Human Papillomavirus and Overall Survival After Progression of Oropharyngeal Squamous Cell Carcinoma

Fakhry, Carole; Zhang, Qiang; Nguyen-Tân, Phuc Félix; Rosenthal, David I.; El‐Naggar, Adel K.; Garden, Adam S.; Soulières, Denis; Trotti, Andy; Avizonis, Vilija N.; Ridge, John A.; Harris, Jonathan; Le, Quynh Thu; Gillison, Maura L.

doi:10.1200/jco.2014.55.1937

Cited by 473 publications

(476 citation statements)

References 28 publications

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“…Analyses from clinical trials indicate that patients with locally advanced HPV-positive H&N cancers experience improved response to treatment and overall survival (OS) and progression-free survival (PFS) when compared with HPV-negative tumors, [30][31][32][33][34] with one analysis showing that p16-positive nonoropharyngeal squamous H&N cancers have a better prognosis compared with p16-negative nonoropharyngeal cancers. 35 Treatment response is improved in patients receiving both chemoradiation 30,31 and conventional RT.…”

Section: Hpv and Treatment Of Oropharyngeal Cancermentioning

confidence: 99%

NCCN Guidelines Insights: Head and Neck Cancers, Version 2.2017

Adelstein¹,

Gillison²,

Pfister³

et al. 2017

J Natl Compr Canc Netw

283

241

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The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the head and neck (H&N), and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding the increase in human papillomavirus-associated oropharyngeal cancer and the availability of immunotherapy agents for treatment of patients with recurrent or metastatic H&N cancer.

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Section: Hpv and Treatment Of Oropharyngeal Cancermentioning

confidence: 99%

NCCN Guidelines Insights: Head and Neck Cancers, Version 2.2017

Adelstein¹,

Gillison²,

Pfister³

et al. 2017

J Natl Compr Canc Netw

283

241

View full text Add to dashboard Cite

show abstract

“…Tobacco and alcohol are common risk factors for this group of cancer. Although the role of human papilloma virus (HPV) is clearly understood in the prognosis of oropharyngeal tumors (6), the role of HPV as an etiologic agent and/or a prognostic marker in oral tongue squamous cell carcinoma (OTSCC) is not yet established.…”

Section: Introductionmentioning

confidence: 99%

A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes

Krishnan

Dhas

Nair

et al. 2016

Molecular Cancer Research

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Oral tongue squamous cell carcinomas (OTSCC) are a homogenous group of aggressive tumors in the head and neck region that spread early to lymph nodes and have a higher incidence of regional failure. In addition, there is a rising incidence of oral tongue cancer in younger populations. Studies on functional DNA methylation changes linked with altered gene expression are critical for understanding the mechanisms underlying tumor development and metastasis. Such studies also provide important insight into biomarkers linked with viral infection, tumor metastasis, and patient survival in OTSCC. Therefore, we performed genome-wide methylation analysis of tumors (N ¼ 52) and correlated altered methylation with differential gene expression. The minimal tumor-specific DNA 5-methylcytosine signature identified genes near 16 different differentially methylated regions, which were validated using genomic data from The Cancer Genome Atlas cohort. In our cohort, hypermethylation of MIR10B was significantly associated with the differential expression of its target genes NR4A3 and BCL2L11 (P ¼ 0.0125 and P ¼ 0.014, respectively), which was inversely correlated with disease-free survival (P ¼ 9EÀ15 and P ¼ 2EÀ15, respectively) in patients. Finally, differential methylation in FUT3, TRIM5, TSPAN7, MAP3K8, RPS6KA2, SLC9A9, and NPAS3 genes was found to be predictive of certain clinical and epidemiologic parameters.Implications: This study reveals a functional minimal methylation profile in oral tongue tumors with associated risk habits, clinical, and epidemiologic outcomes. In addition, NR4A3 downregulation and correlation with patient survival suggests a potential target for therapeutic intervention in oral tongue tumors. Data from the current study are deposited in the NCBI Geo database (accession number GSE75540).

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“…Easily acquired hematologic profiles might be used to select patients at higher risk for locoregional recurrence of distant failure for therapeutic intensification by induction chemotherapy. Alternatively, those with excellent survival probability might be selected for careful and judicious therapeutic de-escalation by use of definitive radiotherapy alone 7,23 , especially when current AJCC staging provides limited guidance regarding risk-assessment for OPC 5,6,21,38 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Pretherapy Platelet Elevation in Oropharyngeal Cancer Patients Treated With Chemoradiation

Shoultz-Henley

Garden

Mohamed

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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Human Papillomavirus and Overall Survival After Progression of Oropharyngeal Squamous Cell Carcinoma

Abstract: Tumor HPV status is a strong and independent predictor of OS after disease progression and should be a stratification factor for clinical trials for patients with recurrent or metastatic OPC.

Cited by 473 publications

References 28 publications

NCCN Guidelines Insights: Head and Neck Cancers, Version 2.2017

NCCN Guidelines Insights: Head and Neck Cancers, Version 2.2017

A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes

Prognostic Value of Pretherapy Platelet Elevation in Oropharyngeal Cancer Patients Treated With Chemoradiation

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