Human Mitochondrial Transcription Factor A Reduction and Mitochondrial Dysfunction in Hashimoto’s Hypothyroid Myopathy

Siciliano, Gabriele; Monzani, Fabio; Manca, Maria Laura; Tessa, Alessandra; Caraccio, N; Tozzi, Giulia; Piemonte, Fiorella; Mancuso, Michelangelo; Santorelli, Filippo M.; Ferrannini, Eleuterio; Murri, Luigi

doi:10.1007/bf03402159

Cited by 28 publications

(20 citation statements)

References 36 publications

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“…Resting blood lactate levels in patients with OVH and SCH were similar or slightly increased compared with controls (Monzani et al, 1997;Siciliano et al, 2002). Lactate threshold was achieved at lower levels of maximal voluntary contraction in patients with OVH than in controls (Siciliano et al, 2002). With increasing VO 2 , blood lactate increased with a steeper slope in patients with SCH compared with controls (Caraccio et al, 2005).…”

Section: Cellular Metabolic Systemmentioning

confidence: 66%

“…Based on PCr dynamics, muscle oxidative metabolism in untreated patients with SCH was not impaired at rest or during exercise (Rana et al, 2012). Resting blood lactate levels in patients with OVH and SCH were similar or slightly increased compared with controls (Monzani et al, 1997;Siciliano et al, 2002). Lactate threshold was achieved at lower levels of maximal voluntary contraction in patients with OVH than in controls (Siciliano et al, 2002).…”

Section: Cellular Metabolic Systemmentioning

confidence: 70%

“…Involvement of skeletal muscle is the most prevalent clinical consequence of hypothyroidism, and symptoms such as fatigue, exertional myalgia, and cramps are frequent hallmarks of such an involvement (Reuters et al, 2009;Siciliano et al, 2002). Moreover, clinical signs and symptoms of polyneuropathy, such as proximal weakness and depressed reflex activity (Duyff et al, 2000;Steinacker et al, 2005), and diverse muscular and biochemical changes accompany a hypothyroid status as type II muscle fiber atrophy, enlargement of type I fibers, and glycogen accumulation (Taylor et al, 1992).…”

Section: Discussionmentioning

confidence: 98%

“…They showed muscle fiber and mitochondrial staining abnormalities in untreated patients with OVH (Siciliano et al, 2002). In these patients, an impairment of extra-mitochondrial energy supply was found at rest and during exercise as compared with control muscle (Kaminsky et al, 1992;Taylor, Rajagopalan, & Radda, 1992).…”

Section: Cellular Metabolic Systemmentioning

confidence: 92%

See 3 more Smart Citations

Impact of Overt and Subclinical Hypothyroidism on Exercise Tolerance: A Systematic Review

Lankhaar

Vries

Jansen

et al. 2014

Research Quarterly for Exercise and Sport

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Section: Cellular Metabolic Systemmentioning

confidence: 66%

Section: Cellular Metabolic Systemmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 98%

Section: Cellular Metabolic Systemmentioning

confidence: 92%

See 2 more Smart Citations

Impact of Overt and Subclinical Hypothyroidism on Exercise Tolerance: A Systematic Review

Lankhaar

Vries

Jansen

et al. 2014

Research Quarterly for Exercise and Sport

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show abstract

“…So far, only one study investigated muscle metabolism and exercise tolerance impairments as possible biological mechanisms involved in subclinical hypothyroidism (36). Muscle metabolism has also been suggested to be impaired in Hashimoto's hypothyroid myopathy (37). The few other positive studies on the association between subclinical thyroid dysfunction and functional capacity did not clearly report which biological mechanisms could be involved (16,17).…”

Section: Discussionmentioning

confidence: 99%

Subclinical Thyroid Dysfunction and Functional Capacity Among Elderly

Virgini

Wijsman²,

Rodondi³

et al. 2014

Thyroid

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, 10 on behalf of the PROSPER Study Group Background: Subclinical thyroid dysfunction is common among older people and has been associated with decreased functional capacity but with conflicting data. The aim of this study was to assess the association between subclinical thyroid dysfunction and functional capacity in an elderly population. Methods: We included 5182 participants with a mean age of 75.2 years from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Self-reported functional capacity was assessed using the Barthel Index (BI) and the Instrumental Activities of Daily Living (IADL) scores at baseline and during follow-up. Participants with subclinical hyperthyroidism (n = 65) and subclinical hypothyroidism (n = 173) were compared to euthyroid participants (n = 4944). The association between persistent subclinical thyroid dysfunction and functional capacity and decline was also investigated. Results: At baseline, compared to euthyroid participants (BI 19.73 -SE 0.06; IADL 13.52 -0.02), there was no difference in functional capacity for participants with subclinical hyperthyroidism (BI 19.60 -0.09; IADL 13.51 -0.12, p > 0.05) or subclinical hypothyroidism (BI 19.82 -0.06; IADL 13.55 -0.08, p > 0.05). Over a mean 3.2-year follow-up period, there was no association between thyroid function and annual decline of either BI or IADL ( p > 0.05). No association was found between persistent subclinical thyroid dysfunction and functional capacity at baseline or during follow-up ( p > 0.05). Results were similar after excluding participants with a maximum BI and/or IADL score at baseline. Conclusion: Among well-functioning community-dwelling elderly, we found no evidence that subclinical thyroid dysfunction contributes to decreased functional capacity.

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Prevalence of Hypothyroidism in Nonalcoholic Fatty Liver Disease

et al. 2011

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Background A possible association between nonalcoholic fatty liver disease (NAFLD) and hypothyroidism has been suggested. Possible explanations for this association are the recognized links between hypothyroidism and various elements of the metabolic syndrome which is often present in NAFLD. To further explore this association, we determined the prevalence of hypothyroidism in a cohort of patients with NAFLD and analyzed the potential factors associated with hypothyroidism in this patient population. Methods Two hundred and forty six patients with biopsy proven NAFLD attending hepatology clinics at the Cleveland Clinic between October 2006 to June 2009 and 430 age, gender, race and BMI matched control subjects seen in the general internal medicine clinic were included. Patients with a clinical diagnosis of hypothyroidism who were on thyroid replacement therapy were considered to be hypothyroid. Results Hypothyroidism was more frequent among patients with NAFLD (21%vs 9.5%.; P<0.01) compared to controls and was higher in NASH patients than NAFLD patients without NASH (25% vs 12.8%, P=0.03). Subjects with hypothyroidism were 2.1 (95% CI: 1.1, 3.9,P=0.02)) and 3.8 (95% CI:2,6.9, P<0.001) times more likely to have NAFLD and NASH respectively. By Multivariate analysis, female gender (P<0.001) and increased BMI (P=.03) were associated with hypothyroidism. NAFLD subjects who reported mild alcohol consumption were less likely to have hypothyroidism compared to those who reported complete abstinence (OR 0.37, P=0.008). Conclusions A higher prevalence of hypothyroidism was demonstrated in patients with NAFLD compared to controls. Patients with hypothyroidism were more likely to have NASH. Among subjects with NALFD, female gender, increased BMI and history of abstinence from alcohol were associated with hypothyroidism. Further studies are needed in order to confirm and better characterized these findings as well as the described associations and their pathogenesis.

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Human Mitochondrial Transcription Factor A Reduction and Mitochondrial Dysfunction in Hashimoto’s Hypothyroid Myopathy

Cited by 28 publications

References 36 publications

Impact of Overt and Subclinical Hypothyroidism on Exercise Tolerance: A Systematic Review

Impact of Overt and Subclinical Hypothyroidism on Exercise Tolerance: A Systematic Review

Subclinical Thyroid Dysfunction and Functional Capacity Among Elderly

Prevalence of Hypothyroidism in Nonalcoholic Fatty Liver Disease

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