Human Milk Probiotic <i>Lactobacillus fermentum</i> CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants

Maldonado, J.; Cañabate, Francisco; Sempere, Luis; Vela, Francisco J.; Sánchez, Ana; Narbona, Eduardo; López‐Huertas, Eduardo; Geerlings, Arjan; Valero, Antonio D.; Olivares, Mónica; Lara-Villoslada, Federico

doi:10.1097/mpg.0b013e3182333f18

Cited by 212 publications

(202 citation statements)

References 27 publications

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“…IF and FOF containing "probiotics" have also been studied in relation to any potential untoward effects, such as delayed growth, diarrhoea and allergic reactions (Braegger et al, 2011;Gil-Campos et al, 2012;Maldonado et al, 2012;Azad et al, 2013). It has been generally concluded that currently evaluated "probiotic"-supplemented IF do not raise safety concerns with regard to growth or other adverse effects, although in many studies adverse events were inconsistently reported (Azad et al, 2013) and further evaluations of safety in long-term studies are needed (Braegger et al, 2011).…”

Section: "Probiotics" and "Synbiotics"mentioning

confidence: 99%

Scientific Opinion on the essential composition of infant and follow-on formulae

Products¹

2014

EFSA Journal

280

124

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Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on the essential composition of infant and follow-on formula. This opinion reviews the opinion provided by the Scientific Committee on Food in 2003 on the essential requirements of infant and follow-on formulae in light of more recent evidence and by considering the Panel's opinion of October 2013 on nutrient requirements and dietary intakes of infants and young children in the European Union. The minimum content of a nutrient in formula proposed in this opinion is derived from the intake levels the Panel had considered adequate for the majority of infants in the first six months of life in its previous opinion and an average amount of formula consumed during this period. From a nutritional point of view, the minimum contents of nutrients in infant and follow-on formula proposed by the Panel cover the nutritional needs of virtually all healthy infants born at term and there is no need to exceed these amounts in formulae, as nutrients which are not used or stored have to be excreted and this may put a burden on the infant's metabolism. Therefore, the Panel emphasises that maximum amounts should be interpreted not as target values but rather as upper limits of a range which should not be exceeded. There is scientific consensus that breast milk is the preferred food for all healthy infants and provides an adequate supply of all nutrients to support growth and development (with the exception of vitamin K during the first weeks of life and of vitamin D). Whereas the composition of infant formula remains stable over time, breast milk composition changes continuously and therefore infant formula cannot imitate breast milk. © EuropeanAll formulae intended for infants must be safe and suitable to meet the nutritional requirements and promote growth and development of infants born at term when used as a sole source of nutrition during the first months of life, and when used as the principal liquid element in a progressively diversified diet after the introduction of appropriate complementary feeding. Nutrients and substances should be added to formulae for infants only in amounts that serve a nutritional or other benefit. The addition in amounts higher than those serving a benefit or the inclusion of unnecessary substances in formulae may put a burden on the infant's metabolism and/or on other physiological functions, as substances which are not used or stored have to be excreted.The minimum content of a nutrient in formula proposed in this opinion is derived from the intake levels the Panel had considered adequate for the majority of infants in the first half of the first year of life in its previous opinion and an average amount of daily energy intake from formula during this period (500 kcal/day). These minimum amounts should be understood as target values which cover the nutritional needs of virtually all infants born at term for optimal growth and devel...

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Section: "Probiotics" and "Synbiotics"mentioning

confidence: 99%

Scientific Opinion on the essential composition of infant and follow-on formulae

Products¹

2014

EFSA Journal

280

124

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“…A few studies used bacteria isolated from HM. 138,139 Several reasons have been used to support probiotic use in infant formula. Human milk, as previously described, contains a variety of potential probiotic bacteria, such as Bifidobacterium, Lactobacillus and Streptococcus, and these bacteria serve as a source of continuous inoculum to the BF infant GI tract, which may partly contribute to differences in the fecal microbial composition between BF and FF infants.…”

Section: Probioticsmentioning

confidence: 99%

The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

2017

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The development of the human infant intestinal microbiota is a sequential process that begins in utero and continues during the first 2 to 3 years of life. Microbial composition and diversity are shaped by host genetics and multiple environmental factors, of which diet is a principal contributor. An understanding of this process is of clinical importance as the microbiota acquired in early life influence gastrointestinal, immune and neural development, and reduced microbial diversity or dysbiosis during infancy is associated with disorders in infancy and later childhood. The goal of this article was to review the published literature that used culture-independent methods to describe the development of the gastrointestinal microbiota in breast-and formula-fed human infants as well as the impact of prebiotic and probiotic addition to infant formula, and the addition of solid foods.

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“…The most recent QPS Opinion is cited by Adimpong et al (2012) and Bourdichon et al (2012a,b). In other publications this is not always the case (Ambalam et al, 2012;Baffoni et al, 2012;Bonaterra et al, 2012;Bosch et al, 2012;Chaabouni et al, 2012;Christoffersen et al, 2012;Danilova et al, 2012;El-Sharoud et al, 2012;Gálvez et al, 2012;Gardana et al, 2012;Hill, 2012;Maldonado et al, 2012;Nikolic et al, 2012;Permpoonpattana et al, 2012;Popova et al, 2012;Salminen and van Loveren, 2012;Songisepp et al, 2012;Stahl and Barrangou, 2012;Thumu and Halami, 2012;Vogel et al, 2011;Xu et al, 2012).…”

Section: Reference To Qps In the Scientific Literaturementioning

confidence: 96%

Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2012 update)

2012

EFS2

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EFSA is requested to assess the safety of a broad range of biological agents in the context of notifications for market authorisation as sources of food and feed additives, enzymes and plant protection products. The qualified presumption of safety (QPS) assessment was developed for safety risk assessments to provide a harmonised generic pre-assessment to support EFSA"s scientific Panels. The safety of unambiguously defined biological agents at the highest taxonomic unit appropriate for the purpose for which an application is intended and the completeness of the body of knowledge are assessed. Identified safety concerns for a taxonomic unit are where possible and reasonable in number reflected as "qualifications" with a recommendation for the QPS list. The list of QPS recommended biological agents is reviewed and updated annually. Therefore, the only valid list is the one in the most recently published scientific opinion. The 2012 update reviews microorganisms previously assessed including bacteria, yeasts, filamentous fungi and viruses used for plant protection purposes. The BIOHAZ Panel confirmed all taxonomic units previously recommended for the QPS list. The notifications were reviewed. Bacillus firmus was re-evaluated and not recommended for the QPS list. A new recommendation was made for Leuconostoc pseudomesenteroides. Carnobacterium maltaromaticum was assessed for the first time and not recommended for the QPS list. Qualifications for the taxonomic units included in the QPS recommended list were reviewed and confirmed. Filamentous fungi and enterococci were not recommended for the QPS list following updating and reviewing of current scientific knowledge. For Enterococcus faecium recent data indicate a possible distinction between pathogenic and non-pathogenic strains. This is considered too recent knowledge for a QPS recommendation, considering the recent information on the evolution of the epidemiology of Enterococcus infections in humans. Tasks three required, for the taxonomic units included in the QPS recommended list, a review and update of knowledge concerning antimicrobial resistance and a review of the qualifications. The information of the previous opinion was updated by the BIOHAZ Panel and the qualifications were confirmed.The final aspect included a review of the body of knowledge for filamentous fungi and enterococci. The BIOHAZ Panel updated the knowledge of filamentous fungi notified to EFSA. Although numerous data, published since the 2011 QPS opinion, have contributed to partially fulfil gaps of knowledge, too many unknowns remain in 2012 to allow a filamentous fungus to be recommended for the QPS list.Enterococcus faecium is not recommended for the QPS list in spite of the recent scientific knowledge allowing a differentiation of pathogenic from non-pathogenic strains. This is of value for the FEEDAP Scientific Panel dealing with the strain specific notification, but it is too recent knowledge for a QPS recommendation, considering the recent information on the evolution of the ep...

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Human Milk Probiotic Lactobacillus fermentum CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants

Abstract: Administration of a follow-on formula with L. fermentum CECT5716 may be useful for the prevention of community-acquired gastrointestinal and upper respiratory infections.

Cited by 212 publications

References 27 publications

Scientific Opinion on the essential composition of infant and follow-on formulae

Scientific Opinion on the essential composition of infant and follow-on formulae

The role of early life nutrition in the establishment of gastrointestinal microbial composition and function

Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2012 update)

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