Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma: possible recent trend

Mishra, Anupam; Sachadeva, Monica; Jain, Ankita; Shukla, Nimisha Mishra; Pandey, Anshuman

doi:10.1016/j.amjoto.2016.03.001

Cited by 14 publications

(7 citation statements)

References 11 publications

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“…Previous research detecting viruses within JNA have studied HPV, human herpesvirus-8 (HHV-8) and EBV: in a small sampling of 6 patients, all were positive for HPV [6], and in another study, all 15 JNA tissue samples were negative for HHV-8 and EBV [17]. Our results are the first published on B19V, HBoV1-4, BuV, TuV, CuV, and 13 HPyVs within JNA samples, showing negative findings in all patients except one, whose JNA was positive for MCPyV DNA, a known oncogenic virus found in the majority of Merkel cell carcinomas [12].…”

Section: Discussionmentioning

confidence: 99%

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Newly detected DNA viruses in juvenile nasopharyngeal angiofibroma (JNA) and oral and oropharyngeal squamous cell carcinoma (OSCC/OPSCC)

Dickinson

Silén

et al. 2018

Eur Arch Otorhinolaryngol

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Purpose Approximately 20% of cancers are estimated to have a viral etiology. We aimed to investigate whether DNA of 8 human parvoviruses [bocavirus 1–4 (HBoV1–4), parvovirus B19 (B19V), protoparvoviruses (bufa-, tusa-, and cutavirus)] and 13 human polyomaviruses (HPyV) can be detected in oropharyngeal and oral cavity squamous cell carcinoma (OPSCC/OSCC), and in juvenile nasopharyngeal angiofibroma (JNA) tissue samples. Methods Fresh samples of seven JNA tissues and ten paired tissues of OSCC/OPSCC tumor and adjacent healthy tissues were collected. DNA extraction and real-time PCRs were performed to detect HBoV1-4, B19V, bufa- tusa- and cutavirus, and HPyV genomes. Results JNA specimens were negative for all parvoviruses tested, whereas one JNA sample was Merkel cell polyomavirus (MCPyV) DNA positive. The OSCC/OPSCC samples were negative for the human protoparvoviruses, HBoV1-4, and all human polyomaviruses, except for one patient that was MCPyV DNA positive in both healthy and tumor tissues. Seven OSCC/OPSCC patients were positive for B19V DNA, three of them in both healthy and cancerous tissues and three in only healthy tissues. Three of the B19V DNA-positive patients harbored viral genotype 1, three genotype 2, and one genotype 3B. Conclusions These are the first reports of MCPyV and B19V DNA being detected in JNA and OPSCC. The significance of viral DNA positivity is unclear. B19V DNA is known to remain in the tissues lifelong, however, it is of interest that there are some patients with B19 DNA in healthy tissue, but not in the corresponding cancer tissue.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, it seemed relevant to investigate a viral etiology for JNA. Furthermore, HPV has been discovered in all samples in a small JNA cohort [6].…”

Section: Introductionmentioning

confidence: 99%

Newly detected DNA viruses in juvenile nasopharyngeal angiofibroma (JNA) and oral and oropharyngeal squamous cell carcinoma (OSCC/OPSCC)

Dickinson

Silén

et al. 2018

Eur Arch Otorhinolaryngol

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“…A possible role for human herpes simplex virus‐8 (HSV‐8), Epstein–Barr virus (EBV), and human papillomavirus (HPV) has also been considered . Although juvenile angiofibroma does not seem to be associated with HSV‐8 or EBV, there is evidence of HPV infection at DNA and protein levels . HPV is also likely to increase the cell proliferation rate in juvenile angiofibroma and may be a possible etiologic or aggravating factor effecting early presentation/recurrent disease and accounting for variability in clinical behavior, respectively.…”

Section: Introductionmentioning

confidence: 99%

Nasal juvenile angiofibroma: Current perspectives with emphasis on management

et al. 2017

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Juvenile angiofibroma is an uncommon, benign, locally aggressive vascular tumor. It is found almost exclusively in young men. Common presenting symptoms include nasal obstruction and epistaxis. More advanced tumors may present with facial swelling and visual or neurological disturbances. The evaluation of patients with juvenile angiofibroma relies on diagnostic imaging. Preoperative biopsy is not recommended. The mainstay of treatment is resection combined with preoperative embolization. Endoscopic surgery is the approach of choice in early stages, whereas, in advanced stages, open or endoscopic approaches are feasible in expert hands. Postoperative radiotherapy (RT) or stereotactic radiosurgery seem valuable in long-term control of juvenile angiofibroma, particularly those that extend to anatomically critical areas unsuitable for complete resection. Chemotherapy and hormone therapy are ineffective. The purpose of the present review was to update current aspects of knowledge related to this rare and challenging disease. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1033-1045, 2017.

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“…In recent years, theories have appeared suggesting a relationship between the human papillomavirus and juvenile angiofibroma. In the conducted studies it was noticed that HPV can increase the rate of tumor cell proliferation and even be an etiological factor of JNA [14]. There is a vascular theory that explains the period, location and structure of the tumor.…”

Section: Description Of the State Of Knowledge Etiologymentioning

confidence: 99%

Juvenile angiofibroma: etiology, diagnosis, treatment

Madalena

Blicharz

Drozd

et al. 2020

J Educ Health Sport

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the tumor, depending on its location. Due to the vascularnature of the tumor, the basic preoperative procedure is tumor vessel embolization, which allows reducing blood loss during surgery. Conclusions: Juvenile angiofibroma shows some characteristic features-it occurs at a similar age, in one sex and in one localization in the organism. Due to the invasive tumor growth, the risk of bone destruction and relapse, the role of imaging tests is important, allowing the diagnosis of a tumor at an early stage of its development.

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Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma: possible recent trend

Cited by 14 publications

References 11 publications

Newly detected DNA viruses in juvenile nasopharyngeal angiofibroma (JNA) and oral and oropharyngeal squamous cell carcinoma (OSCC/OPSCC)

Newly detected DNA viruses in juvenile nasopharyngeal angiofibroma (JNA) and oral and oropharyngeal squamous cell carcinoma (OSCC/OPSCC)

Nasal juvenile angiofibroma: Current perspectives with emphasis on management

Juvenile angiofibroma: etiology, diagnosis, treatment

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