Human monocyte activation by biologic and biodegradable meshes in vitro

Orenstein, Sean B.; Qiao, Yi; Kaur, Manjot; Klueh, Ulrike; Kreutzer, D. L.; Novitsky, Yuri W.

doi:10.1007/s00464-009-0664-3

Cited by 73 publications

(37 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The orientation of the collagen fibers indicated early organization of new tissue. In another recent study the cytokine expression of human monocytes/macrophages, cultured with 3 acellular, nonecross-linked, human dermis scaffolds ( 56 This study showed a wide range of cytokine and growth factor induction associated with the different dermis materials, which may be related to the proprietary processing technologies of these products.…”

Section: Host Immune Response and Ecm Scaffold Remodelingmentioning

confidence: 93%

Extracellular matrix scaffold devices for rotator cuff repair

Derwin

Badylak

Steinmann

et al. 2010

Journal of Shoulder and Elbow Surgery

178

141

View full text Add to dashboard Cite

Section: Host Immune Response and Ecm Scaffold Remodelingmentioning

confidence: 93%

Extracellular matrix scaffold devices for rotator cuff repair

Derwin

Badylak

Steinmann

et al. 2010

Journal of Shoulder and Elbow Surgery

178

141

View full text Add to dashboard Cite

“…Orenstein et al [24] demonstrated that in vitro ADM inhibits the production of interleukin and vascular endothelial growth factor which may explain this, and in a recent case we reported the integration of Braxon ® matrix in human tissue 12 months after implantation, supporting the concept of a complete breast implant coverage made with ADM [22]. Whilst this technique may reduce capsular contracture, only observational relationships can be concluded.…”

Section: Discussionmentioning

confidence: 93%

Muscle-Sparing ADM-Assisted Breast Reconstruction Technique Using Complete Breast Implant Coverage: A Dual-Institute UK-Based Experience

Vidya

Cawthorn

2017

Breast Care

View full text Add to dashboard Cite

Background: We report our early experience of a novel muscle-sparing breast (prepectoral) reconstruction technique using a pre-shaped Braxon® mesh (acellular dermal matrix) which completely wraps around the breast implant. Methods: All patients who underwent prepectoral implant-based breast reconstruction between April 2014 and September 2015 were included in the analysis. The dermal matrix Braxon® used is a pre-shaped matrix which forms a complete implant mesh wrap. The new breast created is placed over the chest wall without disturbing the pectoralis musculature. Results: A total of 51 (42 unilateral and 9 bilateral) muscle-sparing breast reconstructions were carried out. Complications included implant loss (n = 1; 1.7%) secondary to wound infection, seroma (n = 4; 6.7%), and superficial wound dehiscence (n = 1; 1.7%) which was re-sutured without further complication. The median follow-up period was 16.4 (range 8-25) months. Conclusion: The early experience appears highly satisfactory with good clinical outcome. The novel prepectoral implant-based breast reconstruction using the mesh wrap provides an effective alternative to the more traditional submuscular implant-based technique.

show abstract

“…Once implanted, the mesh should trigger a series of events in the host that will be the key to subsequent behavior of the material, including an acute inflammatory response at the mesh/tissue interface, followed by migration of mononuclear cells to the implant site [15,18]. After penetrating the biomaterial, these cells start to secrete cytokines, proangiogenic factors, profibrogenic factors, and other signaling molecules.…”

Section: Discussionmentioning

confidence: 99%

Remodeling of Noncrosslinked Acellular Dermal Matrices in a Rabbit Model of Ventral Hernia Repair

et al. 2015

View full text Add to dashboard Cite

Background: Bioprostheses represent a significant advance in the abdominal wall reconstruction since they become degraded until their complete elimination in the recipient organism. This study examines remodeling in the host of three noncrosslinked porcine dermal collagen biomeshes: Strattice™ (St; LifeCell Corp.), XCM Biologic® Tissue Matrix (XCM; Synthes CMF) and Protexa® (Pr; Deco Med S.R.L.). Methods: Partial ventral hernia defects created in New Zealand White rabbits were repaired using the biomeshes that were placed in an inlay, preperitoneal position. At 14 and 90 days after implantation, explants were assessed in terms of their host tissue incorporation by morphological studies, collagen gene/protein expression (quantitative real-time PCR/immunofluorescence), macrophage response (immunohistochemistry) and biomechanical strength. Results: There were no cases of mortality or infection. Among our macroscopic findings, the mesh detachment detected in one third of the Pr implants at 90 days was of note. The host tissue response to all the biomeshes was similar at both time points, with a tendency observed for their encapsulation. There were no appreciable signs of mesh degradation. The extent of host tissue infiltration and collagenization was greater for St and Pr than for XCM. Macrophages were observed in zones of inflammation and tissue infiltration inside the mesh. XCM showed a greater macrophage response at 90 days (p < 0.05). Improved tensile strength was observed for St (p < 0.05) over Pr and unrepaired defects. Conclusions:St showed the best behavior, featuring good collagenization and tensile strength while also inducing a minimal foreign body reaction.

show abstract

Human monocyte activation by biologic and biodegradable meshes in vitro

Cited by 73 publications

References 40 publications

Extracellular matrix scaffold devices for rotator cuff repair

Extracellular matrix scaffold devices for rotator cuff repair

Muscle-Sparing ADM-Assisted Breast Reconstruction Technique Using Complete Breast Implant Coverage: A Dual-Institute UK-Based Experience

Remodeling of Noncrosslinked Acellular Dermal Matrices in a Rabbit Model of Ventral Hernia Repair

Contact Info

Product

Resources

About