancer

Peiffer

2020

Food Frontiers

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Black raspberries (BRB) and their components have been demonstrated to prevent and inhibit the progression of cancers including oral, breast, esophageal, and colon in both preclinical studies and human clinical trials. The mechanism for their anticancer effect appears to vary by organ system, and include their anti-inflammatory, antiproliferative, antiangiogenic, and pro-apoptotic properties. Given findings that suggest that the host microbiome plays a distinct role in the development and progression of cancer, there has been a recent focus on discerning if BRB and their constituents modulate gut microbe levels. This review summarizes the reported effects BRB and their constituents have on the human microbiome and the implications that this has for their use in conjunction with traditional chemotherapies. BRB and their components have been shown to modulate the human gut flora in a positive manner, namely by promoting the population of the gut with "good" bacteria. These include BRB, their major polyphenol anthocyanins (AC), the major metabolite of AC protocatechuic acid (PCA), ellagic acid, and its major metabolite the urolithins. All of these components have been shown to modulate the gut flora, with variations between the individual components. This is in comparison to chemotherapeutic drugs including platinum-based entities and 5-flourouracil, which have been reported to negatively impact the human microbiome, leading to dysbiosis. Given these parallel findings, recent studies have attempted to discern if BRB or their components may reverse the negative effects traditional chemotherapies have on the gut microbiome, and if this results in an improvement in therapeutic outcomes.

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Human microbiota and effectiveness of cancer chemotherapy

Cited by 8 publications

References 0 publications

Role of the Microbiota in Lung Cancer: Insights on Prevention and Treatment

Role of the Microbiota in Lung Cancer: Insights on Prevention and Treatment

Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis

Modulation of the host microbiome by black raspberries or their components and the therapeutic implications in cancer

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