1978
DOI: 10.1002/ijc.2910210108
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Human natural cytotoxicity in the blood and lymphoid organs of healthy donors and patients with malignant disease

Abstract: Natural cytotoxicity against CLA-4 and D6 target cells was determined in the peripheral blood of healthy donors and women with mammary carcinoma (localized to the breast and axilla), and in human normal and regional tumour lymph nodes. The NK cell activity in the blood of women with clinically localized mammary carcinoma showed a wide range of reactivities but was similar to the pattern detected in healthy controls. The NK cell activity in human normal lymph nodes also showed a wide range and was the same irre… Show more

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Cited by 67 publications
(25 citation statements)
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“…This study does not mention the hormonal status of the patients and both patient groups and male and female controls had similar cytotoxicities. Eremin et al (1978) were similarly unable to distinguish between the cytotoxic capacity of 14 breast carcinoma patients and controls mea,sured against the CLA-4 and Detroit 6 cell lines. In this study 23 untreated patients with early breast cancer showed a significant reduction in NK activity directed towards K562 target cells.…”
Section: Discussionmentioning
confidence: 89%
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“…This study does not mention the hormonal status of the patients and both patient groups and male and female controls had similar cytotoxicities. Eremin et al (1978) were similarly unable to distinguish between the cytotoxic capacity of 14 breast carcinoma patients and controls mea,sured against the CLA-4 and Detroit 6 cell lines. In this study 23 untreated patients with early breast cancer showed a significant reduction in NK activity directed towards K562 target cells.…”
Section: Discussionmentioning
confidence: 89%
“…Cunningham-Rundles et al (1981) There are several reports why our data may conflict with previously published results. The postoperative patients studied by Eremin et al (1978) and Cannon et al (1977) may have experienced a recovery of cytotoxicity after the removal of the tumour burden and the effect, of therapy may also account for the discrepancy. Further, variations in the target cells employed may influence the level of cytot,oxicity observed (Jondal et al, 1978).…”
Section: Discussionmentioning
confidence: 99%
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“…We have previously described antibodydependent cellular-cytotoxicity (ADCC) mediated by killer (K) cells, and natural cytotoxicity mediated by natural killer (NK) cells, in the peripheral blood and regional tumour-draining lymph nodes of patients with mammary carcinoma, clinically localized to the breast and axilla (Eremin et al, 1977a;1978a). In this communication we report our findings on the K and NK activity of lymphocytes isolated from the primary mammary carcinomas removed at operation from such patients.…”
mentioning
confidence: 83%
“…The role of other potential antitumour effector cells such as NK cells, K cells and macrophages needs more intensive investigation (McCredie et al, 1979;Saijo et al, 1980, The in vivo significance of NK activity and ADCC is still unclear, but these activities seems consistent with the existence of a surveillance mechanism against tumour growth (Menon & Stefani, 1978). The potential role of NK activity and ADCC in human cancer is now under extensive investigation, in spite of the inconsistent levels of NK activity and ADCC in tumour-bearing patients (Eremin et al, 1978;Forbes et al, 1981a, b (Saijo et al, 1982b). However, the kinetics of the action of anticancer agents against NK activity and ADCC are complicated.…”
Section: Diiscussionmentioning
confidence: 99%