The state of the art of contamination by hazardous emerging substances (HEMS) in the outdoor and indoor environment based on the original resultsof authors and key literature references is presented. History of the newly-recognized group of HEMS is described. The key physico-chemical characteristics of HEMS are emphesized, especially pseudoperzistency of HEMS, non monotonic dose response, chemical cocktails, irreversible binding to proteins, following by constants of partitioning and distribution and different forms of HEMS species in the aquatic environment (molecules, ions, cations and anions, and zwitter ions). Within this study review, representative original results of HEMS detected in the river Danube in the vicinity of Novi Sad,waste water, air and human milk are compiled, gained by numerous international and national projects, more than 30 papers published in the SCI journals and 40 full length papers printed at international and national conferences. Based on concentration levels of HEMS, for the selected HEMS, risk assessment and RQ coefficients were calculated.
Key words: emerging substances, wastewater, Danube surface water, air, human milk, risk assessment