Human papillomavirus and predictors of cervical intraepithelial neoplasia among young mothers in a prospective follow-up study

Louvanto, Karolina; Syrjänen, Kari; Rintala, Marjut; Grénman, Seija; Syrjänen, Stina

doi:10.1111/j.1600-0412.2010.01029.x

Cited by 9 publications

(9 citation statements)

References 28 publications

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“…293-297), something we have repeatedly published on in past years (2,3,4). We also find the halving of perinatal mortality (mainly from stillbirths) in placental abruption shown in a large epidemiological study from Finland (Minna Tikkanen and coworkers, Helsinki and Tampere) of real interest.…”

supporting

confidence: 56%

“…Most of those having bariatric surgery are women, often of reproductive age and therefore their situation merits specific attention in our overindulgent and overweight era.Enrique Coppolillo and co-workers in Buenos Aires, Argentina, do again point to the need for careful followup of women who present with cytologic changes of a substatial nature in pregnancy (pp. 293-297), something we have repeatedly published on in past years (2,3,4). We also find the halving of perinatal mortality (mainly from stillbirths) in placental abruption shown in a large epidemiological study from Finland (Minna Tikkanen and coworkers, Helsinki and Tampere) of real interest.…”

supporting

confidence: 56%

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Assessing, teaching and defining: issues in obstetrics and gynecology

Nisell¹,

Geirsson²

2013

Acta Obstet Gynecol Scand

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The March issue contents are varied and of good quality. There is a meta-analysis from Louise Baandrup and colleagues in Copenhagen, on the commonly used NSAID drugs and ovarian cancer risks. Research at the Danish Cancer Society has a world-wide reputation and can be considered as authoritative when it comes to both their own epidemiological data-evaluation and reasoned opinions done in a scientifically good fashion. Even if not conclusive, the study is helpful for showing where emphasis must be placed for adding to current knowledge in one of the more difficult fields of our speciality; ovarian cancer management. The discussion is clear on what problems must be overcome when common over-the-counter drugs need to be evaluated in relation to well defined disease entities.Cesarean section is one of the first operations that a trainee in this speciality has to learn and indeed wants to learn fast for the glory of it. Most of us have historically acquired our skills initially on a teacher-apprentice basis where personal preferences of the senior may have weighed more than securely based evidence. Even the now "fashionable" guidelines may differ on what one is recommended to do. Kristine Madsen and colleagues in Copenhagen and Hiller€ od, Denmark, discuss the training for cesarean section on pp. 256-263. When they suggest international training programs in the last part of their discussion, then such educational strategies are an obvious task to address within our inter-Nordic collaboration efforts. We, the authors of this months Editors Message, know of course exactly how a cesarean section should be done, from start to finish, but who is to say that our individual and probably not quite uniform methods are each the best? One thing is certain: it should not be us. Operative procedures evolve and need scientific scrutiny, not least the common ones. That also applies to bariatric surgery, which Mette Kjaer and Lisbeth Nilas, also from Copenhagen, consider in relation to pregnancy on pp. 264-271. That a post-procedure pregnancy can be fatal was recently shown in this journal (1). So far much of the evidence presented on bariatric surgery and pregnancy is in the form of small case series, but in this prospective data-gathering is essential. Most of those having bariatric surgery are women, often of reproductive age and therefore their situation merits specific attention in our overindulgent and overweight era.Enrique Coppolillo and co-workers in Buenos Aires, Argentina, do again point to the need for careful followup of women who present with cytologic changes of a substatial nature in pregnancy (pp. 293-297), something we have repeatedly published on in past years (2,3,4). We also find the halving of perinatal mortality (mainly from stillbirths) in placental abruption shown in a large epidemiological study from Finland (Minna Tikkanen and coworkers, Helsinki and Tampere) of real interest. This shows what still can be achieved in part through changing population characteristics (decrease in smoking) and service provis...

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supporting

confidence: 56%

supporting

confidence: 56%

Assessing, teaching and defining: issues in obstetrics and gynecology

Nisell¹,

Geirsson²

2013

Acta Obstet Gynecol Scand

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“…In this cohort, six different outcomes have been identified for cervical HPV infections: (i) always negative, (ii) incident HPV infection (women who were HPV-negative at baseline and acquired new HPV infection during the FU), (iii) type-specific persistence, (iv) non-type-specific persistence, (v) fluctuation (intermittently HPV+ and HPV−), and (vi) clearance (transient) (Louvanto et al , 2010a, b, 2011).…”

Section: Resultsmentioning

confidence: 99%

Lack of type-specific concordance between human papillomavirus (HPV) serology and HPV DNA detection in the uterine cervix and oral mucosa

Paaso

Louvanto

Syrjänen

et al. 2011

Journal of General Virology

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There is limited knowledge about longitudinal genotype-specific concordance between human papillomavirus (HPV) serology and co-existent presence of HPV DNA in the uterine cervix. The role of oral HPV infections in inducing serological response is unclear, as is the effect of HPV antibodies on the outcome of oral HPV infections. The present study is part of the Finnish Family HPV Study designed to evaluate dynamics of HPV infections within families. Here, we correlated the point prevalence of HPV6, 11, 16, 18 and 45 antibodies and concomitant genotype-specific HPV DNA detection in cervical and oral samples of 323 mothers during their 3 year (mean 37.5 months) follow-up. The mean age of these pregnant mothers at enrolment (third trimester) was 25.5 years. HPV antibodies were analysed with multiplex HPV serology and HPV genotyping was performed using a Multimetrix kit (Progen Biotechnik). There was no concordance between cervical DNA detection and co-existent seropositivity, and the same was true even in samples taken 12 months apart. Women who cleared their cervical HPV16 infection had the highest HPV16 antibody levels, whereas those who acquired incident HPV16 infections had the lowest antibody levels. Neither the presence nor the dynamics of oral HPV DNA had any correlation with HPV serology.

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“…Up to 90% HPV infections are eliminated after 12–24 months [2-5]. Only 10-15% of women develop a persistent infection, which is one of the most important risk factors for cervical carcinogenesis [6-9]. Even short-time HPV persistence has been associated with higher risk for cervical intra-epithelial neoplasia, compared to women without a history of HPV infection [10,11].…”

Section: Introductionmentioning

confidence: 99%

HPV clearance in postpartum period of HIV-positive and negative women: a prospective follow-up study

et al. 2013

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BackgroundHPV persistence is a key determinant of cervical carcinogenesis. The influence of postpartum on HPV clearance has been debated. This study aimed to assess HPV clearance in later pregnancy and postpartum among HIV-positive and negative women.MethodsWe conducted a follow-up study with 151 HPV-positive women coinfected with HIV, in 2007–2010. After baseline assessment, all women were retested for HPV infection using PCR in later pregnancy and after delivery. Multivariable logistic regressions assessed the putative association of covariates with HPV status in between each one of the successive visits.ResultsSeventy-one women (47%) have eliminated HPV between the baseline visit and their second or third visits. HIV-positive women took a significantly longer time (7.0 ± 3.8 months) to clear HPV, compared to those not infected by HIV (5.9 ± 3.0 months). HPV clearance was significantly more likely to take place after delivery than during pregnancy (84.5% x 15.5%).ConclusionsBoth HIV-positive and negative women presented a significant reduction in HPV infection during the postpartum period. HIV-positive status was found to be associated with a longer period of time to clear HPV infection in pregnant women.

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Human papillomavirus and predictors of cervical intraepithelial neoplasia among young mothers in a prospective follow-up study

Cited by 9 publications

References 28 publications

Assessing, teaching and defining: issues in obstetrics and gynecology

Assessing, teaching and defining: issues in obstetrics and gynecology

Lack of type-specific concordance between human papillomavirus (HPV) serology and HPV DNA detection in the uterine cervix and oral mucosa

HPV clearance in postpartum period of HIV-positive and negative women: a prospective follow-up study

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