Human Papillomavirus-16 Associated Adenocarcinoma NOS of Base of Tongue

Perez-Ordoñez, Bayardo; Irish, Jonathan C.; Yu, Eugene; Gillison, Maura L.

doi:10.1007/s12105-012-0404-1

Cited by 20 publications

(8 citation statements)

References 32 publications

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“…It is our hope and expectation that the description of this entity herein will lead to recognition of similar cases by others. Indeed, while this study was in preparation, Perez-Ordoñez and colleagues [12] reported a single patient with an HPV-associated adenocarcinoma of the base of the tongue, with comparable histologic and immunophenotypic features, although long-term follow-up was not available. We would propose that for adenocarcinomas arising in the oropharynx, or for metastatic adenocarcinomas of unknown primary in neck lymph nodes showing a prominent cystic component, the consideration of an HPV association may be particularly appropriate.…”

Section: Discussionmentioning

confidence: 98%

Human papillomavirus–associated adenocarcinoma of the base of the tongue

et al. 2013

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Section: Discussionmentioning

confidence: 98%

Human papillomavirus–associated adenocarcinoma of the base of the tongue

et al. 2013

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“…We present an additional case of HPV-associated adenocarcinoma, NOS, of the BOT, along with the updated clinical history and molecular testing of the three previously reported cases [9,10]. As in prior reports, this adenocarcinoma showed no morphologic or immunophenotypic features of a named salivary type carcinoma.…”

Section: Discussionmentioning

confidence: 53%

“…HPV-associated oropharyngeal SCC treated from 1983 to 2013 at the University of Pittsburgh Medical Center and identified as part of a prior project (n = 89) [20] were re-reviewed with the knowledge of HPV-associated adenocarcinoma, NOS, of the BOT [9,10].…”

Section: Methodsmentioning

confidence: 99%

“…Cases [9,10] Tissue cores from tumor targets were obtained as previously described [23] or microdissected from unstained slides under …”

Section: Pik3ca Mutation Analysis Of the Previously Reportedmentioning

confidence: 99%

“…In addition to the non-keratinizing morphology most commonly seen in oropharyngeal SCC, other variants of SCC, including papillary and lymphoepithelial, have been recognized [3,4]. Recently, the spectrum of HPV-associated oropharyngeal carcinomas was significantly expanded to include a subset of adenosquamous carcinomas [5], neuroendocrine carcinomas [6,7], un-differentiated carcinomas [8] and adenocarcinomas of the base of the tongue (BOT) [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Human Papillomavirus-Associated Adenocarcinoma of the Base of Tongue: Potentially Actionable Genetic Changes

Chang

Nikiforova

Johnson

et al. 2013

Head and Neck Pathol

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While human papillomavirus (HPV)-positive squamous and adenosquamous carcinomas of the oropharynx have been well characterized, HPV-associated pure adenocarcinomas are exceptionally rare. Herein we report the clinicopathologic features of one such HPV-associated adenocarcinoma of the base of tongue (BOT). A 70 year-old male presented with a 2.8 cm base of tongue mass and lymphadenopathy. Immunohistochemically, the adenocarcinoma was p63 negative and p16 positive. HPV positivity was shown by in situ hybridization. Features of salivary type tumor or metastasis from a distant primary were absent. IonTorrent TM semiconductor sequencing analysis for 739 cancer-associated mutations in 46 actionable cancer genes was performed and PIK3CA exon 9 (p.E545K) and MET exon 2 (p.E168D) mutations were identified. No PIK3CA or MET amplification was identified by fluorescence in situ hybridization. A re-review of archival HPV-positive oropharyngeal squamous cell carcinomas (n = 89, 1983-2013) showed no additional cases of adenocarcinoma. The clinical follow-up for the three previously reported cases of HPVassociated adenocarcinoma of the BOT was updated. All previously reported cases were tested and were negative for PIK3CA exon 9 and 20 and MET exon 2 mutations. These findings offer a molecular basis for potential therapeutic use of PIK3CA inhibitors in a subset of patients with HPVassociated adenocarcinoma of BOT.

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HPV‐associated neuroendocrine carcinomas of the head and neck in FNA biopsies: Clinicopathologic features of a rare entity

Krane

Pantanowitz

2018

Cancer Cytopathology

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Background The majority of human papillomavirus (HPV)–associated oropharyngeal carcinomas are squamous cell carcinomas; however, there are rare reports of HPV–associated neuroendocrine carcinomas (HPV‐NECs) in the upper aerodigestive tract. The aim of this study was to characterize the diagnostic features of fine‐needle aspiration (FNA) cases of head and neck HPV‐NEC. Methods Cytology cases of HPV‐NEC were identified over a 3‐year period from 2 institutions. Clinical, cytomorphologic, and ancillary test results were evaluated. Results Five FNA cases of HPV‐NEC were identified from 4 patients with cervical lymph node metastases with primaries in the oropharynx (n = 2), nasopharynx (n = 1), and larynx (n = 1). Three cases showed mixed small cell and large cell neuroendocrine morphologies; 1 case was a small cell carcinoma, and the last case appeared as a large cell neuroendocrine carcinoma. All tumors were strongly positive for synaptophysin and p16 and negative for p63/p40. Two cases tested for INSM1 showed diffuse nuclear staining. HPV was confirmed by in situ hybridization in 4 cases, and HPV‐18 was detected by polymerase chain reaction in the fifth case. Retinoblastoma (Rb) staining was moderate to weak (5/5), and p53 was weakly positive (5/5). Conclusions Head and neck HPV‐NEC is a rare, aggressive entity that can show mixed small and large cell features and p16 upregulation; p53 and Rb are variable with limited diagnostic utility. Because p16 positivity can be nonspecific, confirmatory HPV testing is required and may be helpful in determining the primary site for neuroendocrine carcinoma of an unknown primary. The accurate diagnosis of HPV‐NEC is also important because of its worse prognosis in comparison with HPV‐associated squamous cell carcinoma.

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Human Papillomavirus-16 Associated Adenocarcinoma NOS of Base of Tongue

Cited by 20 publications

References 32 publications

Human papillomavirus–associated adenocarcinoma of the base of the tongue

Human papillomavirus–associated adenocarcinoma of the base of the tongue

Human Papillomavirus-Associated Adenocarcinoma of the Base of Tongue: Potentially Actionable Genetic Changes

HPV‐associated neuroendocrine carcinomas of the head and neck in FNA biopsies: Clinicopathologic features of a rare entity

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