Human papillomavirus 16 or 18 infection and prostate cancer risk: a meta-analysis

Lin, Yiwei; Mao, Qinan; Zheng, Xiangyi; Yang, Kai; Chen, H.; Zhou, Chenhe; Xie, Liping

doi:10.1007/s11845-011-0692-6

Cited by 45 publications

(51 citation statements)

References 45 publications

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“…HPV16 and 18 were most frequent HPV types in all cancers ranging from 50% to 84.7%. These findings are consistent to some epidemiological studies that had been reported HPV detection in variety of cancers (Syrjanen, 2002a;2002b;Iftner et al, 2003;Rezazadeh et al, 2009a;Tornesello et al, 2009;Li et al, 2011;Lin et al, 2011;Munoz et al, 2012;Simoes et al, 2012). However, detection of HPV DNA in these cancers by PCR alone is inadequate to verify causality.…”

Section: Discussionsupporting

confidence: 90%

“…In addition, a number of non-malignant diseases such as genital warts and recurrent respiratory papillomatosis are attributable to HPV, particularly HPV6 and 11 (Chelimo et al, 2013;Gillison et al, 2012c). Moreover, HPV detected in several other cancers including esophageal squamous cell carcinoma (Syrjanen, 2002b;Tornesello et al, 2009), lung 1 * (Rezazadeh et al, 2009b;Munoz et al, 2012), prostate (Lin et al, 2011), ovarian (Rosa et al, 2013), breast (Simoes et al, 2012), skin (Iftner et al, 2003), colorectal (Burnett-Hartman et al, 2008;Lorenzon et al, 2011) and urinary tract cancers (Li et al, 2011), but association of HPV to these cancers is controversial.…”

Section: Introductionmentioning

confidence: 99%

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Human Papillomavirus Burden in Different Cancers in Iran: a Systematic Assessment

Jalilvand¹,

Shoja²,

Hamkar³

2014

Asian Pacific Journal of Cancer Prevention

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Certain types of human papillomaviruses (HPVs) are undoubtedly involved in genesis of human malignancies. HPV plays an etiological role in cervical cancer, but also in many vaginal, vulvar, anal and penile cancers, as well as head and neck cancers. In addition, a number of non-malignant diseases such as genital warts and recurrent respiratory papillomatosis are attributable to HPV. Moreover, HPV forms have detected in several other cancers including esophageal squamous cell carcinoma, lung, prostate, ovarian, breast, skin, colorectal and urinary tract cancers, but associations with etiology in these cases is controversial. The aim of this systematic assessment was to estimate the prevalence of HPV infection and HPV types in HPV-associated cancers, HPV-related non-malignant diseases and in cancers that may be associated with HPV in Iran. The present investiagtion covered 61 studies on a variety of cancers in Iranian populations. HPV prevalence was 77.5 % and 32.4% in cervical cancer and head and neck cancers, respectively. HPV was detected in 23.1%, 22.2%, 10.4%, 30.9%, 14% and 25.2% of esophageal squamous cell, lung, prostate, urinary tract cancers, breast and skin cancers, respectively. HPV16 and 18 were the most frequent HPV types in all cancers. The findings of present study imply that current HPV vaccines for cervical cancer may decrease the burden of other cancers if they are really related to HPV.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Burden in Different Cancers in Iran: a Systematic Assessment

Jalilvand¹,

Shoja²,

Hamkar³

2014

Asian Pacific Journal of Cancer Prevention

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“…Overall, HPV may serve various roles in the development of cervical and PCa, and further high quality studies are required. In a meta-analysis study published in 2011, Lin et al (75) concluded that the causal role of HPV in prostate cancer remained doubtful, as the pooled results of DNA detection method and serologic assays (antibody) were negative; however, no statistical significance was observed in serological assays. The result was positive when the analysis was limited to HPV detection of type 16 infection in PCa tissues (75).…”

Section: Discussionmentioning

confidence: 99%

“…In a meta-analysis study published in 2011, Lin et al (75) concluded that the causal role of HPV in prostate cancer remained doubtful, as the pooled results of DNA detection method and serologic assays (antibody) were negative; however, no statistical significance was observed in serological assays. The result was positive when the analysis was limited to HPV detection of type 16 infection in PCa tissues (75). Serological testing has the following limitations: i) Antibody cross-reactivity; ii) it is difficult to establish a temporal association between infection and cancer; iii) numerous individuals could be infected by HPV throughout their lifetime, so the control group may be positive; iv) based on a number of etiological studies, it is commonly agreed that HPV does not induce a generalized viremia; and v) only persistent infections induce pathological alterations and serological detection indicates HPV exposure rather than the exact site of infection (76).…”

Section: Discussionmentioning

confidence: 99%

Association between human papillomavirus and prostate cancer: A meta-analysis

et al. 2017

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Abstract. Observational studies have suggested an association between human papillomavirus (HPV) infection and the risk of prostate cancer (PCa). However, the association between HPV infection and the risk of PCa remains unclear. The aim of the present meta-analysis study was to investigate whether HPV serves a role in increasing the risk of PCa. Relevant previous studies up to May 2015 were searched in PubMed, Web of Science, Cochrane library, Chinese National Knowledge Infrastructure, China Wan Fang database and China Biomedical Literature Database. A random-effects model or fixed-effects model was employed to determine odds ratios (ORs) with 95% confidence intervals (CIs), when appropriate. Heterogeneity was evaluated using Q and I 2 statistical analysis. A total of 24 case-control studies involving 971 patients and 1,085 controls were investigated to estimate the association between HPV infection and PCa risk. The pooled estimate for OR was 2.27 (95% CI, 1.40-3.69). Stratified pooled analyses were subsequently performed according to the HPV detection methods, geographical regions, publication years and types of tissue. Sensitivity analysis based on various exclusion criteria maintained the significance with respect to PCa individually. Little evidence of publication bias was observed. The meta-analysis suggested that HPV infection is associated with increasing risk of PCa, which indicated a potential pathogenetic link between HPV and PCa.

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“…The association between HPV and cancer of the prostate is discussed e.g. by Dodd et al [1993], Martinez-Fierro et al [2010] as well as by Lin et al [2011].…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infection and Human Cancer

Rubinstein¹,

Järveläinen²

2012

JVM

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The article is a review and the aim is to discuss human papillomavirus (HPV)-associated human cancers. In the text, the concept of Harald zur Hausen plays an essential role.Cervical, vulval, vaginal, penile, anal, orophrayngeal and conjunctival cancers are important neoplasias induced by HPVs. HPVs count annually worldwide for about 28% of the cancer incidence attributable to infections. HPV self-testing is an essential new method of HPV detection -it is gaining increasing importance. Another vital move is HPV vaccination.

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Human papillomavirus 16 or 18 infection and prostate cancer risk: a meta-analysis

Cited by 45 publications

References 45 publications

Human Papillomavirus Burden in Different Cancers in Iran: a Systematic Assessment

Human Papillomavirus Burden in Different Cancers in Iran: a Systematic Assessment

Association between human papillomavirus and prostate cancer: A meta-analysis

Human Papillomavirus Infection and Human Cancer

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