“…Diverse workshops and meetings during the past 10 years have summarized the problems, the available assays and roadmaps for DNT in vitro assays and methods (Coecke et al, 2007; Lein et al, 2007; Crofton et al, 2011; Crofton et al, 2014; Bal-Price et al, 2015a; Bal-Price et al, 2015b). Several in vitro studies have been able to reproduce some of the relevant processes that occur in the brain such as neuronal differentiation (Hartley et al, 1999), migration (Stern et al, 2014), cell-cell interaction, neuritic development, synaptogenesis, myelinogenesis (Liu et al, 2012) and neurotransmission (Hogberg et al, 2011). In addition, they showed to be predictive of DNT (Hogberg et al, 2010; Hogberg et al, 2011; Laurenza et al, 2013; Pallocca et al, 2013).…”