Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study

Jørgensen, Kit Riegels; Høyer, Søren; Jakobsen, John; Jensen, Thor; Marcussen, Niels; Lam, Gitte Wrist; Hasselager, Thomas; Thind, Peter; Toft, Birgitte Grønkær; Steiniche, Torben; Jensen, Jørgen Bjerggaard

doi:10.1080/21681805.2018.1531920

Cited by 12 publications

(8 citation statements)

References 19 publications

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“…Studies on larger number of SCC patients have either focused on specific schistosomal infection 4 or human papillomavirus. 32 With our findings that common UTIs specifically increases the risk of SCC, but show limited association to urothelial carcinomas, our study thus emphasizes the importance of distinguishing between histological types when examining risk of bladder cancer. 33 In interpreting our finding of a slight association for urothelial carcinoma with UTI-specific antibiotics it should be acknowledged that even a small relative increase in risk of urothelial carcinoma would translate to a higher absolute risk than that observed for SCC, due to the higher incidence of urothelial cancer.…”

Section: Discussionsupporting

confidence: 65%

Urinary tract infections and risk of squamous cell carcinoma bladder cancer: A Danish nationwide case–control study

Pottegård

Kristensen

Friis

et al. 2020

Intl Journal of Cancer

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Schistosoma haematobium infection can lead to squamous cell carcinomas (SCC) of the bladder. Whether this also applies to more common urinary tract infections (UTIs) is unclear. We therefore aimed to investigate the association between UTIs, reflected by the use of specific antibiotics and risk of SCC of the bladder. We conducted a Danish nationwide case-control study and identified histologically verified bladder cancer cases (2000-2015; n = 12,271) and age-and sex-matched cancerfree controls. We computed odds ratios (ORs) with 95% confidence intervals (CI) associating the use of UTI-specific antibiotics with SCC bladder cancer, using conditional logistic regression. We applied a 2-year lag-time to minimize reverse causation. To aid interpretation, similar analyses were performed for other bladder cancer types and other antibiotics. We identified 333 SCC cases (2.7% of all bladder cancers). Compared to no use (0-1 prescription), high-use (≥10 prescriptions) of UTI-specific antibiotics was associated with SCC with an OR of 11.4 (CI 7.6-17.2) and a clear dose-response pattern (p trend < 0.001). Use of phenoxymethylpenicillin, an antibiotic not used against UTIs, was not associated with SCC after adjustment for use of UTIspecific antibiotics (OR 0.5). Furthermore, UTI-specific antibiotic use was not associated with urothelial carcinomas (n = 11,029; OR 1.13; CI 0.97-1.32). Excluding patients with known urogenital disease did not influence the SCC estimates (overall OR 10.8; CI 6.2-18.9). Data on smoking were lacking, however, a quantitative bias analysis suggested this to be of limited importance. In conclusion, common UTIs are strong, dose-dependent and specifically associated with risk of SCC of the bladder.Additional Supporting Information may be found in the online version of this article.

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Section: Discussionsupporting

confidence: 65%

Urinary tract infections and risk of squamous cell carcinoma bladder cancer: A Danish nationwide case–control study

Pottegård

Kristensen

Friis

et al. 2020

Intl Journal of Cancer

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“…Jørgensen и соавт. провели работу, в которой оценивали связь между ВПЧ, онкопротеином p16INK4a и плоскоклеточным РМП [35]. Пациенты были разделены на три группы на основании гистологического диагноза.…”

Section: роль впч-инфекции в канцерогенезе мочевого пузыряunclassified

“…Однако сопутствующий ВПЧ и повышенный показатель p16INK4a были обнаружены только у 4/100 (4%) пациентов. В результате исследования продемонстрировано наличие ВПЧ у пятой части пациентов с плоскоклеточным РМП, что может иметь значительную роль в канцерогенезе плоскоклеточного РМП [35].…”

Section: роль впч-инфекции в канцерогенезе мочевого пузыряunclassified

The role of herpes and human papillomavirus infection in prostate and bladder carcinogenesis

Mikhaleva

Камалов

Maryin³

et al. 2022

Bûll. sib. med.

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Human papillomavirus (HPV) is a small epithelial, non-enveloped, double-stranded DNA virus that belongs to the Papillomaviridae family. HPV infection is one of the most common sexually transmitted infections, and certain types of HPV are known to be carcinogenic to humans. According to the scientific literature, there is reliable information about the role of highly oncogenic HPV types in the development of cervical, anal, vulvar, vaginal, penile, and oropharyngeal cancer.Currently, a relevant and promising research area is the study of the role of HPV infection in prostate cancer (PC) and bladder cancer (BC), but scientific data on the potential pathogenetic relationship between these phenomena remain contradictory. An in-depth study of the question how herpes and human papillomavirus affect the origin of malignant tumors of the prostate and bladder, as well as the course of these diseases, and the prognosis of their development can become a source of information for development of new approaches to their diagnosis, prevention, and monitoring of morbidity. This literature review analyzes the results of modern studies on the role of oncogenic HPV types in the carcinogenesis of PC and BC.

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“…The HPV DNA PCR methods and immunohistochemical staining of p16INK4a used by our laboratory have previously been reported in detail 3 …”

Section: All Patients Hpv‐positive Patients Hpv‐negative Patients Pmentioning

confidence: 99%

Human papilloma virus prevalence in penile cancer: A multicenter study from Denmark (DaPeCa‐6)

et al. 2020

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Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study

Cited by 12 publications

References 19 publications

Urinary tract infections and risk of squamous cell carcinoma bladder cancer: A Danish nationwide case–control study

Urinary tract infections and risk of squamous cell carcinoma bladder cancer: A Danish nationwide case–control study

The role of herpes and human papillomavirus infection in prostate and bladder carcinogenesis

Human papilloma virus prevalence in penile cancer: A multicenter study from Denmark (DaPeCa‐6)

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